Compositions including and methods of using conformationally restricted angiotensin II antagonist

ABSTRACT

Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders.

This is a continuation-in-part of U.S. application Ser. No. 08/127,147 filed on Sep. 24, 1993 now U.S. Pat. No. 5,426,105.

FIELD OF THE INVENTION

Conformationally restricted non-peptide angiotensin II (AII) antagonists are described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Of particular interest are heteroatom-containing fused bicyclic compounds having a substituted biphenyl moiety attached thereto.

BACKGROUND OF THE INVENTION

Angiotensin II is the primary hormone active in the renin-angiotensin system and elicits effects on the regulation of arterial pressure, volume homeostasis and hypertension. Activation of the renin-angiotensin cascade begins with renin secretion from the juxtaglomerular apparatus of the kidney and culminates in the formation of angiotensin II, the primary active species of this system. Angiotensin II is an octapeptide which is a potent vasoconstrictor and also promotes aldosterone secretion, promotes sodium and fluid retention, inhibits renin secretion and increases vasopressin secretion.

Previous studies have shown that antagonizing angiotensin II at the receptor level is a viable approach to controlling the renin-angiotensin system. There are several known angiotensin II antagonists, many of which are peptidic in nature. Such peptidic compounds are of limited use due to their lack of oral bioavailability or their short duration of action. Also, commercially-available peptidic angiotensin II antagonists (e.g., Saralasin) have a significant residual agonist activity which further limits their therapeutic application.

Non-peptidic compounds with angiotensin II antagonist properties are known. For example, the sodium salt of 2-n-butyl-4-chloro-1-(2-chlorobenzyl)imidazole-5-acetic acid has specific competitive angiotensin II antagonist activity as shown in a series of binding experiments, functional assays and in vivo tests P. C. Wong et al, J. Pharmacol. Exp. Ther., 247(1), 1-7 (1988)!. Also, the sodium salt of 2-butyl-4-chloro-1-(2-nitrobenzyl)imidazole-5-acetic acid has specific competitive angiotensin II antagonist activity as shown in a series of binding experiments, functional assays and in vivo tests A. T. Chiu et al, European J. Pharmacol., 157, 13-21 (1988)!. A family of 1-benzylimidazole-5-acetate derivatives has been shown to have competitive angiotensin II antagonist properties A. T. Chiu et al, J. Pharmacol. Exp. Ther., 250(3), 867-874 (1989)!. U.S. Pat. No. 4,816,463 to Blankey et al describes a family of 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-tetrahydro-pyridine derivatives useful as antihypertensives, some of which are reported to antagonize the binding of labeled angiotensin II to a rat adrenal receptor preparation and thus cause a significant decrease in mean arterial blood pressure in conscious hypertensive rats. EP No. 253,310, published 20 Jan. 1988, describes a series of aralkyl imidazole compounds, including in particular a family of biphenylmethyl substituted imidazoles, as antagonists to the angiotensin II receptor. EP No. 323,841 published 12 Jul. 1989 describes four classes of angiotensin II antagonists, namely, biphenylmethylpyrroles, biphenylmethylpyrazoles, biphenylmethyl-1,2,3-triazoles and biphenylmethyl 4-substituted-4H-1,2,4-triazoles, including the compound 3,5-dibutyl-4- (2'-carboxybiphenyl-4-yl)methyl!-4H-1,2,4-triazole. U.S. Pat. No. 4,880,804 to Carini et al describes a family of biphenylmethylbenzimidazole compounds as angiotensin II receptor blockers for use in treatment of hypertension and congestive heart failure.

There are several families of 1,2,4-triazole compounds having substituents attached to the nitrogen atom at the one-position of the 1H-triazole. For example, U.S. Pat. No. 4,118,487 to Regel et al describes a family of azol-1-yl-methane compounds for use as antimycotic and antibacterial agents including, specifically, the compound (1-biphenyl-4-yl-1-phenyl)methyl-1H-1,2,4-triazole. U.S. Pat. No. 4,381,306 to Regel et al describes a family of hydroxypropyl-triazole compounds for use as antimycotic agents including, specifically, the compound (1,2,4-triazol-1-yl)methyl-4-chlorobenzyl-biphenyl-4-yl-carbinol. U.S. Pat. No. 4,480,114 to Regel describes a family of 2-(4-biphenyl)-2-(halophenyl)-oxirane compounds having antimycotic activity including, specifically, the compound (1,2,4-triazol-1-yl)methyl-4-chlorophenyl-4-chlorobiphenyl-4-yl-carbinol.

However, not much is known about the conformations and interactions of these non-peptide antagonists with the vascular angiotensin II receptors. It has been established in the literature that there are distinct angiotensin II receptor subtypes with differing functions A. T. Chiu et al, Biochem. Biophys. Res. Commun., 165, 196-203 (1989)!. The receptor subtypes affecting vascular constriction is believed to be an important target for the treatment of hypertension P. C. Wong et al, J. Pharmacol. Exp. Ther., 255, 584-592 (1990)!. Compounds which conformationally restrict the possible orientations of the pharmacophores incorporated therein may maximize the interaction between those pharmacophores and the binding site of the receptor subtype or subtypes of interest. Therefore, conformationally restricted angiotensin II antagonists may increase the selectivity to the specific receptor subtype of interest, thereby reducing possible side effects associated with binding to the other receptor subtypes not involved in the hypertension pathway.

There are several families of conformationally restricted angiotensin II antagonists reported in the literature. For example, tricyclic benzoxazepines A. P. Thomas et al, J. Med. Chem., 35, 877-885 (1992)! are described to potentially lock in a phenyl group in an energetically favorable conformation. P. A. Carpino et al Biorg.& Med. Chem. Lett., 4, 93 (1994)! describe conformationally restricted compounds incorporating fused rings between a pyridylimidazole and a tetrazolylphenyl radical. Conformationally restricted imidazoles having a biphenyl radical substituted with bulky side groups to sterically limit the rotation of the phenyl groups and form a more rigid spatial relationship are described in P. R. Bovy et al, J. Med. Chem., 34, 2410-2414 (1991). These previous attempts to lock the conformation of angiotensin II antagonists do not stabilize conformations axial to a heterocyclic ring by means of orthogonally attaching a substituted biphenyl radical to a non-aromatic bridging ring.

DESCRIPTION OF THE INVENTION

A series of bicyclic-substituted biphenylmethylene-type compounds which exhibit angiotensin II antagonism are disclosed herein, where the compounds lock the conformation around the methylene group to better mimic high affinity angiotensin II binding site conformations. Specifically, this invention relates to compounds comprising a substituted biphenylmethylene radical attached in a conformationally restricted manner through incorporation in a heterocyclic fused ring system. More specifically, this invention relates to compounds comprising a substituted biphenyl radical attached directly to a heterocyclic fused ring system. Even more specifically, angiotensin II antagonists are described wherein the biphenyl radical may contain an acidic radical such as a tetrazole radical.

Even more specifically, the invention relates to compounds of Formula I ##STR1## wherein W is N or CH₂ ; wherein X is N or CR² ;

wherein Y is (CH₂)_(n) and n is 1 to 3;

wherein Z is C═R³ or CR⁴ R⁵, or

wherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --;

wherein R¹ is alkyl;

wherein R² is selected from hydrido, halo, alkyl and aryl;

wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene;

wherein R⁴ is selected from hydrido, alkyl, amino, hydroxyalkyl, carboxyl, carboxyalkyl, aryl, aralkyl, alkylcarboxyalkyl, hydroxyl, carboxyaralkyl, phthalimidyl, aralkoxy, ##STR2## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, hydroxyalkyl, carboxyalkyl, carboxyl, alkylcarboxyalkyl, aryl and aralkyl;

wherein R⁷ is hydrido or halo;

wherein R⁸ is selected from hydrido, alkyl and aralkyl;

wherein R⁹ is selected from alkyl, aryl, aralkyl, carboxyl, hydrazidylcarboalkyl and carboxyalkyl;

wherein R¹⁰ is hydrido or alkyl;

wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl and carboxyl, or

wherein R¹⁰ and R¹¹ taken together is ═O;

wherein R¹² is hydrido or alkyl; and

wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl and carboxyl, or

wherein R¹² and R¹³ taken together is ═O;

or a pharmaceutically suitable salt or tautomer thereof.

The compounds of Formula I are further substituted wherein R⁴ is selected from aryl or aralkyl only when R² if present is hydrido or halo; wherein R⁴ is alkyl when R⁵ is hydroxyl; wherein R⁸ is aralkyl when R², if present, is hydrido or halo; wherein R⁹ and R⁸ are not both aralkyl; and wherein R¹¹ and R¹³ is alkyl when R² is aryl or halo; or a pharmaceutically suitable salt thereof.

More specifically, the compounds of Formula I are further substituted wherein R¹ is n-propyl or n-butyl; wherein R² is selected from hydrido, chloro, methyl, ethyl, n-propyl and n-butyl, 2-ethylphenyl and 2,6-dimethylphenyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, hydroxyl, hydroxymethyl, phenylmethoxy, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, amino, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, phenethyl, phenyl, --(CH₂ C₆ H₅)CH₂ CO₂ H, 2-ethylphenyl, benzyl, 2,6-dimethylphenyl, ##STR3## provided R⁴ is selected from phenyl, benzyl and phenethyl only when R², if present, is hydrido or chloro; wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, fluoro, chloro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹⁰ and R¹¹ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹² and R¹³ taken together is ═O; or a pharmaceutically suitable salt thereof.

Within Formula I there is a sub-class of compounds represented by compounds of Formula II ##STR4## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, or

wherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --;

wherein R¹ is alkyl;

wherein R² is selected from hydrido, halo, alkyl and aryl;

wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene;

wherein R⁴ is selected from hydrido, alkyl, amino, hydroxyalkyl, carboxyl, carboxyalkyl, alkylcarboxyalkyl, aryl, aralkyl, hydroxyl, aralkoxy, carboxyaralkyl, phthalimidyl, ##STR5## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, carboxyalkyl, alkylcarboxyalkyl, aryl, and aralkyl;

wherein R⁷ is hydrido or halo;

wherein R⁸ is selected from hydrido, alkyl and aralkyl;

wherein R⁹ is selected from alkyl, aryl, aralkyl, carboxyl, carboxyalkyl and hydrazidylcarboalkyl;

wherein R¹⁰ is hydrido or alkyl;

wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹⁰ and R¹¹ taken together is ═O;

wherein R¹² is hydrido or alkyl;

wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹² and R¹³ taken together is ═O;

or a pharmaceutically suitable salt thereof.

The compounds of Formula II are further substituted wherein R⁴ is aryl or aralkyl only when R² is hydrido or halo; wherein R⁴ is alkyl when R⁵ is hydroxyl; wherein R⁷ is aralkyl when R², if present, is hydrido or halo; wherein R⁸ and R⁹ are not both aralkyl; wherein R¹¹ is alkyl when R² is aryl or halo; and wherein R¹³ is alkyl when R² is aryl or halo; or a pharmaceutically suitable salt thereof.

A more preferred class of compounds consists of those compounds of Formula II wherein R⁶ is selected from hydrido, ethyl, hydroxymethyl, --CH₂ CO₂ H, and --(CH₂)₃ CO₂ H, or R⁶ is aryl or aralkyl, provided R² is hydrido, and R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H and CHCO₂ C(CH₃)₃ ; or a pharmaceutically suitable salt thereof.

An even more preferred class of compounds consists of those compounds of Formula II wherein R¹ is n-propyl or n-butyl; wherein R² is selected from hydrido, chloro, methyl, ethyl, n-propyl, n-butyl, 2-ethylphenyl and 2,6-dimethylphenyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --(CH₂ C₆ H₅)CO₂ H, --(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl, benzyl, phenylmethoxy, ##STR6## provided R⁴ is selected from phenyl, benzyl and phenethyl only when R² is hydrido or chloro; wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, fluoro, bromo, chloro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R² is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or herein R¹⁰ and R¹¹ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹² and R¹³ taken together is ═O; or a pharmaceutically suitable salt thereof.

A family of specific compounds of particular interest within Formula II consists of compounds and pharmaceutically-acceptable salts thereof, as follows:

1,3-dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

7-bromo-1,3-dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

1,3-dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

1,3-dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-ol;

1,3-dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-one;

1,3-dibutyl-5,6-dihydro-8-phenyl-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

1,3-dibutyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-ylidene!acetic acid;

1- 1,3-dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!-2,5-pyrrolidinedione;

4- 1,3-dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!amino!-4-oxobutanoic acid, hydrazide;

1,3-dibutyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-5H-imidazo 1,5-a!azepine;

3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-one;

3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-ol;

3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-trans-8-ol;

1,1-dimethylethyl 3-butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-ylidene!acetate;

3-butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-ylidene!acetic acid;

1,1-dimethylethyl 3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-acetate;

3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-acetic acid;

1,1-dimethylethyl 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-acetate;

3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-acetic acid;

1,3-dibutyl-5,6-dihydro-N-hydroxy-5- 2'-(1H-tetrazol-5-yl) 1.1'-biphenyl!-4-yl!imidazol 1,5-a!pyridin-8(7H)-imine;

1- 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!phthalimide;

3-butyl-5,6,7,8-tetrahydro-8-amino-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

1,3-dibutyl-8-phenyl-5,6-dihydro-5-{2'-(1H-tetrazol-5-yl){1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine;

1- 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!-cis-2,5-pyrrolidinedione;

1- 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!-trans-2,5-pyrrolidinedione;

1- 3-butyl-1-chloro-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin -8-yl!-cis-2,5-pyrrolidinedione;

1- 3-butyl-1-chloro-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!-trans-2,5-pyrrolidinedione; and

3-butyl-8-phenylmethoxy-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine.

Within Formula I there is another sub-class of compounds as represented by compounds of Formula III ##STR7## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, or

wherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --;

wherein R¹ is alkyl;

wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene;

wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, alkylcarboxyalkyl, hydroxyl, amino, phthalimidyl, aralkoxy, ##STR8## wherein R⁵ is hydrido or hydroxyl wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl and aralkyl;

wherein R⁷ is hydrido or halo;

wherein R⁸ is selected from hydrido, alkyl and aralkyl;

wherein R⁹ is selected from alkyl, aryl, aralkyl, carboxyl and carboxyalkyl;

wherein R¹⁰ is hydrido or alkyl;

wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹¹ and R¹⁰ taken together is ═O;

wherein R¹² is hydrido or alkyl; and

wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹² and R¹³ taken together is ═O;

or a pharmaceutically suitable salt thereof.

A more preferred class of compounds consists of those compounds of Formula III wherein R⁴ is alkyl when R⁵ is hydroxyl, and wherein R⁸ and R⁹ are not both aralkyl; and wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; or a pharmaceutically suitable salt thereof.

An even more preferred class of compounds consists of those compounds of Formula III wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, benzyl, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, amino, phenethyl, phenyl, ##STR9## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --(CH₂ C₆ H₅)CO₂ H, --(C₂ H₅)CH₂ CO₂ H, --(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, chloro, fluoro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.

Within Formula I, another preferred sub-class of compounds is represented by compounds of Formula IV ##STR10## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, or

wherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --;

wherein R¹ is alkyl;

wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene;

wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, phthalimidyl, alkylcarboxyalkyl, aryl, aralkyl, hydroxyl, amino, aralkoxy, ##STR11## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl, and aralkyl;

wherein R⁷ is hydrido or halo;

wherein R⁸ is selected from hydrido, alkyl and aralkyl;

wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl;

wherein R¹⁰ is hydrido or alkyl;

wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹¹ and R¹⁰ taken together is ═O;

wherein R¹² is hydrido or alkyl; and

wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹² and R¹³ taken together is ═O;

or a pharmaceutically suitable salt thereof.

A more preferred class of compounds consists of those compounds of Formula IV wherein R⁴ is alkyl when R⁵ is hydroxyl and wherein R⁸ and R⁹ are not both aralkyl; wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; and wherein R³ is selected from C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, CHCO₂ H and CHC₂ H₅ ; or a pharmaceutically suitable salt thereof.

An even more preferred class of compounds consists of those compounds of Formula IV wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl, phenethyl, benzyl, ##STR12## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, chloro, iodo and fluoro; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.

Within Formula I thereis a fourth sub-class of compounds of interest which consists of compounds as represented by Formula V ##STR13## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, or

wherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --;

wherein R¹ is alkyl;

wherein R² is selected from hydrido, halo, alkyl and aryl;

wherein R³ is selected from oxygen, sulfur, alkylidene, alkylcarboxyalkylidene, carboxyalkylidene and hydroxyamino;

wherein R⁴ is selected from hydrido, alkyl, amino, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, hydroxyl, phthalimidyl, aralkoxy, ##STR14## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, aryl, and aralkyl;

wherein R⁷ is halo or hydrido;

wherein R⁸ is selected from hydrido, alkyl and aralkyl;

wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl;

wherein R¹⁰ is hydrido or alkyl;

wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹⁰ and R¹¹ taken together is ═O;

wherein R¹² is hydrido or alkyl; and

wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or

wherein R¹³ and R¹² taken together is ═O;

or a pharmaceutically suitable salt thereof.

A more preferred class of compounds consists of those compounds of Formula V wherein R⁴ is aryl or aralkyl only when R² is hydrido or halo; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ C(CH₃) and CHCO₂ H; wherein R⁴ is alkyl where R⁵ is hydroxyl; wherein R⁸ is aralkyl where R², if present, is hydrido or halo; wherein R⁸ and R⁹ are not both aralkyl; wherein R¹¹ is alkyl when R² is aryl or halo; and wherein R¹³ is alkyl when R² is aryl or halo; or a pharmaceutically suitable salt thereof.

A further preferred class of compounds consists of those compounds of Formula V wherein R⁶ is selected from hydrido, ethyl, hydroxymethyl, --CH₂ CO₂ H and --(CH₂)₃ CO₂ H; or is aryl or aralkyl provided R² is hydrido; or a pharmaceutically suitable salt thereof.

An even more preferred class of compounds consists of those compounds of Formula V wherein R¹ is n-propyl or n-butyl; wherein R² is selected from hydrido, chloro, methyl, ethyl, n-propyl, n-butyl, 2-ethylphenyl and 2,6-dimethylphenyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl phenethyl, benzyl, ##STR15## provided R⁴ is selected from phenyl, benzyl and phenethyl only when R₂ is hydrido or chloro; wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, propyl, hydroxylethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, chloro, bromo, fluoro and iodo;

wherein R⁸ is selected from hydrido, methyl, ethyl, propyl, and benzyl, provided that R⁸ is benzyl where R² is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.

The term "conformationally restricted" denotes a compound having a reduced number of possible geometries a radical can attain within the molecule. These limited conformations or orientations of the radical of interest in spatial relationship to other portions of the molecule can impact the potency of such compounds by better mimicking the binding conformation of the target, such as a receptor or enzyme. Certain radicals such as aralkyl and those including alkyl bridges, account for a substantial range of potential conformations, such as by rotation around a single methylene.

The phrase "acidic" such as used to define the substituents on the biphenyl radical is intended to embrace chemical groups which, when attached to the biphenyl radical of Formula I, confers acidic character to the compound of Formula I. "Acidic character" means proton-donor capability, that is, the capacity of the compound of Formula I to be a proton donor in the presence of a proton-receiving substance, such as water. Typically an acidic group should be selected to have proton-donor capability such that the product compound of Formula I has a pK_(a) in a range from about one to about nine. More typically the compound of Formula I has a pK_(a) in a range from about two to about seven. An example of an acidic group containing at least one acidic hydrogen is a carboxyl group (--COOH) or a tetrazolyl radical.

The term "alkyl", alone or in combination, means a straight-chain or branched-chain alkyl radical containing from 1 to about 10, preferably from 1 to about 8, carbon atoms. Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isoamyl, hexyl, octyl and the like. The term "alkenyl", alone or in combination, means a straight-chain or branched-chain hydrocarbon radial having one or more double bonds and containing from 2 to about 18 carbon atoms preferably from 2 to about 8 carbon atoms. The alkenyl radical may be attached through a double bond to a carbon atom in the fused ring. Examples of suitable alkenyl radicals include ethenyl, propenyl, allyl, 1,4-butadienyl and the like. The term "aryl", alone or in combination, means a carbocyclic aromatic system containing one, two or three rings wherein such rings may be attached together in a pendent manner or may be fused. Examples of "aryl" include phenyl or naphthyl radicals either of which optionally carries one or more substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, nitro and the like, as well as p-tolyl, 4-methoxyphenyl, 4-(tert-butoxy)phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-hydroxyphenyl, 1-naphthyl, 2-naphthyl, and the like. The term "heterocyclic ring system" means a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle which contains one or more hetero atoms as ring atoms, selected from nitrogen, oxygen, silicon and sulfur, which is optionally substituted by halogen, alkyl, alkoxy, oxo and the like. Examples of such heterocyclic groups are pyrrolidinyl, imidizolyl, triazolyl, piperidinyl, piperazinyl, morpholinyl, thiamorpholinyl, pyrrolyl, phthalimidyl, succinimidyl, maleimidyl and the like. The term "heterocyclic fused ring system" means a heterocyclic ring as described above, fused to a second ring at more than one ring position. Examples of such fused ring systems include imidazopyridines, dihydroimidazopyridines, tetrahydroimidazopyridines, imidazoazepines, dihydroimidazoazepines, tetrahydroimidazoazepines, triazolopyridines, dihydrotriazolopyridines, tetrahydrotriazolopyridines, triazoloazepines, dihydrotriazoloazepines, tetrahydrotriazoloazepines, indolizines, dihydroindolizines, tetrahydroindolizines, pyrroloazepines, dihydropyrroloazepines, and tetrahydropyrroloazepines. The term "alkoxy" embraces linear or branched oxy-containing radicals each having alkyl portions of one to ten carbon atoms, such as a methoxy group. The term "aralkoxy" means a radical having an aryl group attached to an alkoxy radical as described above. Phenylmethoxy is an example of sauc a radical. The term "halo" means fluorine, chlorine, bromine or iodine. The term "aralkyl", alone or in combination, means an alkyl radical as defined above in which one hydrogen atom is replaced by an aryl radical as defined above, such as benzyl, 2-phenethyl and the like. The term "carboxyalkenyl" means a radical containing an acidic --CO₂ H group attached to one carbon atom of an alkenyl group as defined above, another carbon of the alkenyl group connected via a double bond to a carbon atom on the fused ring. Examples of such "carboxyalkenyl" groups include CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(C₂ H₅)CO₂ H and C(CH₂ C₆ H₅)CH₂ CO₂ H. The term "alkylcarboxyalkenyl" means an ester radical containing an alkyl group, as defined above, attached via a carbon atom to a "carboxyalkenyl" group as defined above. Examples of such "alkylcarboxyalkenyl" groups include CHCO₂ C(CH₃)₃. "Hydroxyalkyl" means a hydroxy substituted alkyl group wherein the hydroxy group is attached to an alkyl group as defined above. Examples of such "hydroxyalkyl" groups include --CH₂ OH, --(CH₂)₂ OH and --(CH₂)₄ OH. "Carboxyalkyl" means a radical containing an acidic --CO₂ H carboxy group attached via the carbon atom to an alkyl group as defined above. Examples of such "carboxyalkyl" groups include --CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(C₂ H₅)CO₂ H and CH(CH₂ C₆ H₅)CH₂ CO₂ H. (CH₂)₃ CO₂ H, --(CH₂)₂ CO₂ H and --CH(CH₂ C₆ H₅)CO₂ H. The term "alkylcarboxyalkyl" means a radical containing an alkyl group, as defined above, attached via a carbon atom to a "carboxyalkyl" group as defined above. Examples of such "alkylcarboxyalkyl" groups include (CH₃)₃ CO₂ CCH₂ --. "Carboxyaralkyl" means a radical containing an acidic --CO₂ H carboxy group attached via the carbon atom to an aryl portion of an aralkyl group as defined above. Examples of such "carboxyaralkyl" groups include --CH₂ C₆ H₄ CO₂ H. The term "hydrido" denotes a single hydrogen atom (H). This hydrido group may be attached, for example, to an oxygen atom to form a hydroxyl group or two hydrido groups may be attached too a carbon atom to form a methylene (--CH₂) radical. The term "hydroxyamino" embraces singly or multiply hydroxy substituted amine groups, including NOH. "Hydrazidocarboalkyl" denotes a radical having a carbonyl between a hydrazine portion and an alkyl portion, and includes --(CH₂)₂ --CONHNH₂.

Also included in the family of compounds of Formula I are isomeric forms including diastereoisomers, regioisomers, tautomers and the pharmaceutically-acceptable salts thereof. The term "pharmaceutically-acceptable salts" embraces salts commonly used to form alkali metal salts and to form addition salts of free acids or free bases. The nature of the salt is not critical, provided that it is pharmaceutically-acceptable. Suitable pharmaceutically-acceptable acid addition salts of compounds of Formula I may be prepared from an inorganic acid or from an organic acid. Examples of such inorganic acids are hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric and phosphoric acid. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic and sulfonic classes of organic acids, example of which are formic, acetic, malic, propionic, succinic, glycolic, gluconic, lactic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzoic, anthranilic, p-hydroxybenzoic, salicyclic, phenylacetic, mandelic, embonic (pamoic), methansulfonic, ethanesulfonic, 2-hydroxyethanesulfonic, pantothenic, benzenesulfonic, toluenesulfonic, sulfanilic, mesylic, cyclohexylaminosulfonic, stearic, algenic, β-hydroxybutyric, malonic, galactaric and galacturonic acid. Suitable pharmaceutically-acceptable base addition salts of compounds of Formula I include metallic salts made from aluminium, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine) and procaine. All of these salts may be prepared by conventional means from the corresponding compound of Formula I by reacting, for example, the appropriate acid or base with the compound of Formula I.

General Synthetic Procedures

General synthetic methods for preparing the compounds of the invention are illustrated in the following Schemes. It is understood by those familiar with the art of organic synthesis that some functionality present in certain compounds of the invention may be incompatible with a particular synthetic sequence. Depending on the reactions and techniques employed, an alternative route, an altered order of steps, or a strategy of protection and deprotection may be necessary to prepare those compounds. In all cases, to achieve optimal yields the reaction conditions (such as reagents, solvent, temperature, and time) may need some modification.

1,5-a!Imidazole-based conformationally restricted angiotensin II antagonists may be prepared as shown in Scheme I to Scheme IV. Isomeric 1,2-a!imidazole-based conformationally restricted angiotensin II antagonists may be prepared as shown in Scheme V to Scheme VIII. Pyrrole-based conformationally restricted angiotensin II antagonists may be prepared as shown in Scheme IX to Scheme XII. Triazole-based conformationally restricted angiotensin II antagonists may be prepared as shown in Scheme XIII to Scheme XVI.

Abbreviations Used in Schemes and Procedures

Reagents:

NBS N-bromosuccinimide

AIBN azo(bis)isobutyronitrile

HOAc acetic acid

NaOAc sodium acetate

TEA triethylamine

Abbreviations Used in Schemes and Procedures

Reagents:

PPh₃ triphenylphosphine

TFA trifluoroacetic acid

LDA lithium diisopropylamide

KOt-Bu potassium tert-butoxide

Solvent:

DME 1,2-dimethoxyethane

DMF N,N-dimethylformamide

DMSO dimethylsulfoxide

IPA isopropanol

EtOAc ethyl acetate

THF tetrahydrofuran

Other:

BOC tertiary butoxycarbonyl

SEM 2-trimethylsilyl-ethoxymethyl

MS (FAB) or FABMS Fast atom bombardment mass spectroscopy

LG leaving group, e.g. halide, tosylate, triflate, etc.

n- normal-

Ph phenyl

PLG leaving group or a functional group

that can be easily converted to a

leaving group

rt room temperature

sec- secondary-

tert- or t- tertiary-

Tf SO₂ CF₃

TMS trimethylsilyl

Tosylate (TsO) OSO₂ -(4-methyl)phenyl

Triflate (TfO) OSO₂ CF₃

Trityl triphenylmethyl

Ts SO₂ -(4-methyl)phenyl

An appropriately substituted imidazole 1, the heterocyclic starting material, may be prepared as described in the literature Klaus Hofmann, in "Imidazole and its Derivatives" of The Chemistry of Heterocyclic Compounds, Arnold Weissberger Ed., Wiley Interscience New York, 1953!. The imidazole 1 in N,N-dimethylformamide (DMF) is treated with base, such as potassium tert-butoxide, followed by addition of appropriate alkylating agent 2 to give the coupled product 3 (Scheme I). For compounds where X is a substituted phenyl group, several procedures have been published for the preparations of the alkylating agent 2 a) D. J., Carini; J. V. Duncia, Eur. Pat. Appl. 253310, 1988; b) D. J. Carini; J. V. Duncia; P. E. Aldrich; A. T. Chiu; A. L. Johnson; M. E. Pierce; W. A. Price; J. B. Santella; G. J. Wells; R. R. Wexler; P. C. Wong; S. E. Yoo; P. B. M. W. Timmermans, J. Med. Chem., 34, 2525-2547 (1991)!.

The coupled imidazole 3 itself may be an angiotensin II receptor antagonist, but it may also be used as a key intermediate in the preparation of the compounds of the invention. Imidazole 3 in THF (or DME) is treated with base (such as n-BuLi or LDA) at -78° C. (or -65° C., if DME is used as solvent), followed by addition of an appropriate alkylating agent or other electrophiles 4 (the acetal shown in Scheme I may be other aldehyde masking group or equivalent, and LG is a leaving group such as halide, mesylate, triflate or tosylate). The resulting masked aldehyde 5 was stirred with NaOAc in aqueous acetic acid at reflux for a few days (1 to 5 days) to give one of the compounds of the invention, a cyclized imidazole 6. ##STR16##

The imidazole 6 may be used as an intermediate to prepare other substituted compounds with appropriate functional group transformations and preparation of some of those compounds are illustrated in Scheme II and III (all of the intermediates shown in the sequences are also angiotensin II receptor antagonists). For example, The unsaturated imidazole 6 and NBS in CCl₄ is stirred at reflux to give a bromide 7. The imidazole 6 may be hydrogenated to give its saturated product 9. ##STR17##

Alternatively, as illustrated in Scheme III, the unsaturated imidazole 6 may be treated with NBS in wet DMSO to give a bromohydrin which may be reduced with nBu₃ SnH to an alcohol 10 and the oxidation of the alcohol with MnO₂ will afford a ketone 11. The ketone 11 may be condensed with appropriately substituted amine, then reduced to an amine 12 with an appropriate reducing agent (e.g. NaBH₄, or hydrogen over catalyst). The amine 12 may also be prepared directly from olefin 6 under bromination condition (NBS, CH₃ CN) in the presence of large excess of succinimide. The amine 12 may be used to prepare other derivatives. Alternatively, the alcohol 10 may be treated with triphenylphosphine, diethoxyazo dicarboxylate and an imide (e.g. phthalimide) to give an imide analogue which may be converted to an amine 12 Mitsunobu, O. Synthesis, 1981, 1-27!.

The ketone 11 may be treated with appropriate organometallic reagents (such as Grignard, organolithium, organocerium, organozinc reagents or related reagents) to give the addition product, a tertiary alcohol a) T. Imamoto; T. Kusumoto; Y. Tawarayama; Y. Sugiura; T. Mita; Y. Hatanaka; M. Yokoyama, J. Org. Chem., 49, 3904-3912 (1984). b) D. Bonneville, J. Org. Chem., 6, 462 (1941). c) T. Hirao; D. Misu; K. Yao; T. Agawa, Tetrahedron Letter, 27, 929-932 (1986)!. The alcohol may be dehydrated to give an olefin 13 or an isomeric mixture of olefins 13. The olefin 13 may be treated with base, such as LDA and kinetically quenched at low temperature with either organic acid or appropriate electrophile at low temperature to give the isomerized olefin 14. The olefins 13 or 14 may be hydrogenated to its saturated analogue 15. Alternatively, olefin 14 can be prepared from ketone 11 by treatment with an appropriate organometallic reagent, such as a Grignard reagent. ##STR18##

In Scheme IV, an alternative preparation for the compounds of the invention is described. An appropriately substituted imidazole 1 may be treated with one equivalent of base, then protected as SEM or BOC derivative. The protected imidazole then is treated with another equivalent of base a) B. H. Lipshutz; B. Huff; W. Hagen, Tetrahedron Letter, 29, 3411-3414 (1988). b) C. C. Tang; D. Davalian; P. Huang; R. Breslow, J. American Chemical Society, 100, 3918 (1978)! followed by addition of electrophile 17 or 18. Electrophiles 17 and 18 can be prepared from HC(═O)(CR⁴ R⁵)(CH₂)_(n) C(═O)LG and an appropriate organometallic reagent such as XC₆ H₄ MgBr. If necessary, the resulting lithium anion obtained from the procedure described above may be converted to other organometallic reagents according to well-established procedures a) T. Imamoto; T. Kusumoto; Y. Tawarayama; Y. Sugiura; T. Mita; Y. Hatanaka; M. Yokoyama, J. Org. Chem., 49, 3904-3912 (1984) b) D. Bonneville, J. Org. Chem., 462 (1941) c) T. Hirao; D. Misu; K. Yao; T. Agawa, Tetrahedron Letter, 27, 929-932 (1986)!.

If PLG is a hydroxyl group and Z is a proton, the resulting addition product 19, may be cyclized with triphenylphosphine and diethyl azodicarboxylate O. Mitsunobu, Synthesis, 1981, 1-27!. If PLG is or is converted to a leaving group, such as halides, tosylate, and Z is a proton, the cyclization may be achieved with a weak base in DMF (e.g. K₂ CO₃, Cs₂ CO₃) to give a ketone 11. The ketone 11 may be reduced to an alcohol 10 with NaBH₄ in methanol. The alcohol 10 may be dehydrated to olefin 6 with acid (e.g. HOAc and heat) or thionyl chloride and pyridine. Other compounds may be prepared from compounds 6, 10, or 11 as described in Scheme II and III. ##STR19##

EXAMPLE 1 ##STR20## 1,3-Dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

Step 1: Preparation of 2,4-dibutylimidazole

A mixture of 12 g (0.09 mol) of ethyl valeryl imidate, 8.6 g (0.074 mol) of 1-hydroxy-2-hexanone, and 100 mL of liquid ammonia was heated in a bomb at 100° C. for 12 h. The bomb was cooled, vented, and the contents were concentrated. The residue was purified by chromatography, eluting with chlorform-ethyl acetate-TEA to give 7.2 g (44%) of the desired biphenyl dibutylimidazole intermediate as a brown oil: ¹ H NMR (CDCl₃) δ 0.91 (t, J=7.31 Hz, 6H), 1.36 (septet, J=7.38 Hz, 4H), 1.50-1.75 (m, 4H), 2.55 (t, J=8.01 Hz, 2H), 2.68 (t, J=8.01 Hz, 2H), 6.61 (s, 1H).

Step 2: Preparation of biphenyl imidazole

To a solution of 478 mg (2.65 mmol) of 2,4-dibutylimidazole (obtained from Step 1) in 5.3 mL of DMF was added 3.45 mL (3.45 mmol) of potassium tert-butoxide (1M in THF), and the resulting solution was stirred at room temperature for 30 min. To the dark brown mixture was added 2.75 g (3.45 mmol) of the bromomethyl biphenyl. The reaction mixture was stirred at room temperature for 12 h, and concentrated in vacuo. The residue was purified by chromatography to give 737 mg (42%) of the trityl-protected biphenyl imidazole as a yellow oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.89 (q, J=7.5 Hz, 6H), 1.23-1.45 (m, 4H), 1.50-1.73 (m, 4H), 2.53 (quintet, J=8.2 Hz, 4H), 4.85 (s, 2H), 6.36 (s, 1H), 6.79 (d, J=8.1 Hz, 2H), 6.92 (d, J=7.8 Hz, 6H), 7.09 (d, J=8.1 Hz, 2H), 7.16-7.40 (m, 10H), 7.40-7.55 (m, 2H), 7.94 (dd, J=6.9, 2.1 Hz, 1H).

Step 3: Preparation of dimethyl acetal imidazole

To a solution of 2.09 g (3.18 mmol) of the biphenyl imidazole (obtained from Step 2) in 16 mL of DME cooled at -45° C. (acetonitrile-dry ice) was added 2.8 mL of 1.45M (4.06 mmol) of n-butyllithium in hexane over a 4 min period. The resulting dark purple solution was stirred cold for another 15 min, followed by addition of 1.0 mL (6.59 mmol) of 3-bromopropionaldehyde dimethyl acetal in one portion. The mixture was stirred cold for 40 min, then was warmed to -10° C. over a 40 min period. The reaction was quenched with aqueous NH₄ Cl, extracted with three 20 mL portions of diethyl ether. The combined extracts were washed with brine, dried (MgSO₄) and concentrated in vacuo. The crude acetal biphenyl imidazole was used directly in the subsequent Step 4 without purification. The ¹ H NMR spectrum of the crude mixture indicated a >9:1 ratio of the desired alkylated product to the recovered starting material (based on the integration areas of singlet peaks at δ 6.48 and 6.28, respectively). HPLC analysis also agreed with the result from the ¹ H NMR study (C₁₈ column, 60% acetonitrile in water containing 0.05% of TFA, flow rate 1.5 mL/min, retention time 8.45 min and 7.21 min, respectively).

In some experiments, the acetal biphenyl imidazole was isolated by chromatography (SiO₂) as a pale yellow oil: ¹ H NMR (CDCL₃) δ 0.75-1.0 (m, 6H), 1.2-1.45 (m, 4H), 1.45-1.72 (m, 6H), 1.85-2.10 (m, 2H), 2,54 (t, J=7.04 Hz, 4H), 3.26 (s, 3H), 3.27 (s, 3H), 4.31 (t, J=5.45 Hz, 1H), 4.98 (dd, J=9.82, 4.95 Hz, 1H), 6.55 (s, 1H), 6.80-7.00 m (with d at 6.89, J=7.31 Hz), 8H!, 7.09 (d, J=8.08 Hz, 2H), 7.15-7.40 (m, 10H), 7.40-7.55 (m, 2H), 7.94 (dd, J=6.89, 2.16 Hz, 1H); MS(FAB) m/e (relative intensity): 759 (100, M+H), 517 (20), 474 (30).

Step 4: Preparation of bicyclic imidazole

A solution of 2.1 g (3.18 mmol) of the crude biphenyl acetal imidazole (obtained from Step 3) and 5.3 g (88 mmol) of NaOAc in 13 mL of water and 40 mL of glacial acetic acid was stirred at reflux for 64 h, cooled and concentrated in vacuo. The residue was dissolved in methylene chloride and filtered. The filtrate was stirred with 2 g (7.2 mmol) of trityl chloride and 3 mL (21.5 mmol) of TEA at room temperature overnight (16 h) and concentrated in vacuo. The residue was purified by chromatography to give 1.2 g (54%) of trityl-protected biphenyl bicyclic imidazole: ¹ H NMR (CDCl₃) δ 0.78 (t, J=7.25 Hz, 3H), 0.96 (t, J=7.25 Hz, 3H), 1.20 (septet, J=7.65 Hz, 2H), 1.35-1.60 m (with quintet at 1.43, J=7.65 Hz), 4H!, 1.60-1.80 (m, 2H), 2.25 (dd, J=16.9, 6.54 Hz, 1H), 2.32-2.40 (m, 2H), 2.64 (t, J=7.66 Hz, 2H), 2.90 (ddt, J=16.92, 7.25, 2.82 Hz, 1H), 5.2-5.29 m (with d at 5.21, J=6.85 Hz), 2H!, 6.46 (dd, J=9.67, 2.82 Hz, 1H), 6.57 (d, J=8.46 Hz, 2H), 6.88 (d, J=7.65 Hz, 6H), 7.02 (d, J=8.06 Hz, 2H), 7.20-7.38 (m, 10H), 7.38-7.52 (m, 2H), 7.90 (dd, J=6.85, 2.02 Hz, 1H).

Steps: Detritylation of the trityl tetrazole

A solution of 100 mg (0.144 mmol) of the trityl-protected biphenyl bicyclic imidazole (obtained from Step 4) was stirred with 1 mL of water and 6 mL of acetic acid at room temperature for 18 h. The solution was concentrated in vacuo, stirred in 3 mL of aqueous NaHCO₃ and washed with three 3 mL portions of ether. The aqueous residue was acidified with 3N HCl to pH 4 and extracted with methylene chloride. The combined extracts were dried (MgSO₄) and concentrated to give 59 mg of the title compound of Example 1 as an oil which solidified as a glass: mp 140.2°-144.0° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.68 (t, J=7.27 Hz, 3H), 0.83 (t, J=7.3 Hz, 3H), 1.0-1.42 (m, 8H), 2.4-2.7 (m, 5H), 2.9-3.10 (m, 1H), 5.62 (d, J=7.5 Hz, 1H), 5.7-5.82 (m, 1H), 6.52 (dd, J=10, 3 Hz, 1H), 6.69 (d, J=8.01 Hz, 2H), 6.93 (d, J=8.16 Hz, 2H), 7.2-7.5 (m, 4H); HRMS. calcd for M+H: 453.2767. Found: 453.2791.

EXAMPLE 2 ##STR21## 7-Bromo-1,3-dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

Step 1: Preparation of bromo olefin imidazole

A solution of 70 mg (0.101 mmol) of trityl-protected bicyclic imidazole (obtained from Step 4 of Example 1), 20 mg (0.112 mmol) of NBS and 7 mg (catalytic) of AIBN in 2.8 mL of CCl₄ was stirred at reflux for 2 h. The reaction mixture was diluted with CCl₄ and washed with water. The organic layer was dried (MgSO₄) and concentrated in vacuo. The residue was purified by chromatography to give 36 mg of brominated olefin as a yellow solid: ¹ H NMR (CDCl₃) δ 0.76 (t, J=7.35 Hz, 3H), 0.95 (t, J=7.2 Hz, 3H), 1.16 (septet, J=7.38 Hz, 2H), 1.20-1.32 (m, 3H), 1.35-1.55 (m, 4H), 1.60-1.75 (m, 2H), 2.20-2.35 (m, 2H), 2.58 (t, J=7.74 Hz, 2H), 2.69 (dd, J=17.3, 1.21 Hz, 1H), 3.40 (ddd, J=17.33, 7.25, 2.82 Hz, 1H), 5.20 (d, J=7.25 Hz, 1H), 6.60 (d, J=8.05 Hz, 2H), 6.80 (d, J=2.82 Hz, 1H), 6.91 (d, J=7.39 Hz, 6H), 7.05 (d, J=8.31 Hz, 2H), 7.18-7.38 (m, 10H), 7.46 (quintet of doublets, J=6.67, 1.7 Hz, 2H), 7.90 (dd, J=7.03, 2.01 Hz, 1H).

Step 2: Detritylation of the trityl tetrazole

A solution of 33 mg (0.0427 mmol) of bromo olefin (obtained from Step 1) in 0.8 mL of water and 5 mL of acetic acid was stirred at room temperature for 5 h and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 20 mg of the title compound of Example 2 as an oil which solidified as a glass: mp 148°-160° C. (decomposed); ¹ H NMR (CDCl₃) δ 0.68-0.85 (m,6H), 1.0-1.30 (m, 6H), 1.30-1.60 (m, 2H), 1.85-2.08 (m, 2H), 2.20 (septet, J=6.88 Hz, 2H), 2.96 (d, J=17.05 Hz, 1H), 3.39-3.53 (m, 1H), 5.34 (d, J=6.27 Hz, 1H), 6.54 (d, J=8.08 Hz, 2H), 6.63 (d, J=2.78 Hz, 1H), 7.02 (d, J=8.28 Hz, 2H), 7.42 (dd, J=7.57, 1.04 Hz, 1H), 7.45-7.60 (m, 2H), 7.76 (d, J=6.34 Hz, 1H); HRMS. calcd for M+H: 531.1872. Found: 531.1834.

EXAMPLE 3 ##STR22## 1,3-Dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

A suspension of 45 mg (0.1 mmol) of biphenyl bicyclic imidazole (the title compound of Example 1) and 20 mg (0.019 mmol) of 10% palladium on charcoal in 2 mL of absolute ethanol was agitated on a Parr apparatus under 50 psi of hydrogen gas at room temperature for 3.5 h. The mixture was filtered through a pad of celite and concentrated in vacuo to give 39 mg of the title compound of Example 3 as an oil which solidified as a glass: mp 108°-113° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.83 (t, J=7.22 Hz, 3H), 0.98 (t, J=7.26 Hz, 3H), 1.15-1.90 (m, 10H), 2.08-2.23 (m, 1H), 2.35-2.60 (m, 3H), 2.35-2.85 (m, 3H), 2.90-3.05 (m, 1H), 5.72 (br s, 1H), 6.96 (d, J=8.46 Hz, 2H), 7.17 (d, J=8.46 Hz, 2H), 7.50-7.63 (m, 2H), 7.63-7.78 (m, 2H); HRMS. calcd for M+H: 455.2923. Found: 455.2965.

EXAMPLE 4 ##STR23## 1,3-Dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-ol

Step 1: Preparation of the bromohydrin intermediate

To a solution of 1.89 g (2.72 mmol) of biphenyl olefin imidazole (obtained from Step 4 of Example 1) in 1.37 mL (0.076 mmol) of water and 19.6 mL of DMSO at room temperature was added 509 mg (2.86 mmol) of NBS in one portion. The resulting orange solution was stirred at room temperature for 1 h, quenched with 100 mL of water and 12 mL of saturated Na₂ SO₃, extracted with 150 mL of methylene chloride. The combined extracts were washed with two 60 mL portions of water, and the combined aqueous layers were extracted with 40 mL of methylene chloride. The combined extracts were washed with brine, dried (MgSO₄) and concentrated in vacuo to give 2.12 g of the crude bromohydrin which was used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of trityl tetrazolyl hydroxy imidazole

To 2.12 g (2.72 mmol) of the crude bromohydrin (obtained from Step 1) in 42 mL of degassed dry benzene was added 4.3 mL (14.7 mmol) of n-Bu₃ SnH and 400 mg (2.4 mmol) of AIBN in one portion and the resulting solution was stirred at reflux for 2 h. The mixture was concentrated in vacuo and partitioned between 20 mL of hexane and 80 mL of acetonitrile. The acetonitrile layer was washed with two fresh 20 mL portions of hexane, and the combined hexane layer was extracted with another 50 mL of acetonitrile. The combined acetonitrile solution was concentrated in vacuo to give 2.5 g of the crude biphenyl hydroxy imidazole. The crude product was used directly in Example 5 without further purification. However, in some experiment, the crude mixture was purified by chromatography to give trityl-protected biphenyl hydroxy imidazole as a solid: ¹ H NMR (CDCl₃) δ 0.70 (t, J=7.25 Hz, 3H), 0.96 (t, J=7.31 Hz, 3H), 0.98-1.17 (m, 2H), 1.33-1.55 (m, 4H), 1.58-1.85 (m, 4H), 1.90-2.05 (m, 2H), 2.05-2.18 (m, 2H), 2.60-2.75 (m, 2H), 4.96 (br t, J=6.05 Hz, 2H), 6.81 (d, J=8.46 Hz, 2H), 6.92 (d, J=6.84 Hz, 6H), 7.12 (d, J=8.05 Hz, 2H), 7.18-7.40 (m, 10H), 7.5-7.55 (m, 2H), 7.92 (dd, J=7.25 Hz, 2.02 Hz, 1H); MS(FAB) m/e (relative intensity) 713 (75, M+H), 469 (35), 428 (100).

Step 3: Detritylation of trityl-protected imidazole

A Solution of 42 mg (0.059 mmol) of purified trityl tetrazolyl hydroxy imidazole (obtained from Step 2) in 0.8 mL of water and 4 mL of acetic acid was stirred at room temperature for 6 h, and concentrated in vacuo. The residue was dissolved in a minimum amount of methanol, diluted with methylene chloride, then triturated with ether to give 23 mg (82%) of the title compound of Example 4 as a solid: ¹ H NMR (CDCl₃) δ 0.81 (t, J=7.25 Hz, 3H), 0.99 (t, J=7.26 Hz, 3H), 1.18-1.35 (m, 2H), 1.69 (quintet, J=7.26 Hz, 2H), 1.78-1.93 (m, 1H), 1.96-2.10 (m, 1H), 2.17-2.58 (m, 4H), 2.70-2.95 (m, 2H), 4.98 (dd, J=7.25, 5.24 Hz, 1H), 5.59 (t, J=5.0 Hz, 1H), 7.11 (d, J=8.46 Hz, 2H), 7.20 (d, J=8.46 Hz, 2H), 7.50-7.65 (m, 2H), 7.65-7.77 (m, 2H); MS(FAB) m/e (relative intensity): 471 (100, M+H), 443 (13), 428 (30); HRMS. calcd for M+H: 471.2872. Found: 471.2887.

EXAMPLE 5 ##STR24## 1,3-Dibutyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)- one

Step 1: Preparation of trityl-protected keto imidazole

A suspension of 2.5 g (2.72 mmol) of the crude product (obtained from Step 2 of Example 4) and 13 g of active MnO₂ in 18 mL of methylene chloride was stirred at room temperature for 4 days. The mixture was filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in in vacuo. The residue was purified by chromatography to give 0.28 g (15%) of olefinic starting material (the trityl protected title compound of Example 1), 0.73 g (38%) of biphenyl hydroxy imidazole (the trityl protected title compound of Example 4) and 0.32 g (17%) of trityl-protected biphenyl keto imidazole as an oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.77 (t, J=7.25 Hz, 3H), 0.97 (t, J=7.25 Hz, 3H), 1.17 (septet, J=7.25 Hz, 2H), 1.33-1.66 m (with quintet at 1.47, J=7.65 Hz), 4H!, 1.65-1.82 (m, 2H), 2.0-2.25 (m, 3H), 2.36 (t, J=7.65 Hz, 2H), 2.45-2.63 (m, 1H), 3.04 (septet, J=3.8 Hz, 2H), 5.38 (br d, J=3.22 Hz, 1H), 6.62 (d, J=8.05 Hz, 2H), 6.90 (d, J=7.65 Hz, 6H), 7.13 (d, J=8.05 Hz, 2H), 7.18-7.38 (m, 10H), 7.40-7.55 (m, 2H), 7.97 (dd, J=6.44, 2.42 Hz, 1H).

The ¹ H NMR spectrum of the biphenyl hydroxy imidazole obtained from the above purification indicated the presence of another compound which co-eluted with the biphenyl hydroxy imidazole. This mixture was used in Example 8 to provide the title compound of Example 8.

Step 2: Detritylation of trityl-protected imidazole

A solution of 39 mg (0.055 mmol) of trityl-protected keto imidazole (obtained from Step 1) in 0.8 mL of water and 4 mL of acetic acid was stirred at room temperature for 6 h, and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 22 mg (85%) of the title compound of Example 5 as an oil which solidified as a glass: mp 107°-116° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.82 (t, J=7.25 Hz, 3H), 0.95 (t, J=7.25 Hz, 3H), 1.17-1.32 (m, 2H), 1.32-1.58 m (with septet at 1.39, J=7.66 Hz), 4H!, 1.66 (quintet, J=7.25 Hz, 2H), 2.28-2.45 (m, 3H), 2.53 (t, J=7.7 Hz, 2H), 2.59-2.75 (m, 1H), 2.95 (td, J=7.66, 3.62 Hz, 2H), 5.77 (d, J=3.62 Hz, 1H), 6.85 (d, J=8.06 Hz, 2H), 7.14 (d, J=8.46 Hz, 2H), 7.53 (t, J=6.84 Hz, 2H), 7.62 (td, J=6.04, 1.6 Hz, 2H); HRMS. calcd for M+H: 469.2716. Found: 469.2748.

EXAMPLE 6 ##STR25## 1,3-Dibutyl-5,6-dihydro-8-phenyl-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

Step 1: Preparation of phenyl hydroxy imidazole biphenyl

To 105 mg (0.148 mmol) of ketone biphenyl (from step 1 of Example 5) in 1.5 mL of THF at -78° C. was added dropwise 298 μL (0.149 mmol) of phenyllithium (o,5M in cyclohexane/diethyl ether), and the resulting dark brown solution was stirred cold for 2 hour, then was allowed to warm to room temperature and stirred for 10 min. The reaction was quenched with aqueous NH₄ Cl and extracted with methylene chloride. The combined extracts were dried and concentrated in vacuo. The crude product was used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of conjugated phenyl imidazole biphenyl

To 177 mg (0.148 mmol) of phenyl hydroxy imidazole (from Step 1) and 50 μL of pyridine in 1.5 mL of methylene chloride at 0° C. was added 32 μL of thionyl chloride, and the resulting brown solution was stirred at room temperature for 2 hour. The reaction mixture was washed with water, dried and concentrated in vacuo. The residue was purified over silica gel to give 105 mg (92%) of conjugated phenyl imidazole biphenyl as an oil which solidfied upon standing.

Step3: Detritylation of trityl tetrazole

A solution of 105 mg (0.136 mmol) of trityl-protected phenyl imidazole (obtained from Step 2) in 0.5 mL of water and 5 mL of acetic acid was stirred at room temperature for 16 h, and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1. The product obtained was recrystallized to give 51 mg (71%) of the title compound of Example 6 as an solid: mp 158°-170° C. (decomposed); ¹ H NMR (CDCl₃) δ 0.47 (t, J=7.25 Hz, 3H), 0.60-0.87 m (with t at 0.80, J=7.25 Hz), 5H!, 0.88-1.13 (m, 2H), 1.22 (quintet, J=8.06 Hz, 2H), 1.42-1.63 (m, 2H), 1.63-1.85 (m, 2H), 2.12-2.33 (m, 1H), 2.40-2.60 (m, 1H), 2.82 (dd, J=16.5, 7.25 Hz, 1H), 3.07 (dd, J=16.5, 5.24 Hz, 1H), 5.42 (d, J=6.05 Hz, 1H), 5.50 (d, J=6.45 Hz, 1H), 6.73 (d, J=8.06 Hz, 2H), 7.04 (d, J=8.06 Hz, 2H), 7.14-7.22 (m, 2H), 7.38-7.55 (m, 6H), 7.70 (d, J=7.26 Hz, 1H); ¹³ C NMR (CDCl₃) δ 13.12 (CH₃), 13.46 (CH₃), 21.83 (CH₂), 22.21 (CH₂), 24.97 (CH₂), 25.34 (CH₂), 29.56 (CH₂), 31.62 (CH₂), 31.98 (CH₂), 53.29 (CH), 118.87 (CH), 123.17 (C), 124.67 (CH), 126.05 (C), 127.50 (CH), 127.61 (CH), 128.00 (CH), 128.09 (CH), 126.20 (CH), 129.36 (CH), 129.77 (CH), 130.24 (CH), 130.97 (CH), 132.93 (C), 137.35 (C), 137.42 (C), 140.10 (C), 140.34 (C), 146.57 (C), 157.38 (C); MS(FAB) m/e (relative intensity): 529 (100, M+H); HRMS. calcd for M+H: 529.3080. Found: 529.3045.

EXAMPLE 7 ##STR26## 1,3-Dibutyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-ylidene!acetic acid

Step 1: Preparation of the tert-butyl ester

To a suspension of 50 mg (2.058 mmol) of magnesium in 2.5 mL of THF at 45° C. was added 16 μL of 1,2-dibromoethane in two portions, 5 min apart. The resulting mixture was stirred at 45° C. for 10 min, followed by dropwise addition of a solution of 170 mg (0.239 mmol) of biphenyl keto imidazole (obtained from Step 1 of Example 5) and 190 μL (1.18 mmol) of tert-butyl bromoacetate in 1.5 mL of THF at 45° C. over a 1 h period. The resulting solution was stirred for an additional 15 min, and was cooled and quenched with aqueous NH₄ Cl. The mixture was extracted with ether, dried (MgSO₄) and concentrated in vacuo. The crude mixture could be used in the subsequent Step 2 without further purification. In this particular experiment, the crude product was purified by chromatography to give 179 mg (91%) of the hydroxy intermediate: ¹ H NMR (CDCl₃) δ 0.72 (t, J=7.65 Hz, 3H), 0.98 (t, J=7.65 Hz, 3H), 1.11 (septet, J=7.66 Hz, 2H), 1.30-1.55 m (with s at 1.47, 9H), 14H!, 1.65-1.90 (m, 5H), 2.10-2.35 (m, 3H), 2.67 (d, J=15.7 Hz, 1H), 2.72-2.9 m (with d at 2.83, J=15.7 Hz), 2H!, 4.10-4.25 (br s, 1H), 5.13 (d, J=3.22 Hz, 1H), 6.61 (d, J=8.06 Hz, 2H), 6.93 (d, J=7.25 Hz, 6H), 7.08 (8.06 Hz, 2H), 7.18-7.38 (m, 10H), 7.46 (quintet of doublets, J=6.85, 2.02 Hz, 2H), 7.90 (dd, J=6.85, 2.01 Hz, 1H).

Step 2: Preparation of unsaturated tert-butyl ester

To a solution of 115 mg (0.139 mmol) of the biphenyl imidazolyl ester intermediate (obtained from Step 1) and 30 μL (0.371 mmol) of pyridine in 1 mL of methylene chloride at 0° C. was added dropwise 20 μL (0.274 mmol) of thionyl chloride. The resulting dark brown solution was stirred at room temperature for 1 h, diluted with water and extracted with ether. The combined extracts were dried (MgSO₄) and concentrated in vacuo. The residue was purified by chromatography to give 107 mg (95%) of the unsaturated ester intermediate as an oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.75 (t, J=7.25 Hz, 3H), 1.02 (t, J=7.25 Hz, 3H), 1.14 (septet, J=7.25 Hz, 2H), 1.35-1.65 m (with s at 1.47), 13H!, 1.77 (quintet, J=7.25 Hz, 2H), 1.90-2.10 (m, 1H), 2.10-2.25 (m, 2H), 2.29 (t, J=7.65 Hz, 2H), 2.86 (t, J=8.06 Hz, 2H), 3.40-3.60 (m, 1H), 5.26 (s, 1H), 6.00 (s, 1H), 6.60 (d, J=8.06 Hz, 2H), 6.91 (d, J=8.1 Hz, 6H), 7.09 (d, J=8.46 Hz, 2H), 7.18-7.49 (m, 10H), 7.47 (quintet of doublets, J=6.45, 2.01 Hz, 2H), 7.93 (dd, J=6.85, 2.02 Hz, 1H).

Step 3: Detritylation of trityl-protected biphenyl and deprotection of tert-butyl ester group

A solution of 98 mg (0.121 mmol) of trityl tetrazolyl butyl ester (obtained from Step 2) in 0.8 mL of water and 3 mL of acetic acid was stirred at room temperature for 17 h and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give the free tetrazole intermediate. The intermediate was dissolved in 3 mL of CDCl₃ and 1 mL of TFA, and the progress of the reaction was monitored by ¹ H NMR. The resulting yellow solution was stirred at room temperature for 2 h and concentrated in vacuo. The crude product was purified over reverse phase chromatography to give 30 mg of the title compound of Example 7 as a solid: mp 155°-178° C. (decomposed); ¹ H NMR (CD₃₀ D) δ 1.10 (t, J=7.31 Hz, 3H), 1.29 (t, J=7.29 Hz, 3H), 1.40-1.68 (m, 2H), 1.68-1.89 (m, 4H), 1.99 (quintet, J=7.31 Hz, 2H), 2.40-2.75 (m, 3H), 2.78 (t, J=7.93 Hz, 2H), 3.12 (t, J=7.83 Hz, 2H), 3.84 (d, J=16.47 Hz, 1H), 5.91 (s, 1H), 6.44 (s, 1H), 7.07 (d, J=8.08 Hz, 2H), 7.40 (d, J=8.28 Hz, 2H), 7.68-7.78 (m, 2H), 7.78-7.90 (m, 2H); HRMS. calcd for M+H: 511.2821. Found: 511.2769.

EXAMPLE 8 ##STR27## 1- 1,3-Dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!-2,5-pyrrolidinedione

Step 1: Preparation of succinimidyl imidazole

A suspension of 727 mg (1.02 mmol) of impure biphenyl hydroxy imidazole (isolated from Step 1 of Example 5) and 7 g of active MnO₂ in 10 mL of methylene chloride was stirred at room temperature for 3 h. The resulting mixture was filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue was purified by chromatography to give 316 mg (16% from Step 1 of Example 4) of ketone (the trityl-protected title compound of Example 5), and 130 mg (6% from Step 1 of Example 4) of the trityl-protected biphenyl succinimidyl imidazole: ¹ H NMR (CDCl₃) δ 0.70 (t, J=7.31 Hz, 3H), 0.91 (t, J=7.19 Hz, 3H), 1.08 (septet, J=7.5 Hz, 2H), 1.2-1.70 (m, 6H), 1.8-1.9 (m, 1H), 2.1-2.4 (m, 7H), 2.72 (s, 4H), 5.13 (s, 1H), 5.35-5.5 (m, 1H), 6.94 (d, J=6.84 Hz, 6H), 7.09 (d, J=8.34 Hz, 2H), 7.16 (d, J=8.28 Hz, 2H), 7.20-7.55 (m, 12H), 7.86 (dd, J=6.8, 2.6 Hz, 1H).

Alternatively, the succinimide can be prepared from trityl protected title compound of Example 1 (Step 4). To a solution of 2.17 g (3.13 mmol) of biphenyl bicyclic imidazole (Example 1, Step 4) and 1.25 g (12.6 mmol) of succinimide in 20 mL of anhydrous acetonitrile is added 572 mg (3.21 mmol) of NBS in one portion. The resulting orange-red solution is stirred at room temperature for 30 min, then evaporated in vacuo. The residue is dissolved in ethyl acetate and washed with aqueous sodium bisulfite, water,and brine. The extracts are dried (MgSO₄) and concentrated in vacuo. To the resulting crude bromide (3.13 mmol) in 30 mL of degassed dry benzene is added 1.5 mL (5.2 mmol) of n-Bu₃ SnH and 150 mg (0.91 mmol) of AIBN in one portion and the resulting solution is stirred at reflux for 2 h. The mixture is concentrated in vacuo and partitioned between 15 mL of hexane and 15 mL of acetonitrile. The acetonitrile layer is washed with two fresh 12-mL portions of hexane, and the combined hexane layer is extracted with another 15 mL of acetonitrile. The combined acetonitrile solution is concentrated in vacuo and purified to give the the trityl protected succinimidyl imidazole.

Step 2: Detritylation of trityl tetrazolyl imidazole

A solution of 130 mg (0.16 mmol) of trityl-protected biphenyl succinimidyl imidazole (obtained from Step 1) in 0.2 mL of water and 1 mL of acetic acid was stirred at room temperature for 12 h and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 and purified by chromatography to give 64 mg (79%) of the title compound as a solid: mp 166.8°-170.0° C. (decomposed); ¹ H NMR (CD₃ OD) δ 1.10 (t, J=7.3 Hz, 3H), 1.22 (t, J=7.31 Hz, 3H), 1.50 (septet, J=7.4 Hz, 2H), 1.55-1.93 (m, 6H), 2.1-2.25 (m, 1H), 2.4-2.85 (m, 7H), 3.06 (s, 4H), 5.76 (dd, J=8.7, 7.8 Hz, 1H), 5.8-0.59 (m, 1H), 7.46 (d, J=8.35 Hz, 2H), 7.60 (d, J=8.28 Hz, 2H), 7.7-7.9 (m, 4H); HRMS. calcd for M+H: 552.3087. Found: 552.3067.

EXAMPLE 9 ##STR28## 4- 1,3-Dibutyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!amino!-4-oxobutanoic acid, hydrazide

A solution of 34.8 mg (0.06 mmol) of succinimidyl imidazole (the title compound of Example 8) and 11 μL (5.6 mmol) of hydrazine in 0.5 mL of ethanol was stirred at room temperature for 6 days and concentrated in vacuo to give the title compound as a solid: mp 136.5°-139.4° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.68 (t, J=7.23 Hz, 3H), 0.83 (t, J=7.27 Hz, 3H), 1.00-1.43 (m, 6H), 1.40-1.57 (m, 2H), 1.58-1.75 (m, 1H), 1.80-1.93 (m, 1H), 0.198-2.12 (m, 1H), 2.20-2.65 (m, 9H), 5.10 (dd, J=8.77, 5.99 Hz, 1H), 5.54 (br s, 1H), 7.05 (q_(AB), J=8.35 Hz, 4H), 7.35-7.50 (m, 2H), 7.50-7.63 (m, 2H); HRMS. calcd for M+H: 584.3461. Found: 584.3525.

EXAMPLE 10 ##STR29## 1,3-Dibutyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-5H-imidazo 1,5-a!azepine

Step 1: Alkylation of biphenyl imidazole

To a solution of 100 mg (0.152 mmol) of biphenyl imidazole (obtained from Step 2 of Example 1) in 0.8 mL of DME cooled at -45° C. (acetonitrile-dry ice) was added 125 μL of 1.6M (0.2 mmol) of n-butyllithium in hexane over a 4-min period. The resulting dark red solution was stirred cold for another 15 min, followed by addition of 70 μL (0.37 mmol) of 2-(3-bromopropyl)-5,5-dimethyl-1,3-dioxane in one portion. The mixture was stirred cold for 40 min, then was warmed to -10° C. over a 40 min period. The reaction was quenched with aqueous NH₄ Cl, extracted with three 20 mL portions of diethyl ether. The combined extracts were washed with brine, dried (MgSO₄) and concentrated in vacuo. The crude product was used directly in the subsequent Step 2 without purification. The ¹ H NMR spectrum (in CDCl₃) of the crude mixture indicated a >9:1 ratio of the desired alkylated product to the recovered starting material (based on the integration areas of singlet peaks at δ 6.55 and 6.3, respectively). HPLC analysis also agreed with the result from the ¹ H NMR study (C18 column, 60% acetonitrile in water containing 0.05% of TFA, flow rate 1.5 mL/min, retention time 13.5 min and 7.1 min, respectively).

Step 2: Preparation of the bicyclic imidazole

A solution of 135 mg (0.152 mmol) of the crude biphenyl acetal imidazole (obtained from Step 1) and 255 mg (3 mmol) of NaOAc in 0.6 mL of water and 2 mL of glacial acetic acid was stirred at reflux for 22 h, cooled and concentrated in vacuo. The residue was dissolved in methylene chloride and filtered. The filtrate was stirred with 130 mg (0.46 mmol) of trityl chloride and 0.22 mL (1.6 mmol) of TEA at room temperature overnight (16 h) and concentrated in vacuo. The residue was purified by chromatography to give 25 mg (23%) of trityl-protected biphenyl bicyclic imidazole: ¹ H NMR (CDCl₃) δ 0.78 (t, J=7.5 Hz, 3H), 0.87 (t, J=7.4 Hz, 3H), 1.1-1.32 (m, 2H), 1.35-1.60 (m, 4H), 1.62-1.90 (m, 3H), 1.95-2.12 (m, 1H), 2.20-2.38 (m, 2H), 2.38-2.55 (m, 2H), 2.58-2.75 (m, 2H), 5.15-5.38 (m, 1H), 5.53 (br s, 1H), 6.27 (dd, J=17.5, 3 Hz, 1H), 6.68 (d, J=7.5 Hz, 2H), 6.93 (d, J=8.3 Hz, 6H), 7.08 (d, J=7.7 Hz, 2H), 7.20-7.38 (m, 10H), 7.40-7.55 (m, 2H), 7.9 (dd, J=7.5, 3.0 Hz, 1H).

Step 3: Detritylation of trityl tetrazole

A solution of 25 mg (0.035 mmol) of the bipenyl bicyclic imidazole (obtained from Step 2) was stirred with 0.4 mL of water and 2 mL of acetic acid at room temperature for 14 h. The solution was concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 13 mg (80%) of the title compound of Example 10 as an oil which solidified as a glass: mp 125°-130° C. (decomposed); HRMS. calcd for M+H: 467.2923. Found: 467.2944.

EXAMPLE 11 ##STR30## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

Step 1: Preparation of 2-butylimidazole

To a mixture of 72.4 g (0.56 mol) of ethyl valery imidate and 63 mL (0.433 mol) of aminoacetaldehyde diethyl acetal was added slowly 50 mL of glacial acetic acid over a 20 min period, and the resulting solution was stirred at reflux for 2.5 h. To the solution was added 144 mL of 5N HCl aqueous solution, and the resulting mixture was stirred at reflux for another 2 h. The mixture was cooled and concentrated to about 200 mL, washed with 200 mL of ethyl acetate, 200 mL of ether, then basified to pH 8 with 50% NaOH, and extracted with four 225 mL portions of chloroform. The combined extracts were dried (MgSO₄) and concentrated to give 30 g (56%) of 2-butyl imidazole as a light brown solid: ¹ H NMR (CDCl₃) δ 0.85 (t, J=7.31 Hz, 3H), 1.31 (septet, J=7.46 Hz, 2H), 1.73 (quintet, J=7.31 Hz, 2H), 2.86 (t, J=7.39 Hz, 2H), 6.99 (s, 2H), 11.09-12.4 (br s, 1H).

Step 2: Preparation of biphenyl imidazole

To a solution of 4.07 g (32.8 mmol) of 2-butylimidazole (obtained from step 1) in 110 mL of DMF was added 44.3 mL (44.3 mmol) of potassium tert-butoxide (1M in THF), and the resulting solution was stirred at room temperature for 15 min. To the dark brown mixture was added 20.1 g (36.1 mmol) of the bromomethyl biphenyl. The reaction mixture was stirred at room temperature for 16 h, and concentrated in vacuo. The residue was dissolved in chloroform and washed with water. The aqueous layer was extracted with fresh chloroform, and the combined extracts were dried (MgSO₄) and concentrated in vacuo. The residue was purified by chromatography to give 7.2 g (37%) of the biphenyl imidazole intermediate as a yellow oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.90 (t, J=7.31 Hz, 3H), 1.35 (septet, J=7.5 Hz, 2H), 1.71 (quintet, J=7.74 Hz, 2H), 2.61 (t, J=7.58 Hz, 2H), 4.93 (s, 2H), 6.65 (d, J=1.35 Hz, 1H), 6.79 (d, J=8.31 Hz, 2H), 6.92 (d, J=7.3 Hz, 6H), 6.97 (d, J=1.32 Hz, 1H), 7.11 (d, J=8.2 Hz, 2H), 7.2-7.4 (m, 10H), 7.4-7.55 (m, 2H), 7.95 (dd, J=6.85, 2.08 Hz, 1H); MS(FAB) m/e (relative intensity) 607 (100, M+Li), 601 (90, M+H).

Step 3: Alkylation of the biphenyl imidazole

To a solution of 7.5 g (12.5 mmol) of the biphenyl imidazole (obtained from Step 2) in 49 mL of DME and 86 mL of THF cooled at -45° C. (acetonitrile-dry ice) was added 14.8 mL of 1.6M (24 mmol) of n-butyllithium in hexane over a 4 min period. The resulting dark red solution was stirred cold for another 15 min, followed by addition of 3.8 mL (25 mmol) of 3-bromo-proprionaldedyde dimethyl acetal in one portion. The mixture was stirred cold for 1 h, then was allowed to warm to -10° C. over a 1.5-h period. The reaction was quenched with aqueous NH₄ Cl, extracted with methylene chloride. The combined extracts were washed with brine, dried (MgSO₄) and concentrated in vacuo to give the crude acetal biphenyl imidazole. The crude product was used directly in the subsequent Step 4 without purification. The ¹ H NMR spectrum of the crude mixture indicated a 9:1 ratio of the desired alkylated product to the recovered starting material based on the integration areas of peaks at δ 5.13 (dd, 1H) and 4.93 (s, 2H), respectively!.

Step 4: Preparation of the bicyclic imidazole

The crude mixture (12.5 mmol, obtained from Step 3) and 21 g (260 mol) of NaOAc in 52 mL of water and 160 mL of glacial acetic acid was stirred at reflux for 2 days, cooled and concentrated in vacuo. The residue was partitioned between chloroform and water. The combined extracts were dried (MgSO₄) and concentrated in vacuo. The residue was dissolved in 40 mL of chloroform and stirred with 8.0 g (28.7 mmol) of trityl chloride and 16 mL (0.115 mol) of TEA at room temperature overnight (16 h) and concentrated in vacuo. The residue was partitioned between chloroform and water. The combined extracts were dried (MgSO₄) and concentrated in vacuo. The residue was purified by chromatography (eluted with 2-propanol:hexane=1:10) to give 3.01 g (34%) of the trityl-protected biphenyl bicyclic imidazole: ¹ H NMR (CDCl₃) δ 0.76 (t, J=7.31 Hz, 3H), 1.18 (septet, J=7.4 Hz, 2H), 1.43-1.62 (m, 2H), 2.20-2.49 (m, 3H), 2.83-2.97 (m, 1H), 5.22-5.31 m (with d at 5.24, J=7.0 Hz), 2H!, 6.42 (dd, J=9.82, 3.05 Hz, 1H), 6.54 (d, J=8.2 Hz, 2H), 6.84 (d, J=7.81 Hz, 6H), 6.97 (d, J=6.07 Hz, 2H), 7.01 (s, 1H), 7.09-7.33 (m, 10H), 7.34-7.50 (m, 2H), 7.88 (dd, J=6.8, 2.16 Hz, 1H).

Step 5: Detritylation of the trityl tetrazole

A solution of 50 mg (0.078 mmol) of the trityl-protected biphenyl bicyclic imidazole (obtained from Step 4) was stirred with 0.5 mL of water and 2 mL of acetic acid at room temperature for 18 h. The solution was concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 25 mg (80%) of the title compound of Example 11 as an oil which solidified as a glass: mp: 146°-156° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.72 (t, J=7.27 Hz, 3H), 1.10-1.50 (m, 4H), 2.55-2.80 (m, 3H), 3.00-3.21 (m, 1H), 5.82 (d, J=7.66 Hz, 1H), 5.91-6.00 (m, 1H), 6.56 (dd, J=10.1, 3.06 Hz, 1H), 6.84 (d, J=8.19 Hz, 2H), 6.99 (d, J=8.35 Hz, 2H), 7.30-7.60 m (with s at 7.36), 5H!; HRMS. calcd. for M+H: 397.2141. Found: 397.2181.

EXAMPLE 12 ##STR31## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8(5H)-one

Step 1: Preparation of the bromohydrin intermediate

To a solution of 2.0 g (3.13 mmol) of biphenyl olefin imidazole (obtained from Step 4 of Example 11) in 2.2 mL (0.122 mmol) of water and 22 mL of DMSO at room temperature was added 587 mg (3.30 mmol) of NBS in one portion. The resulting orange solution was stirred at room temperature for 40 min, quenched with 100 mL of water and 12 mL of saturated Na₂ SO₃, extracted with two 100 mL portions of chloroform. The combined extracts were washed with two 60 mL portions of water, and the combined aqueous layer was extracted with 40 mL of chloroform. The combined extracts were washed with brine, dried (MgSO₄) and concentrated in vacuo to give a crude bromohydrin intermediate which was used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of the trityl tetrazolyl hydroxy imidazole

To the crude bromohydrin intermediate (3.13 mmol, obtained from Step 1) in 42 mL of degassed dry benzene was added 4.3 mL (14.7 mmol) of n-Bu₃ SnH and 456 mg (2.7 mmol) of AIBN in one portion and the resulting solution was stirred at reflux for 1 h. The mixture was concentrated in vacuo and partitioned between 20 mL of hexane and 80 mL of acetonitrile. The acetonitrile layer was washed with two fresh 20 mL portions of hexane, and the combined hexane layer was extracted with another 50 mL of acetonitrile. The combined acetonitrile extracts were concentrated in vacuo to give an isomeric mixture of both cis- and trans-hydroxy imidazole (relative to the biphenyl moiety). The ¹ H NMR spectrum of the crude mixture indicated a 1.8:1 ratio of the cis-hydroxy product to the trans-hydroxy product based on the integration areas of peaks at δ 5.09 (t) and 5.28 (d), respectively!. The crude mixture was used directly in subsequent Step 3 without further purification. In one experiment, the mixture was used to prepare the biphenyl trans-hydroxy imidazole (the title compound of Example 14).

Step 3: Preparation of the keto imidazole

A suspension of the crude product (2.72 mmol, obtained from Step 2) and 13 g of active MnO₂ in 15 mL of methylene chloride was stirred at room temperature for 17 h. The mixture was filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue was purified by chromatography to give 0.24 g (12%) of olefinic starting material (the trityl protected title compound of Example 11), and 1.01 g (57%) of trityl-protected keto imidazole as a solid: ¹ H NMR (CDCl₃) δ 0.72 (t, J=7.25 Hz, 3H), 1.13 (septet, J=7.26 Hz, 2H), 1.40-1.65 (m, 2H), 1.95-2.22 (m, 3H), 2.25-2.42 (m, 2H), 2.45-2.60 (m, 1H), 5.36 (br d, J=3.22 Hz, 1H), 6.54 (d, J=8.06 Hz, 2H), 6.83 (d, J=7.66 Hz, 6H), 7.08 (d, J=8.06 Hz, 2H), 7.13-7.35 (m, 10H), 7.42 (quintet, J=3.63 Hz, 2H), 7.86 (s, 1H), 7.92 (dd, J=6.85, 1.61 Hz, 1H).

Step 4: Detritylation of trityl tetrazolyl imidazole

A solution of 86 mg (0.131 mmol) of trityl-protected keto imidazole (obtained from Step 3) in 1.0 mL of water and 5.0 mL of acetic acid was stirred at room temperature for 20 h, and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 54 mg (quantitative) of the title compound of Example 12 as a solid: mp 128°-144° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.82 (t, J=7.25 Hz, 3H), 1.15-1.35 (m, 2H), 1.35-1.65 (m, 2H), 2.3-2.8 (m, 6H), 5.84 (d, J=3.23 Hz, 1H), 6.88 (d, J=8.46 Hz, 2H), 7.13 (d,J=8.06 Hz, 2H), 7.49-7.60 (m, 2H), 7.60-7.70 (m, 2H), 7.80 (s, 1H); HRMS. calcd for M+H: 413.2090. Found: 413.2016.

EXAMPLE 13 ##STR32## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-ol

Step 1: Preparation of biphenyl cis-hydroxy imidazole

To a solution of 298 mg (0.456 mmol) of ketone (obtained from Step 3 of Example 12) in 0.5 mL of methanol and 2.0 mL of THF at 0° C. was added in small portions 34 mg (0.899 mmol) of NaBH₄. The resulting solution was stirred at 0° C. and slowly warmed to room temperature for 17 h. The reaction was quenched with aqueous NH₄ Cl, extracted with methylene chloride, dried (MgSO₄) and concentrated in vacuo. The residue was chromatography to give 273 mg (91%) of the biphenyl cis-hydroxy imidazole (relative to the biphenyl moiety) as a solid: ¹ H NMR (CDCl₃) δ 0.68 (t, J=7.46 Hz, 3H), 1.07 (septet, J=7.38 Hz, 2H), 1.25-1.64 (m, 3H), 1.68-1.82 (m, 2H), 1.82-1.96 (m, 2H), 1.96-2.15 m (with t at 2.10, J=8.4 Hz,), 3H!, 4.84 (dd, J=8.7, 5.57 Hz, 1H), 5.03 (t, J=5.06 Hz, 1H), 6.63 (d, J=8.27 Hz, 2H), 6.89 (d, J=7.08 Hz, 6H), 6.98-7.08 m (with s at 7.03 and d at 7.03, J=8.27 Hz), 3H!, 7.15-7.32 (m, 10H), 7.32-7.45 (m, 2H), 7.85 (dd, J=6.85, 2.17 Hz, 1H).

Step 2: Detritylation of trityl tetrazolyl imidazole

A solution of 170 mg (0.259 mmol) of trityl-protected biphenyl hydroxy imidazole (obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid was stirred at room temperature for 16 h and concentrated in vacuo. The residue was dissolved in a minimum amount of methanol, diluted with methylene chloride, then triturated with ether to give 92 mg (86%) of the title compound of Example 13 as a solid: mp 175.5°-180° C.; ¹ H NMR (CD₃ OD) δ 0.80 (t, J=7.26 Hz, 3H), 1.15-1.28 (m, 2H), 1.28-1.43 (m, 1H), 1.43-1.60 (m, 1H), 1.69-1.86 (m, 1H), 1.92-2.05 (m, 1H), 2.13-2.28 (m 1H), 2.28-2.55 (m, 3H), 4.81-4.95 (m, 1H), 5.57 (t, J=4.80 Hz, 1H), 6.90 (d, J=8.46 Hz, 2H), 7.14 (d, J=8.06 Hz, 2H), 7.36 (s, 1H), 7.40-7.62 (m, 4H); HRMS. calcd for M+Li: 421.2328. Found: 421.2306.

EXAMPLE 14 ##STR33## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-trans-8-ol

Step 1: Preparation of biphenyl trans-hydroxy imidazole

A suspension of the crude biphenyl hydroxy imidazole (1.307 mmol, obtained from Step 2 of Example 12) and 3.0 g of active MnO₂ in 5.0 mL of methylene chloride was stirred at room temperature. The reaction was stopped before its completion (in this particular experiment, the reaction time was 14 h). The mixture was filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue was purified by chromatography to give 190 mg of olefinic starting material (23% from Step 1 of Example 12), 341 mg of trityl-protected ketone (40% from Step 1 of Example 12), and 74 mg of the trityl protected biphenyl trans-hydroxy imidazole (9% from Step 1 of Example 12) as a solid: ¹ H NMR (CDCl₃) δ 0.76 (t, J=7.25 Hz, 3H), 1.16 (septet, J=7.25 Hz, 2H), 1.23-1.62 (m, 4H), 1.68 (br d, J=12.09 Hz, 1H), 2.07-2.34 (m, 2H), 2.56-2.73 (m, 1H), 2.73-2.95 (br s, 1H). 4.94 (br s, 1H), 5.26 (br d, J=3.62 Hz, 1H), 6.47 (d, J=8.06 Hz, 2H), 6.90 (d, J=7.25 Hz, 6H), 7.05 (s, 1H), 7.07 (d, J=8.06 Hz, 2H), 7.17-7.38 (m, 10H), 7.40-7.55 (m, 2H), 7.93 (dd, J=7.25, 2.02 Hz, 1H).

Alternatively, the biphenyl trans-hydroxy imidazole can be prepared using the Mitsunobu reaction conditions. To a solution of diethyl azodicarboxylate (2.0 mmol) and 3-nitrobenzoic acid (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of the biphenyl hydroxy imidazole (2.0 mmol, obtained from Step 1 of Example 13), and triphenylphosphine (2.0 mmol) in 1.0 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate, and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo to give the biphenyl imidazolyl nitrobenzoate. The crude benzoate is hydrolyzed with LiOH in aqueous THF at room temperture and purified to give the biphenyl trans-hydroxy imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of 52 mg (0.079 mmol) of biphenyl trans-hydroxy imidazole (obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid was stirred at room temperature for 17 h and concentrated in vacuo. The residue was dissolved in a minimum amount of methanol, diluted with methylene chloride, then triturated with ether to give 23 mg (70%) of the title compound of Example 14 as a solid: mp 185.2°-188.0° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.82 (t, J=7.26 Hz, 3H), 1.15-1.62 (m, 4H), 1.72-1.87 (m, 1H), 1.90-2.10 (m, 2H), 2.35-2.60 (m, 2H), 2.63-2.80 (m, 1H), 5.01 (t, J=3.9 Hz, 1H), 5.65 (br t, J=5.1 Hz, 1H), 6.81 (d, J=8.40 Hz, 2H), 7.13 (d, J=8.4 Hz, 2H), 7.39 (s, 1H), 7.42-7.65 (m, 4H); MS(FAB) m/e (relative intensity): 415(100, M+H), 372(20), 359(18); HRMS. calcd for M+Li: 421.2328. Found: 421.2373.

EXAMPLE 15 ##STR34## 1,1-Dimethylethyl 3-butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo1,5-a!pyridin-8(5H)-ylidene!acetate

Step 1: Preparation of tert-butyl ester

To a suspension of 64 mg (2.63 mmol) of magnesium in 3.0 mL of THF at 55° C. was added two 10 μL portions of 1,2-dibromoethane, 5 min apart. The resulting mixture was stirred at 45° C. for 10 min, followed by dropwise addition of a solution of 200 mg (0.306 mmol) of trityl-protected keto imidazole (obtained from Step 3 of Example 12) and 242 μL (1.50 mmol) of tert-butyl bromoacetate in 2.0 mL of THF at 55° C. over a 1 h period. The resulting solution was stirred for an additional 20 min, cooled and quenched with aqueous NH₄ Cl. The mixture was extracted with ether, dried (MgSO₄) and concentrated in vacuo. The crude mixture was used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of unsaturated butyl ester

To a solution of the crude alcohol (0.306 mmol) (obtained from Step 1) and 200 μL (2.47 mmol) of pyridine in 2 mL of methylene chloride at 0° C. was added dropwise 80 μL (1.1 mmol) of thionyl chloride. The resulting dark brown solution was stirred at 0° C. for 1 h, diluted with water and extracted with methylene chloride. TLC analysis indicated that some product was detritylated. The methylene chloride solution was treated with 100 mg of trityl chloride and 200 μL of TEA, stirred at room temperature for 16 h, and concentrated in vacuo. The residue was purified by chromatography to give 164 mg (71%) of the biphenyl imidazolyl unsaturated ester as an oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.77 (t, J=7.26 Hz, 3H), 1.17 (septet, J=7.25 Hz, 2H), 1.40-1.70 m (with s at 1.47), 11H!, 1.96-2.12 (m, 1H), 2.12-2.32 (m, 2H), 2.32-2.52 (m, 2H), 3.50 (d, J=15.7 Hz, 1H), 5.28-5.40 (br s, 1H), 6.23 (s, 1H), 6.60 (d, J=8.47 Hz, 2H), 6.90 (d, J=7.25 Hz, 6H), 7.14 (d, J=8.06 Hz, 2H), 7.20-7.40 (m, 10H), 7.42-7.56 (m, 2H), 7.60 (s, 1H), 7.97 (dd, J=7.25, 2.01 Hz, 1H).

Step 3: Detritylation of trityl tetrazolyl imidazole

A solution of 100 mg (0.133 mmol) of trityl-protected imidazolyl butyl ester (obtained from Step 2) in 1.0 mL of water and 5.0 mL of acetic acid was stirred at room temperature for 20 h and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1 to give 66 mg (97%) of the title compound of Example 15 as a solid: mp 205-212° C. (decomposed); ¹ H NMR (CD₃ OD) δ 1.09 (t, J=7.31 Hz, 3H), 1.43-1.65 (m, 2H), 1.65-1.95 m (with s at 1.76), 11H!, 2.45-2.65 (m, 3H), 2.68-2.95 (m, 2H), 3.73-3.92 (m, 1H), 5.95-6.02 (br s, 1H), 6.61 (s, 1H), 7.12 (d, J=8.09 Hz, 2H), 7.40 (d, J=8.28 Hz, 2H), 7.79 (t, J=7.58 Hz, 2H), 7.89 (t, J=7.81 Hz, 2H), 7.97 (s, 1H), 8.17 (s, 1H); HRMS. calcd for M+H: 511.2821. Found: 511.2793.

EXAMPLE 16 ##STR35## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5- a!pyridin-8(5H)-ylidene!acetic acid

To a solution of 32 mg (0.0627 mmol) of tert-butyl ester (the title compound of Example 15) in 2 mL of CDCl₃ at room temperature was added 0.5 mL of TFA, and the progress of the reaction was monitored by ¹ H NMR. The resulting yellow solution was stirred at room temperature for 1 h and concentrated in vacuo. The crude product was dissolved in a minimum amount of methanol, diluted with methylene chloride, then triturated with ether and hexane at 5° C. to give 27 mg (96%) of the title compound of Example 16 as a solid: mp 154.0°-155.5° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.84 (t, J=7.5 Hz, 3H), 1.2-1.45 (m, 2H), 1.45-1.63 (m, 2H), 2.25-2.55 (m, 3H), 2.60-2.9 (m, 2H), 3.52-3.7 (m, 1H), 5.95 (br s, 1H), 6.59 (s, 1H), 6.99 (d, J=7.5 Hz, 2H), 7.19 (d, J=7.7 Hz, 2H), 7.50-7.62 (m, 2H), 7.67 (d, J=7.2 Hz, 2H), 8.16 (s, 1H); HRMS. calcd for M+H: 455.2195. Found: 455.2195.

EXAMPLE 17 ##STR36## 1,1-Dimethylethyl 3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-acetate

Step 1: Preparation of deconjugated ester

To a solution of 178 mg (0.237 mmol) of conjugated butyl ester (obtained from Step 2 of Example 15) in 4 mL of THF at 0° C. was added 310 μL of 1.5M (0.467 mmol) LDA over a 2 min period, and the resulting solution was stirred at 0° C. for 10 min. The mixture was cooled to -78° C., stirred cold for 5 min, and quenched at -78° C. with dropwise addition of 100 μL of acetic acid in 1 mL of hexane. The mixture was stirred cold for 15 min, then warmed to room temperature and treated with aqueous NaHCO₃. The mixture was extracted with three 5 mL portions of methylene chloride. The combined extracts were washed with water, dried (MgSO₄) and concentrated in vacuo to give a crude biphenyl imidazolyl deconjugated ester. No starting material could be detected by the ¹ H NMR spectrum. The crude product was purified by chromatography to give 145 mg (81%) of the biphenyl imidazolyl deconjugated ester as a solid: ¹ H NMR (CDCl₃) δ 0.74 (t, J=7.23 Hz, 3H), 1.16 (septet, 7.39 Hz, 2H), 1.41 (s, 9H), 1.42-1.60 (m, 2H), 2.20 (dd, J=17.05, 6.61 Hz, 1H), 2.23-2.50 (m, 2H), 2.93 (ddd, J=17.3, 7.65, 1.74 Hz, 1H), 3.20 (s, 2H), 5.12-5.25 m (with d at 5.17, J=7.66 Hz), 2H!, 6.58 (d, J=8.0 Hz, 2H), 6.82 (d, J=7.84 Hz, 6H), 6.99 (d, J=8.27 Hz, 2H), 7.05 (s, 1H), 7.15-7.35 (m, 10H), 7.35-7.50 (m, 2H), 7.88 (dd, J=6.69, 2.24 Hz, 1H).

Step 2: Detritylation of trityl tetrazolyl imidazole

A solution of 124 mg (0.165 mmol) of trityl biphenyl imidazole (obtained from Step 1) in 1 mL of water and 3 mL of acetic acid was stirred at room temperature for 2 days, and concentrated in vacuo. The residue was worked up as described in Step 5 of Example 1. The crude product was recrystallized from methylene chloride-ether to give 78 mg (93%) of the title compound of Example 17 as a solid: mp 221°-223° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.83 (t, J=7.25 Hz, 3H), 1.15-1.60 m (with s at 1.44), 13H), 2.72-2.97 (m, 3H), 3.19-3.3 (m, 1H), 3,40 (d, J=16.5 Hz, 1H), 3.49 (d, J=15.71 Hz, 1H), 5.88-6.0 m (with d at 5.92, J=7.26 Hz), 2H!, 7.11 (s, 4H), 7.51 (d, J=7.65 Hz, 1H), 7.55-7.62 (m, 2H), 7.62-7.73 (m, 2H); HRMS. calcd for M+H: 511.2821. Found: 511.2847.

EXAMPLE 18 ##STR37## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-acetic acid

To a solution of 20 mg (0.039 mmol) of biphenyl imidazolyl tert-butyl ester (the title compound of Example 17) in 0.5 mL of chloroform was added 0.25 mL of TFA, and the progress of the reaction was monitored by ¹ H NMR. The resulting solution was stirred at room temperature for 75 min. The mixture was quenched with methanol and concentrated in vacuo. The residue was dissolved in a minimum amount of methanol and triturated with dropwise addition of methylene chloride-ether-hexane to give 15 mg (84%) of the title compound of Example 18 as a solid: mp 148°-171° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.83 (t, J=7.25 Hz, 3H), 1.10-1.60 (m, 4H), 2.68-2.95 (m, 3H), 3.13-3.35 (m, 1H), 3.48-3.60 (m, 2H), 5.80-6.0 m (with d at 5.87, J=7.66 Hz), 2H!, 7.10 (br s, 4H), 7.40-7.75 (m, 5H); HRMS. calcd for M+H: 455.2195. Found: 455.2215.

EXAMPLE 19 ##STR38## 1,1-Dimethylethyl 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-acetate

A suspension of 30 mg (0.059 mmol) of the imidazolyl unsaturated butyl ester (the title compound of Example 17) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol was stirred at room temperature under an atmosphere of hydrogen gas for 4 h. The mixture was filtered through a pad of celite and concentrated in vacuo. The residue was recrystallized from methanol, ether and hexane to give 28 mg (93%) of the title compound as a solid: mp 194°-203° C. (decomposed); ¹ H NMR (CD₃ OD) δ 0.84 (t, J=7.25 Hz, 3H), 1.15-1.75 (m, 15H), 1.82-2.00 (m, 1H), 2.20 (br d, J=14.1 Hz, 1H), 2.38-2.59 (m, 2H), 2.59-2.78 m (with dd at 2.68, J=16.5, 6.85 Hz), 2H!, 2.86 (br dd, J=16.1, 4.84 Hz, 1H), 5.80 (br d, J=4.03 Hz, 1H), 6.95 (d, J=7.65 Hz, 2H), 7.16 (d, J=7.66 Hz, 2H), 7.40 (s, 1H), 7.46-7.63 (m, 2H), 7.63-7.75 (m, 2H); HRMS. calcd for M+H: 513.2978. Found: 513.2992.

EXAMPLE 20 ##STR39## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-cis-8-acetic acid

To a solution of 17 mg (0.0332 mmol) of biphenyl imidazolyl tert-butyl ester (the title compound of Example 19) in 0.4 mL of CDCl₃ was added 0.2 mL of TFA, and the progress of the reaction was monitored by ¹ H NMR. The resulting solution was allowed to stand at room temperature for 1.5 h. The reaction mixture was diluted with methanol and concentrated. The residue was recrystallized from methanol, methylene chloride and ether to give 13 mg (87%) of the title compound of Example 20 as a solid: mp 119.5°-122° C.; ¹ H NMR (CD₃ OD) δ 0.84 (t, J=7.25 Hz, 3H), 1.13-1.73 (m, 6H), 1.87-2.00 (m, 1H), 2.20 (br d, J=14.1 Hz, 1H), 2.40-2.57 (m, 2H), 2.57-2.70 (m, 1H), 2.76 (dd, J=16.5, 6.45 Hz, 1H), 2.90 (dd, J=16.51, 5.23 Hz, 1H), 5.78 (d, J=4.43 Hz, 1H), 6.96 (d, J=8.05 Hz, 2H), 7.16 (d, J=8.46 Hz, 2H), 7.42 (s, 1H), 7.48-7.62 (m, 2H), 7.62-7.72 (m, 2H); HRMS. calcd for M+H: 457.2352. Found: 457.2371.

EXAMPLE 21 ##STR40## 1,3-Dibutyl-5,6-dihydro-N-hydroxy-5- 2'-(1H-tetrazol-5-yl) 1.1'-biphenyl!-4-yl!imidazol 1,5-a!pyridin-8(7H)-imine

A mixture of 44 mg (0.094 mmol) of biphenyl keto imidazole (the title compound of Example 5), 20 mg (0.29 mmol) of N-hydroxyamine (hydrochloride salt) and 30 mg of NaOAc in 2 mL of methanol was stirred at 60° C. for 16 h. The mixture was diluted with chloroform and filtered. The solid was washed with methanol. The filtrate was concentrated in vacuo and recrystallized from methanol and chloroform at 5° C. to give 33 mg of the oxime as a solid: ¹ H NMR (CD₃ OD) δ 0.68 (t, J=7.31 Hz, 3H), 0.82 (t, J=7.30 Hz, 3H), 1.11 (quintet, J=7.65 Hz, 2H), 1.19-1.45 (m, 4H), 1.53 (quintet, J=7.66 Hz, 2H), 1.85-2.07 (m, 1H), 2.12-2.35 (br s, 2H), 2.56 (t, J=7.85 Hz, 2H), 2.83 (septet, J=8.28 Hz, 2H), 2.95 (d, J=17.50 Hz, 1H), 5.68 (s, 1H), 6.70 (d, J=8.00 Hz, 2H), 6.99 (d, J=8.20 Hz, 2H), 7.25-7.55 m (with t at 7.33, J=7.38 Hz), 5H!; ¹³ C NMR (CD₃ OD) δ 12.22, 12.59, 15.93, 21.51, 21.85, 24.05, 25.34, 27.70, 28.42, 30.15, 55.53, 121.60, 124.73,127.01, 127.07, 127.44, 127.67, 129.24, 129.40, 129.74, 130.19, 132.79, 136.43, 140.60, 140.80, 145.59, 145.86, 159.37; MS(FAB) m/e (relative intensity): 484 (100, M+H), 456 (60), 427 (30); HRMS. calcd for M+H: 484.2825. Found: 484.2837.

EXAMPLE 22 ##STR41## 1- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridin-8-yl!phthalimide

Step 1: Preparation of biphenyl phthalimidyl imidazole

To a solution of the biphenyl hydroxy imidazole (2.0 mmol, obtained from Step 1 of Example 13 or 14), phthalimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected phthalimidyl imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl phthalimidyl imidazole (2.0 mmol, obtained from Step 1) in 2 mL of water and 10 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 5 of Example 1 and purified give the title compound of Example 22.

EXAMPLE 23 ##STR42## 3-Butyl-5,6,7,8-tetrahydro-8-amino-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,5-a!pyridine

A solution of phthalimidyl imidazole (0.6 mmol, the title compound of Example 22) and 3 μL (1.5 mmol) of hydrazine in 1.0 mL of ethanol is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo, and purified to give the title compound of Example 23.

Alternatively, the title compound of Example 23 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, can be prepared from biphenyl ketone imidazole, the title compound of Example 12, according to the procedure described in Example 21) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 23.

EXAMPLE 24 ##STR43## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-cis-8-phenylmethoxy-imidazo 1,5-a!pyridine

Step 1: Preparation of biphenyl phenylmethoxyimidazole

To a solution of 203 mg (0.318 mmol) of biphenyl bicyclic imidazole (trityl protected Example 11) and 200 μL (1.9 mmol) of benzyl alcohol in 0.5 mL of anhydrous chloroform was added 57 mg (0.32 mmol) of NBS in one portion. The resulting orange-red solution was stirred at room temperature for 2 hours, and the reaction mixture was washed with aqueous sodium bisulfite, water,and brine. The combined extracts were dried (MgSO₄) and concentrated in vacuo. The residue was used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of trityl tetrazolyl phenylmethoxy imidazole

To the crude bromohydrin (0.318 mmol, obtained from Step 1) in 3 mL of degassed dry benzene was added 150 μL (0.52 mmol) of n-Bu₃ SnH and 30 mg (0.18 mmol) of AIBN in one portion and the resulting solution was stirred at reflux for 2 h. The mixture was concentrated in vacuo and partitioned between 5 mL of hexane and 5 mL of acetonitrile. The acetonitrile layer was washed with two fresh 2-mL portions of hexane, and the combined hexane layer was extracted with another 5 mL of acetonitrile. The combined acetonitrile solution was concentrated in vacuo and purified by chromatography to give 131 mg (55%) of the biphenyl phenylmethoxy imidazole as a colorless oil: ¹ H NMR (CDCl₃) δ 0.73 (t, J=7.26 Hz, 3H), 1.12 (septet, J=7.66 Hz, 2H), 1.16-1.60 (m, 3H), 1.70-2.20 (m, 6H), 4.61 (d, J=11.7 Hz, 1H), 4.66 (t, J=5.24 Hz, 1H), 4.72 (d, J=11.7 Hz, 1H), 4.97 (t, J=7.50 Hz, 1H), 6.81 (d, J=8.1 Hz, 2H), 6.91 (d, J=7.9 Hz, 6H), 7.10 (d, J=8.46 Hz, 2H), 7.15-7.41 (m, 15H), 7.4-7.53 (m, 2H), 7.92 (d, J=3.8 Hz, 1H).

Step 3: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl phenylmethoxy imidazole (0.176 mmol, obtained from Step 2) in 0.4 mL of water and 2 mL of acetic acid was stirred at room temperature until the reaction was complete. The mixture was concentrated in vacuo, stirred in 2 mL of aqueous NaHCO₃ and washed with three 2-mL portions of ether and the ether extracts were discarded. The aqueous residue was acidified with 3N HCl to pH 4 and extracted with methylene chloride. The combined methylene chloride extracts were dried (MgSO₄) and concentrated in vacuo. The residue was purified by chromatography to give 71 mg (80% ) of the biphenyl phenylmethoxy imidazole, the title compound of Example 1, as an oil which solidified as a glass: ¹ H NMR (CDCl₃) δ 0.78 (t, J=7.05 Hz, 3H), 1.15 (septet, J=7.25 Hz, 2H), 1.3-1.6 (m, 2H), 1.75-1,95 (m, 2H), 2.0-2.12 (m, 2H), 2.17 (q, J=5.64 Hz, 2H), 4.45-4.63 m (with q_(AB) at 4.56, J=12 Hz), 3H!, 5.07 (t, J=5.63 Hz, 1H), 6.24 (br s, 1H), 6.73 (d, J=7.85 Hz, 2H), 6.98 (d, J=8.06 Hz, 2H), 7.25-7.45 (m, 6H), 7.47-7.60 (m, 2H), 7.78 (d, J=6.45 Hz, 1H).

The following examples, 25-1450, located in Tables I-XXIV, are further conformationally restricted angiotensin II antagonists embraced by Formula II above.

                  TABLE I                                                          ______________________________________                                          ##STR44##                                                                     EX. # R.sup.1       R.sup.2  R.sup.3                                           ______________________________________                                         25    H             C.sub.3 H.sub.7 (n)                                                                     H                                                 26    H             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   27    H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       28    H             C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        29    H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               30    H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               31    H             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     32    H             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3                                  1                                                 33    H             C.sub.3 H.sub.7 (n)                                                                     phenyl                                            34    H             C.sub.3 H.sub.7 (n)                                                                     benzyl                                            35    H             C.sub.3 H.sub.7 (n)                                                                     phenylethyl                                       36    H             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   37    H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       38    H             C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        39    H             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     40    H             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3                                  2                                                 41    H             C.sub.4 H.sub.9 (n)                                                                     phenyl                                            42    H             C.sub.4 H.sub.9 (n)                                                                     benzyl                                            43    H             C.sub.4 H.sub.9 (n)                                                                     phenylethyl                                       44    Cl            C.sub.3 H.sub.7 (n)                                                                     H                                                 45    Cl            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   46    Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       47    Cl            C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        48    Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               49    Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               50    Cl            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     51    Cl            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3                                  1                                                 52    Cl            C.sub.4 H.sub.9 (n)                                                                     H                                                 53    Cl            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   54    Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       55    Cl            C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        56    Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               57    Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               58    Cl            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     59    Cl            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3                                  .                                                 60    ethyl         C.sub.3 H.sub.7 (n)                                                                     H                                                 61    ethyl         C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   62    ethyl         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       63    ethyl         C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        64    ethyl         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               65    ethyl         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               66    ethyl         C.sub.4 H.sub.9 (n)                                                                     H                                                 67    ethyl         C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   68    ethyl         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       69    ethyl         C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        70    ethyl         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               71    ethyl         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               72    n-butyl       C.sub.3 H.sub.7 (n)                                                                     H                                                 73    n-butyl       C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   74    n-butyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       75    n-butyl       C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        76    n-butyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               77    n-butyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               78    n-butyl       C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   79    n-butyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       80    n-butyl       C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        81    n-butyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               82    n-butyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               83    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H                                                 84    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   85    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       86    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        87    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               88    (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               89    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H                                                 90    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   91    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       92    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        93    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               94    (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               95    (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H                                                 96    (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   97    (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       98    (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        99    (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               100   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               101   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H                                                 102   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   103   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       104   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        105   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               106   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               ______________________________________                                    

                  TABLE II                                                         ______________________________________                                          ##STR45##                                                                     EX. #   R.sup.4        R.sup.5  R.sup.6                                        ______________________________________                                         107     H              C.sub.3 H.sub.7 (n)                                                                     O                                              108     H              C.sub.3 H.sub.7 (n)                                                                     S                                              109     H              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   110     H              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   111     H              C.sub.3 H.sub.7 (n)                                                                     NOH                                            112     H              C.sub.4 H.sub.9 (n)                                                                     S                                              113     H              C.sub.4 H.sub.9 (n)                                                                     NOH                                            114     Cl             C.sub.3 H.sub.7 (n)                                                                     O                                              115     Cl             C.sub.3 H.sub.7 (n)                                                                     S                                              116     Cl             C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   117     Cl             C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   118     Cl             C.sub.3 H.sub.7 (n)                                                                     NOH                                            119     Cl             C.sub.4 H.sub.9 (n)                                                                     O                                              120     Cl             C.sub.4 H.sub.9 (n)                                                                     S                                              121     Cl             C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   122     Cl             C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   123     Cl             C.sub.4 H.sub.9 (n)                                                                     NOH                                            124     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     O                                              125     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     S                                              126     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   127     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   128     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     NOH                                            129     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     O                                              130     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     S                                              131     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   132     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   133     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     NOH                                            134     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     O                                              135     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     S                                              136     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   137     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   138     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     S                                              139     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   140     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     NOH                                            141     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     O                                              142     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     S                                              143     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   144     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     NOH                                            145     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     O                                              146     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     S                                              147     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   148     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     NOH                                            149     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     O                                              150     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     S                                              151     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   152     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     NOH                                            153     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     O                                              154     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     S                                              155     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   156     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     NOH                                            ______________________________________                                    

                  TABLE III                                                        ______________________________________                                          ##STR46##                                                                     EX. #    R.sup.7         R.sup.8   R.sup.9                                     ______________________________________                                         157      H               C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             158      H               C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         159      H               C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             160      H               C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         161      Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             162      Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         163      Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             164      Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         165      C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             166      C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         167      C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             168      C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         169      C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             170      C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             171      (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             172      (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             173      (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             174      (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             ______________________________________                                    

                  TABLE IV                                                         ______________________________________                                          ##STR47##                                                                     EX. #   R.sup.10       R.sup.11 R.sup.12                                       ______________________________________                                         175     H              C.sub.3 H.sub.7 (n)                                                                     H                                              176     H              C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       177     H              C.sub.3 H.sub.7 (n)                                                                     OH                                             178     H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    179     H              C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     180     H              C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     181     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                182     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            183     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                184     H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       185     H              C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                186     H              C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      187     H              C.sub.4 H.sub.9 (n)                                                                     H                                              188     H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    189     H              C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     190     H              C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     191     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                192     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            193     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                194     H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       195     H              C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                196     Cl             C.sub.3 H.sub.7 (n)                                                                     H                                              197     Cl             C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       198     Cl             C.sub.3 H.sub.7 (n)                                                                     OH                                             199     Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    200     Cl             C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     201     Cl             C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     202     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                203     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            204     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                205     Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       206     Cl             C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                207     Cl             C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      208     Cl             C.sub.4 H.sub.9 (n)                                                                     H                                              209     Cl             C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       210     Cl             C.sub.4 H.sub.9 (n)                                                                     OH                                             211     Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    212     Cl             C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     213     Cl             C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     214     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                215     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            216     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                217     Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       218     Cl             C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                219     Cl             C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      220     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              221     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       222     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             223     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    224     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     225     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     226     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                227     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              228     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       229     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             230     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    231     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     232     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     233     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                234     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     H                                              235     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       236     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     OH                                             237     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    238     C.sub.4 H.sub.9                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     239     C.sub.4 H.sub.9                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     240     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                241     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       242     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       243     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    244     C.sub.4 H.sub.9                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     245     C.sub.4 H.sub.9                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     246     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                247     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              248     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       249     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             250     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    251     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     252     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     253     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                254     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              255     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       256     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             257     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    258     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     259     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     260     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                261     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     H                                              262     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       263     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     OH                                             264     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    265     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                     266     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     267     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                268     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     H                                              269     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       270     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     OH                                             271     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    272     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                     273     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 C(CH.sub.3).sub.3                     274     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE V                                                          ______________________________________                                          ##STR48##                                                                     EX. #                                                                               R.sup.13       R.sup.14                                                                               R.sup.15                                                                               R.sup.16                                   ______________________________________                                         275  H              C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   276  H              C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   277  H              C.sub.3 H.sub.7 (n)                                                                    CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                   278  H              C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   279  H              C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   280  H              C.sub.4 H.sub.9 (n)                                                                    CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                   281  Cl             C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   282  Cl             C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   283  Cl             C.sub.3 H.sub.7 (n)                                                                    CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                   284  Cl             C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   285  Cl             C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   286  Cl             C.sub.4 H.sub.9 (n)                                                                    CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                   287  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   288  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   289  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   290  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   291  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   292  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   293  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   294  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   295  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   296  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   297  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   298  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   299  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.3                                   300  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   301  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.3                                   302  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.3                                   303  H              C.sub.3 H.sub.7 (n)                                                                    H       C.sub.2 H.sub.5                            304  H              C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            305  H              C.sub.3 H.sub.7 (n)                                                                    C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                            306  H              C.sub.4 H.sub.9 (n)                                                                    H       C.sub.2 H.sub.5                            307  H              C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            308  H              C.sub.4 H.sub.9 (n)                                                                    C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                            309  Cl             C.sub.3 H.sub.7 (n)                                                                    H       C.sub.2 H.sub.5                            310  Cl             C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            311  Cl             C.sub.3 H.sub.7 (n)                                                                    C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                            312  Cl             C.sub.4 H.sub.9 (n)                                                                    H       C.sub.2 H.sub.5                            313  Cl             C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            314  Cl             C.sub.4 H.sub.9 (n)                                                                    C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                            315  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    H       C.sub.2 H.sub.5                            316  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            317  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    H       C.sub.2 H.sub.5                            318  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.2 H.sub.5                            319  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                    H       C.sub.2 H.sub.5                            320  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                    H       C.sub.2 H.sub.5                            321  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                    H       C.sub.2 H.sub.5                            322  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                    H       C.sub.2 H.sub.5                            323  H              C.sub.3 H.sub.7 (n)                                                                    H       C.sub.6 H.sub.5                            324  H              C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            325  H              C.sub.4 H.sub.9 (n)                                                                    H       C.sub.6 H.sub.5                            326  H              C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            327  Cl             C.sub.3 H.sub.7 (n)                                                                    H       C.sub.6 H.sub.5                            328  Cl             C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            329  Cl             C.sub.4 H.sub.9 (n)                                                                    H       C.sub.6 H.sub.5                            330  Cl             C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            331  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    H       C.sub.6 H.sub.5                            332  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            333  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    H       C.sub.6 H.sub.5                            334  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            335  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                    H       C.sub.6 H.sub.5                            336  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            337  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    H       C.sub.6 H.sub.5                            338  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               C.sub.6 H.sub.5                            339  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.2 CH.sub.2 CO.sub.2 H               340  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H               341  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.2 CH.sub.2 CO.sub.2 H               342  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H               343  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.2 CH.sub.2 CO.sub.2 H               344  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H               345  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                    H       CH.sub.2 CH.sub.2 CO.sub.2 H               346  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                    CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H               347  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                    H       CH.sub.2 CH.sub.2 CO.sub.2 H               348  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                    CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H               ______________________________________                                    

                  TABLE VI                                                         ______________________________________                                          ##STR49##                                                                     EX. #     R.sup.17     R.sup.18   R.sup.19, R.sup.20                           ______________________________________                                         349       H            C.sub.3 H.sub.7 (n)                                                                       O                                            350       H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          351       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   352       H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            353       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                354       H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 355       H            C.sub.4 H.sub.9 (n)                                                                       O                                            356       H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          357       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   358       H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            359       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                360       H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 361       Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            362       Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          363       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   364       Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            365       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                366       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 367       Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            368       Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          369       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   370       Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            371       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                372       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 373       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            374       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          375       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   376       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            377       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                378       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 379       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            380       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          381       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   382       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            383       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                384       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 385       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            386       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          387       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   388       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                389       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 390       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          391       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   392       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                393       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 394       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            395       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          396       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   397       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            398       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                399       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 400       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            401       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          402       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   403       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            404       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                405       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 406       H            C.sub.3 H.sub.7 (n)                                                                       O                                            407       H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          408       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   409       H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            410       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                411       H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 412       H            C.sub.4 H.sub.9 (n)                                                                       O                                            413       H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          414       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   415       H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            416       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                417       H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 418       Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            419       Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          420       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   421       Cl           C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            422       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                423       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 424       Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            425       Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          426       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   427       Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            428       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                429       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 430       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            431       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          432       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   433       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            434       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                435       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 436       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            437       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          438       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   439       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            440       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                441       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 442       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            443       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          444       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   445       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                446       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 447       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            448       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          449       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   450       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                451       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 452       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            453       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          454       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   455       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            456       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                457       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 458       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            459       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          460       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   461       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            462       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                463       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE VIII                                                       ______________________________________                                          ##STR50##                                                                     EX. #  R.sup.25       R.sup.26 R.sup.27                                        ______________________________________                                         464    H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        465    H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                             466    H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                    467    H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               468    H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 C.sub.6 H.sub.5)CH.sub.2             469    H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            470    H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                             471    H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                    472    H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               473    H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                     474    H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            475    Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        476    Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                             477    Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                    478    Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               479    Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                     480    Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            481    Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                        482    Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                             483    Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                    484    Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               485    Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                     486    Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            487    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        488    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                             489    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5                     490    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               491    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                     492    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            493    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                        494    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                             495    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                    496    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               497    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                     498    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2            499    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        500    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               501    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                        502    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               503    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        504    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               505    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                        506    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               507    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                        508    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                               509    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                        510    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                               ______________________________________                                    

                  TABLE IX                                                         ______________________________________                                          ##STR51##                                                                     EX. #   R.sup.28    R.sup.29 R.sup.30                                          ______________________________________                                         511     H           C.sub.3 H.sub.7 (n)                                                                     H                                                 512     H           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   513     H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       514     H           C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        515     H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               516     H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               517     H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     518     H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     519     H           C.sub.3 H.sub.7 (n)                                                                     phenyl                                            520     H           C.sub.3 H.sub.7 (n)                                                                     benzyl                                            521     H           C.sub.3 H.sub.7 (n)                                                                     phenylethyl                                       522     H           C.sub.4 H.sub.9 (n)                                                                     H                                                 523     H           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.9                                   524     H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       525     H           C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        526     H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               527     H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               528     H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     529     H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     530     H           C.sub.4 H.sub.9 (n)                                                                     phenyl                                            531     H           C.sub.4 H.sub.9 (n)                                                                     benzyl                                            532     H           C.sub.4 H.sub.9 (n)                                                                     phenylethyl                                       533     Cl          C.sub.3 H.sub.7 (n)                                                                     H                                                 534     Cl          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   535     Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       536     Cl          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        537     Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               538     Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               539     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     540     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     541     Cl          C.sub.4 H.sub.9 (n)                                                                     H                                                 542     Cl          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   543     Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       544     Cl          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        545     Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               546     Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               547     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     548     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     549     ethyl       C.sub.3 H.sub.7 (n)                                                                     H                                                 550     ethyl       C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   551     ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       552     ethyl       C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        553     ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               554     ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               555     ethyl       C.sub.4 H.sub.9 (n)                                                                     H                                                 556     ethyl       C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   557     ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       558     ethyl       C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        559     ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               560     ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               561     n-butyl     C.sub.3 H.sub.7 (n)                                                                     H                                                 562     n-butyl     C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   563     n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       564     n-butyl     C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        565     n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               566     n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               567     n-butyl     C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   568     n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       569     n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               570     n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               571     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H                                                 572     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   273     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       ______________________________________                                    

                  TABLE X                                                          ______________________________________                                          ##STR52##                                                                     EX. #  R.sup.31        R.sup.32 R.sup.33                                       ______________________________________                                         574    H               C.sub.3 H.sub.7 (n)                                                                     O                                              575    H               C.sub.3 H.sub.7 (n)                                                                     S                                              576    H               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   577    H               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   578    H               C.sub.3 H.sub.7 (n)                                                                     NOH                                            579    H               C.sub.4 H.sub.9 (n)                                                                     O                                              580    H               C.sub.4 H.sub.9 (n)                                                                     S                                              581    H               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   582    H               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   583    H               C.sub.4 H.sub.9 (n)                                                                     NOH                                            584    Cl              C.sub.3 H.sub.7 (n)                                                                     O                                              585    Cl              C.sub.3 H.sub.7 (n)                                                                     S                                              586    Cl              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   587    Cl              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   588    Cl              C.sub.3 H.sub.7 (n)                                                                     NOH                                            589    Cl              C.sub.4 H.sub.9 (n)                                                                     O                                              590    Cl              C.sub.4 H.sub.9 (n)                                                                     S                                              591    Cl              C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   592    Cl              C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   593    Cl              C.sub.4 H.sub.9 (n)                                                                     NOH                                            594    C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                     O                                              595    C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                     S                                              596    C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   597    C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   598    C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                     NOH                                            599    C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                     O                                              600    C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                     S                                              601    C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   602    C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   603    C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                     NOH                                            604    C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                     O                                              605    C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                     S                                              606    C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   607    C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   608    C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                     NOH                                            609    C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                     O                                              610    C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                     S                                              611    C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   612    C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   613    C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                     NOH                                            614    (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                     O                                              615    (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                     S                                              616    (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   617    (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                     NOH                                            618    (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                     O                                              619    (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                     S                                              620    (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   621    (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                     NOH                                            622    (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                     O                                              623    (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                     S                                              624    (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   625    (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                     NOH                                            626    (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                     O                                              627    (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                     S                                              628    (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   629    (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                     NOH                                            ______________________________________                                    

                  TABLE XI                                                         ______________________________________                                          ##STR53##                                                                     EX. #    R.sup.34        R.sup.35  R.sup.36                                    ______________________________________                                         630      H               C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             631      H               C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         632      H               C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             633      H               C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         634      Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             635      Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         636      Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             637      Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         638      C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             639      C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         640      C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             641      C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         642      C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             643      C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             644      (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             645      (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             646      (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             647      (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             ______________________________________                                    

                  TABLE XII                                                        ______________________________________                                          ##STR54##                                                                     EX. #   R.sup.37       R.sup.38 R.sup.39                                       ______________________________________                                         648     H              C.sub.3 H.sub.7 (n)                                                                     H                                              649     H              C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       650     H              C.sub.3 H.sub.7 (n)                                                                     OH                                             651     H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    652     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                653     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            654     H              C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                655     H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       656     H              C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                657     H              C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      658     H              C.sub.4 H.sub.9 (n)                                                                     H                                              659     H              C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       660     H              C.sub.4 H.sub.9 (n)                                                                     OH                                             661     H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    662     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                663     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            664     H              C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                665     H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       666     H              C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                667     H              C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      668     Cl             C.sub.3 H.sub.7 (n)                                                                     H                                              669     Cl             C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       670     Cl             C.sub.3 H.sub.7 (n)                                                                     OH                                             671     Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    672     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                673     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            674     Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                675     Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       676     Cl             C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                677     Cl             C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      678     Cl             C.sub.4 H.sub.9 (n)                                                                     H                                              679     Cl             C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       680     Cl             C.sub.4 H.sub.9 (n)                                                                     OH                                             681     Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    682     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                683     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            684     Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                685     Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       686     Cl             C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                687     Cl             C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      688     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              689     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       690     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             691     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    692     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                693     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      694     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              695     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       696     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             697     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    698     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                699     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      700     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     H                                              701     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       702     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     OH                                             703     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    704     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                705     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                       706     C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H.sub.5                      707     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     H                                              708     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       709     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     OH                                             710     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    711     C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                712     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              713     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       714     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             715     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    716     (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                717     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              718     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       719     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             720     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    721     (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                722     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     H                                              723     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       724     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     OH                                             725     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    726     (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                727     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     H                                              728     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       729     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     OH                                             730     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    731     (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE XIII                                                       ______________________________________                                          ##STR55##                                                                     EX. # R.sup.40      R.sup.41 R.sup.42                                                                              R.sup.43                                   ______________________________________                                         732   H             C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   733   H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   734   H             C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                                                              CH.sub.3                                   735   H             C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   736   H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   737   H             C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                                                              CH.sub.3                                   738   Cl            C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   739   Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   740   Cl            C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                                                              CH.sub.3                                   741   Cl            C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   742   Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   743   Cl            C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                                                              CH.sub.3                                   744   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   745   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   746   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   747   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   748   C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   749   C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   750   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   751   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   752   (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   753   (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   754   (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   755   (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   756   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   757   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   758   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   759   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   760   H             C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            761   H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            762   H             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            763   H             C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            764   H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            765   H             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            766   Cl            C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            767   Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            768   Cl            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            769   Cl            C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            770   Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            771   Cl            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            772   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            773   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            774   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            775   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            776   (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            777   (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            778   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            779   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            780   H             C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            781   H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            782   H             C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            783   H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            784   Cl            C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            785   Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            786   Cl            C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            787   Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            788   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            789   C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            790   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            791   C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            792   C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            793   C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            794   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            795   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            796   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               797   C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               798   (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               799   (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               800   (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               801   (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               802   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               803   (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               804   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               805   (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               ______________________________________                                    

                  TABLE XIV                                                        ______________________________________                                          ##STR56##                                                                     EX. #     R.sup.44     R.sup.45   R.sup.46,R.sup.47                            ______________________________________                                         806       H            C.sub.3 H.sub.7 (n)                                                                       O                                            807       H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          808       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   809       H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            810       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                811       H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 812       H            C.sub.4 H.sub.9 (n)                                                                       O                                            813       H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          814       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   815       H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            816       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                817       H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 818       Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            819       Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          820       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   821       Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            822       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                823       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 824       Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            825       Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          826       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   827       Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            828       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                829       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 830       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            831       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          832       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   833       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            834       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                835       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 836       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            837       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          838       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   839       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            840       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                841       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 842       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            843       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          844       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   845       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                846       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 847       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            848       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          849       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   850       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                851       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 852       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            853       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          854       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   855       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            856       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                857       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 858       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            859       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          860       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   861       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            862       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                863       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE XV                                                         ______________________________________                                          ##STR57##                                                                     EX. #     R.sup.48     R.sup.49   R.sup.50,R.sup.51                            ______________________________________                                         864       H            C.sub.3 H.sub.7 (n)                                                                       O                                            865       H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          866       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   867       H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            868       H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                869       H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 870       H            C.sub.4 H.sub.9 (n)                                                                       O                                            871       H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          872       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   873       H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            874       H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                875       H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 876       Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            877       Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          878       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   879       Cl           C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            880       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                881       Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 882       Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            883       Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          884       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   885       Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            886       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                887       Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 888       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            889       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          890       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   891       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            892       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                893       C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 894       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            895       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          896       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   897       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            898       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                899       C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 900       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            901       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          902       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   903       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                904       C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 905       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            906       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          907       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   908       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                909       C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 910       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            911       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          912       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   913       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            914       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                915       (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 916       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            917       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          918       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   919       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            920       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                921       (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE XVI                                                        ______________________________________                                          ##STR58##                                                                     EX. # R.sup.52       R.sup.53 R.sup.54                                         ______________________________________                                         922   H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         923   H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              924   H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     925   H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                926   H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      927   H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             928   H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         929   H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              930   H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     931   H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                932   H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      933   H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             934   Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         935   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              936   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     937   Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                938   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      939   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             940   Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         941   Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              942   Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     943   Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                944   Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      945   Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             946   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         947   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              948   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     949   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                950   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      951   C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             952   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         953   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              954   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     955   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                956   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      957   C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             958   C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         959   C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                960   C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         961   C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                962   (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         963   (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                964   (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         965   (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                966   (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         967   (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                968   (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         969   (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                ______________________________________                                    

                  TABLE XVII                                                       ______________________________________                                          ##STR59##                                                                     EX. # R.sup.55       R.sup.56 R.sup.57                                         ______________________________________                                         970   H              C.sub.3 H.sub.7 (n)                                                                     H                                                971   H              C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  972   H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      973   H              C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       974   H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              975   H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              976   H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                    977   H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.                                   3                                                978   H              C.sub.3 H.sub.7 (n)                                                                     phenyl                                           979   H              C.sub.3 H.sub.7 (n)                                                                     benzyl                                           980   H              C.sub.3 H.sub.7 (n)                                                                     phenylethyl                                      981   H              C.sub.4 H.sub.9 (n)                                                                     H                                                982   H              C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  983   H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      984   H              C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       985   H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              986   H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              987   H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                    988   H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.                                   3                                                989   H              C.sub.4 H.sub.9 (n)                                                                     phenyl                                           990   H              C.sub.4 H.sub.9 (n)                                                                     benzyl                                           991   H              C.sub.4 H.sub.9 (n)                                                                     phenylethyl                                      992   Cl             C.sub.3 H.sub.7 (n)                                                                     H                                                993   Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  994   Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      995   Cl             C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       996   Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              997   Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              998   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                    999   Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.                                   3                                                1000  Cl             C.sub.4 H.sub.9 (n)                                                                     H                                                1001  Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  1002  Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      1003  Cl             C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       1004  Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              1005  Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1006  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                    1007  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.                                   3                                                1008  ethyl          C.sub.3 H.sub.7 (n)                                                                     H                                                1009  ethyl          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  1010  ethyl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      1011  ethyl          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       1012  ethyl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              1013  ethyl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1014  ethyl          C.sub.4 H.sub.9 (n)                                                                     H                                                1015  ethyl          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  1016  ethyl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      1017  ethyl          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       1018  ethyl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              1019  ethyl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1020  n-butyl        C.sub.3 H.sub.7 (n)                                                                     H                                                1021  n-butyl        C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  1022  n-butyl        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      1023  n-butyl        C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       1024  n-butyl        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              1025  n-butyl        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1026  n-butyl        C.sub.4 H.sub.9 (n)                                                                     H                                                1027  n-butyl        C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  1028  n-butyl        C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      1029  n-butyl        C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       1030  n-butyl        C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              1031  n-butyl        C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1032  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                                1033  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  1034  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      1035  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       1036  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              1037  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1038  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                                1039  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  1040  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      1041  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       1042  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              1043  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1044  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     H                                                1045  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  1046  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                      1047  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                       1048  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              1049  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              1050  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     H                                                1051  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                  1052  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                      1053  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                       1054  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                              1055  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3              ______________________________________                                    

                  TABLE XVIII                                                      ______________________________________                                          ##STR60##                                                                     EX. #   R.sup.58       R.sup.59 R.sup.60                                       ______________________________________                                         1056    H              C.sub.3 H.sub.7 (n)                                                                     O                                              1057    H              C.sub.3 H.sub.7 (n)                                                                     S                                              1058    H              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1059    H              C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1060    H              C.sub.3 H.sub.7 (n)                                                                     NOH                                            1061    H              C.sub.4 H.sub.9 (n)                                                                     O                                              1062    H              C.sub.4 H.sub.9 (n)                                                                     S                                              1063    H              C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1064    H              C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1065    H              C.sub.4 H.sub.9 (n)                                                                     NOH                                            1066    Cl             C.sub.3 H.sub.7 (n)                                                                     O                                              1067    Cl             C.sub.3 H.sub.7 (n)                                                                     S                                              1068    Cl             C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1069    Cl             C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1070    Cl             C.sub.3 H.sub.7 (n)                                                                     NOH                                            1071    Cl             C.sub.4 H.sub.9 (n)                                                                     O                                              1072    Cl             C.sub.4 H.sub.9 (n)                                                                     S                                              1073    Cl             C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1074    Cl             C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1075    Cl             C.sub.4 H.sub.9 (n)                                                                     NOH                                            1076    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     O                                              1077    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     S                                              1078    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1079    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1080    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     NOH                                            1081    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     O                                              1082    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     S                                              1083    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1084    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1085    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     NOH                                            1086    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     O                                              1087    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     S                                              1088    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1089    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1090    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     NOH                                            1091    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     O                                              1092    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     S                                              1093    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1094    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 C(CH.sub.3).sub.3                   1095    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     NOH                                            1096    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     O                                              1097    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     S                                              1098    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1099    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     NOH                                            1100    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     O                                              1101    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     S                                              1102    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1103    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     NOH                                            1104    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     O                                              1105    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     S                                              1106    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CHCO.sub.2 H                                   1107    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     NOH                                            1108    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     O                                              1109    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     S                                              1110    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CHCO.sub.2 H                                   1111    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     NOH                                            ______________________________________                                    

                  TABLE XIX                                                        ______________________________________                                          ##STR61##                                                                     EX. #    R.sup.61        R.sup.62  R.sup.63                                    ______________________________________                                         1112     H               C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1113     H               C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         1114     H               C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             1115     H               C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         1116     Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1117     Cl              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         1118     Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             1119     Cl              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         1120     C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1121     C.sub.2 H.sub.5 C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                         1122     C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             1123     C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                         1124     C.sub.4 H.sub.9 (n)                                                                            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1125     C.sub.4 H.sub.9 (n)                                                                            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             1126     (2-ethylphenyl) C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1127     (2-ethylphenyl) C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             1128     (2,6-dimethylphenyl)                                                                           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                             1129     (2,6-dimethylphenyl)                                                                           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                             ______________________________________                                    

                  TABLE XX                                                         ______________________________________                                          ##STR62##                                                                     EX. #   R.sup.64       R.sup.65 R.sup.66                                       ______________________________________                                         1130    H              C.sub.3 H.sub.7 (n)                                                                     H                                              1131    H              C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1132    H              C.sub.3 H.sub.7 (n)                                                                     OH                                             1133    H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1134    H              C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1135    H              C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            1136    H              C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                1137    H              C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                       1138    H              C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                1139    H              C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H                            1140    H              C.sub.4 H.sub.9 (n)                                                                     H                                              1141    H              C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1142    H              C.sub.4 H.sub.9 (n)                                                                     OH                                             1143    H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1144    H              C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                1145    H              C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            1146    H              C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                1147    H              C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                       1148    H              C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                1149    H              C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H                            1150    Cl             C.sub.3 H.sub.7 (n)                                                                     H                                              1151    Cl             C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1152    Cl             C.sub.3 H.sub.7 (n)                                                                     OH                                             1153    Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1154    Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1155    Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.3 H.sub.7 (n)                            1156    Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                1157    Cl             C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                       1158    Cl             C.sub.3 H.sub.7 (n)                                                                     (2-ethylphenyl)                                1159    Cl             C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H                            1160    Cl             C.sub.4 H.sub.9 (n)                                                                     H                                              1161    Cl             C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1162    Cl             C.sub.4 H.sub.9 (n)                                                                     OH                                             1163    Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1164    Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                1165    Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.3 H.sub.7 (n)                            1166    Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5                                1167    Cl             C.sub.4 H.sub.9 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                       1168    Cl             C.sub.4 H.sub.9 (n)                                                                     (2-ethylphenyl)                                1169    Cl             C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H                            1170    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              1171    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1172    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             1173    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1174    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1175    C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     OCH.sub.2 C.sub.6 H                            1176    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              1177    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1178    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             1179    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1180    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                1181    C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     OCH.sub.2 C.sub.6 H                            1182    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     H                                              1183    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1184    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     OH                                             1185    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1186    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1187    C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                       1188    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     H                                              1189    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1190    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     OH                                             1191    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1192    C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                1193    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     H                                              1194    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1195    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     OH                                             1196    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1197    (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1198    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     H                                              1199    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1200    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     OH                                             1201    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1202    (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                1203    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     H                                              1204    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     NH.sub.2                                       1205    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     OH                                             1206    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                    1207    (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                1208    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     H                                              1209    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     NH.sub.2                                       1210    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     OH                                             1211    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                    1212    (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE XXI                                                        ______________________________________                                          ##STR63##                                                                     EX. # R.sup.67      R.sup.68 R.sup.69                                                                              R.sup.70                                   ______________________________________                                         1213  H             C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1214  H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1215  H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                              CH.sub.3                                   1216  H             C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1217  H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1218  H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                              CH.sub.3                                   1219  Cl            C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1220  Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1221  Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                              CH.sub.3                                   1222  Cl            C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1223  Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1224  Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                              CH.sub.3                                   1225  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1226  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1227  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1228  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1229  C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1230  C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1231  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1232  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1233  (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1234  (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1235  (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1236  (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1237  (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.3                                   1238  (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1239  (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.3                                   1240  (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.3                                   1241  H             C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            1242  H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1243  H             C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            1244  H             C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            1245  H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1246  H             C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            1247  Cl            C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            1248  Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1249  Cl            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            1250  Cl            C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            1251  Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1252  Cl            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                            1253  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            1254  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1255  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            1256  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.2 H.sub.5                            1257  (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            1258  (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            1259  (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      C.sub.2 H.sub.5                            1260  (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      C.sub.2 H.sub.5                            1261  H             C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            1262  H             C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1263  H             C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            1264  H             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1265  Cl            C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            1266  Cl            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1267  Cl            C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            1268  Cl            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1269  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            1270  C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1271  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            1272  C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1273  C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     H      C.sub.6 H.sub.5                            1274  C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1275  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      C.sub.6 H.sub.5                            1276  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              C.sub.6 H.sub.5                            1277  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               1278  C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               1279  (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               1280  (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               1281  (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               1282  (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               1283  (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               1284  (2,6-dimethylphenyl)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               1285  (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     H      CH.sub.2 CH.sub.2 CO.sub.2 H               1286  (2,6-dimethylphenyl)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 H               ______________________________________                                    

                  TABLE XXII                                                       ______________________________________                                          ##STR64##                                                                     EX. #     R.sup.71     R.sup.72   R.sup.73,R.sup.74                            ______________________________________                                         1287      H            C.sub.3 H.sub.7 (n)                                                                       O                                            1288      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          1289      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1290      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            1291      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1292      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1293      H            C.sub.4 H.sub.9 (n)                                                                       O                                            1294      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          1295      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1296      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1297      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1298      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1299      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            1300      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          1301      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1302      Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            1303      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1304      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1305      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            1306      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          1307      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1308      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1309      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1310      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1311      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            1312      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          1313      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1314      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            1315      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1316      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1317      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            1318      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          1319      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1320      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1321      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1322      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1323      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            1324      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          1325      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1326      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1327      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1328      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            1329      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          1330      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1331      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1332      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1333      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            1334      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          1335      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1336      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            1337      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1338      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1339      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            1340      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          1341      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1342      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            1343      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1344      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE XXIII                                                      ______________________________________                                          ##STR65##                                                                     EX. #     R.sup.75     R.sup.76   R.sup.77,R.sup.78                            ______________________________________                                         1345      H            C.sub.3 H.sub.7 (n)                                                                       O                                            1346      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          1347      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1348      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            1349      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1350      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1351      H            C.sub.4 H.sub.9 (n)                                                                       O                                            1352      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          1353      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1354      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1355      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1356      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1357      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            1358      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          1359      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1360      Cl           C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            1361      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1362      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1363      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            1364      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          1365      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1366      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1367      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1368      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1369      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            1370      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          1371      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1372      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            1373      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1374      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1375      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            1376      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          1377      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1378      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            1379      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1380      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1381      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            1382      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          1383      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1384      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1385      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1386      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            1387      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          1388      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1389      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1390      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 1391      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            1392      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          1393      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   1394      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            1395      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                1396      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 1397      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            1398      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          1399      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   1400      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            1401      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                1402      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE XXIV                                                       ______________________________________                                          ##STR66##                                                                     EX. # R.sup.79       R.sup.80 R.sup.81                                         ______________________________________                                         1403  H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1404  H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              1405  H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1406  H              C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1407  H              C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1408  H              C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1409  H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1410  H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              1411  H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1412  H              C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                1413  H              C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1414  H              C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1415  Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1416  Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              1417  Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1418  Cl             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1419  Cl             C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1420  Cl             C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1421  Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1422  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              1423  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1424  Cl             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                1425  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1426  Cl             C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1427  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1428  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              1429  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1430  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1431  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1432  C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1433  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1434  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              1435  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     1436  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                1437  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      1438  C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             1439  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1440  C.sub.4 H.sub.9 (n)                                                                           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1441  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1442  C.sub.4 H.sub.9 (n)                                                                           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                1443  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1444  (2-ethylphenyl)                                                                               C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1445  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1446  (2-ethylphenyl)                                                                               C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                1447  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         1448  (2,6-dimethylphenyl)                                                                          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                1449  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         1450  (2,6-dimethylphenyl)                                                                          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                ______________________________________                                    

An appropriately substituted imidazole 31, the heterocyclic starting material, may be prepared as described in the literature Klaus Hofmann, in "Imidazole and its Derivatives" of The Chemistry of Heterocyclic Compounds, Arnold Weissberger Ed., Wiley Interscience New York, 1953!. The imidazole 31 in N,N-dimethylformamide (DMF) is treated with base, such as potassium tert-butoxide, followed by addition of appropriate alkylating agent 32 to give the coupled product 32 (Scheme V). For compounds where X is a substituted phenyl group, several procedures have been published for the preparations of the alkylating agent 32 see references for compound 2!.

The arylated imidazole 33 itself may be an angiotensin II receptor antagonist, but it may also be used as a key intermediate in the preparation of the compounds of the invention. Imidazole 33 in THF (or DME) is treated with base (such as n-BuLi or LDA) at -78° C. (or -65° C.), followed by addition of an appropriate alkylating agent or other electrophiles 34 (the acetal shown in Scheme V may be other aldehyde masking group or equivalent, and LG is a leaving group such as halide, triflate or tosylate). The resulting masked aldehyde 35 was stirred with NaOAc in aqueous acetic acid at reflux for a few days (1 to 5 days) to give one of the described invention compounds, a cyclized imidazole 36. ##STR67##

The imidazole 36may be used as an intermediate to prepare other substituted compounds with appropriate functional group transformations and preparations of some of those compounds are illustrated in Scheme VI (all of the intermediates shown in the sequences are also angiotensin II receptor antagonists). For example, The unsaturated imidazole 36 and NBS in CCl₄ is stirred at reflux to give a bromide 37. The imidazole 36 may be hydrogenated to give its saturated product 39. ##STR68##

Alternatively, as illustrated in Scheme VII, the unsaturated imidazole 36 may be treated with NBS in wet DMSO to give a bromohydrin which may be reduced with nBu₃ SnH to an alcohol 40 and the oxidation of the alcohol with MnO₂ will afford a ketone 41. The ketone 41 may be condensed with appropriately substituted amine, then reduced to an amine 42 with an appropriate reducing agent (e.g. NaBH₄, or hydrogen over catalyst). The amine 42 may also be prepared directly from olefin 36 under bromination condition (NBS, CH₃ CN) with a large excess of succinimide. The amine 42 may be used to prepare other derivatives. Alternatively, the alcohol 40 may be treated with triphenylphosphine, diethoxyazo dicarboxylate and an imide (e.g. phthalimide) to give an imide analogue which may be converted to an amine 42.

The ketone 41 may be treated with appropriate organometallic reagents (such as Grignard, organolithium, organocerium or organozinc reagents) to give the additional product, a tertiary alcohol. The alcohol may be dehydrated to give an olefin 43 or an isomeric mixture of olefins 43. The olefin 43 may be treated with base, such as LDA and kinetically quenched with either organic acid or appropriate electrophile at low temperature to give the isomerized olefin 44. The olefins 43 or 44 may be hydrogenated to its saturated analogue 45. Alternatively, olefin 44 can be prepared from ketone 41 by treatment with an appropriate organometallic reagent, such as a Grignard reagent. ##STR69##

In Scheme VIII, an alternative preparation for the compounds of the invention is described. An appropriately substituted imidazole 31 may be treated with one equivalent of base, then protected as SEM or BOC derivative. The protected imidazole then is treated with another equivalent of base followed by addition of electrophile 46 or 47. If necessary, the resulting lithium anion obtained from the procedure described above may be converted to other organometallic reagents according to well-established procedures. Electrophiles 47 and 48 can be prepared from HC(═O)(CR⁴ R⁵)(CH₂)_(n) C(═O)LG and an appropriate organometallic reagent such as XC₆ H₄ MgBr.

If PLG is an hydroxyl group and Z is a proton, the resulting addition product 49, may be cyclized with triphenylphosphine and diethyl azodicarboxylate (Mitsunobu reaction or other modified conditions). If PLG is or is converted to a leaving group, such as halides, tosylate, and Z is a proton, the cyclization may be achieved with a weak base in DMF (e.g. K₂ CO₃, CsCO₃) to give a ketone 41. The ketone 41 may be reduced to an alcohol 40 with NaBH₄ in methanol. The alcohol 40 may be dehydrated to olefin 36 with acid (e.g. HOAc and heat) or thionyl chloride and pyridine. Other compounds may be prepared from compounds 36, 40, or 41 as described in Scheme VI and VII. ##STR70##

EXAMPLE 1451 ##STR71## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridine

Step 1: Preparation of biphenyl imidazole

To a solution of 4-butylimidazole (2.65 mmol) in 5.3 ml of DMF is added 3.45 ml (3.45 mmol) of potassium tert-butoxide (1M in THF), and the resulting solution is stirred at room temperature for 30 min. To the dark brown mixture is added 2.75 g (3.45 mmol) of the bromomethyl biphenyl. The reaction mixture is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl imidazole.

Step 2: Preparation of dimethyl acetal imidazole

To a solution of biphenyl imidazole (3.18 mmol, obtained from Step 1) in 16 mL of THF cooled at -45° C. (acetonitrile-dry ice) is added 2.8 mL (4.06 mmol) of n-butyllithium (1.45M in hexane) over a 4 minute period. The resulting dark purple solution is stirred cold for another 15 minutes, followed by addition of 1.0 mL (6.59 mmol) of 3-bromopropionaldehyde dimethyl acetal in one portion. The mixture is stirred cold for 40 minutes, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄), concentrated in vacuo and purified to give the biphenyl dimethyl acetal imidazole intermediate.

Step 3: Preparation of biphenyl bicyclic imidazole

A solution of the crude biphenyl dimethyl acetal imidazole (3.18 mmol, obtained from Step 2) and 5.3 g (88 mmol) of NaOAc in 13 mL of water and 40 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The solution is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 2 g (7.2 mmol) of trityl chloride and 3 mL (21.5 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl bicyclic imidazole.

Step 4: Detritylation of trityl tetrazole

A solution of the biphenyl bicyclic imidazole (0.144 mmol, obtained from Step 3) is stirred with 1 mL of water and 6 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo, stirred in aqueous NaHCO₃ and washed with ether. The aqueous residue is acidified with 3N HCl to pH 4 and extracted with methylene chloride. The combined extracts are dried (MgSO₄), concentrated and purified to give the title compound of Example 1451.

EXAMPLE 1452 ##STR72## 7-Bromo-3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridine

Step 1: Preparation of bromo olefin imidazole

A solution of trityl-protected bicyclic imidazole (0.101 mmol, obtained from Step 3 of Example 1451), 20 mg (0.112 mmol) of NBS and 7 mg (catalytic) of AIBN in 2.8 mL of CCl₄ is stirred at reflux until the reaction is complete. The reaction mixture is diluted with CCl₄ and washed with water. The organic layer is dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl bromo olefin imidazole.

Step 2: Detritylation of the trityl tetrazole

A solution of bromo olefin imidazole (0.0427 mmol, obtained from Step 1) in 0.8 mL of water and 5 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451 and purified to give the title compound of Example 1452.

EXAMPLE 1453 ##STR73## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridine

A suspension of bicyclic olefin amidazole (0.1 mmol, the title compound of Example 1451) and 20 mg (0.019 mmol) of 10% palladium on charcoal in 2 mL of absolute ethanol is agitated on a Parr apparatus under 50 psi of hydrogen gas at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1453.

EXAMPLE 1454 ##STR74## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8(5H)-one

Step 1: Preparation of the bromohydrin intermediate

To a solution of biphenyl olefin imidazole (3.13 mmol, obtained from Step 4 of Example 1451) in 2.2 mL (0.122 mmol) of water and 22 mL of DMSO at room temperature is added 587 mg (3.30 mmol) of NBS in one portion. The resulting orange solution is stirred at room temperature for 40 min, quenched with aqueous Na₂ SO₃, and extracted with chloroform. The combined extracts are washed with water, and the combined aqueous layers are extracted with chloroform. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo to give a crude bromohydrin intermediate which can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of the biphenyl hydroxy imidazole

To the crude bromohydrin (3.13 mmol, obtained from Step 1) in 42 mL of degassed dry benzene is added 4.3 mL (14.7 mmol) of n-Bu₃ SnH and 456 mg (2.7 mmol) of AIBN in one portion and the resulting solution is stirred at reflux until the reaction is complete. The mixture is concentrated in vacuo and partitioned between hexane and acetonitrile. The acetonitrile layer is washed with hexane, and the combined hexane layers are extracted with acetonitrile. The combined acetonitrile extracts are concentrated in vacuo to give an isomeric mixture of both cis- and trans-hydroxy imidazoles (relative to the biphenyl moiety). The crude mixture can be used directly in subsequent Step 3 without further purification. The mixture may also be used to prepare the trans-hydroxy title compound of Example 1456.

Step 3: Preparation of the keto imidazole

A suspension of the crude biphenyl hydroxy imidazole (2.72 mmol, obtained from Step 2) and 13 g of active MnO₂ in 15 mL of methylene chloride is stirred at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl keto imidazole.

Step 4: Detritylation of trityl tetrazole

A solution of trityl-protected keto imidazole (0.131 mmol, obtained from Step 3) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451 to give the title compound of Example 1454.

EXAMPLE 1455 ##STR75## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-cis-8-ol

Step 1: Preparation of cis-hydroxy imidazole

To a solution of biphenyl keto imidazole (0.456 mmol, obtained from Step 3 of Example 1454) in 0.5 mL of methanol and 2.0 mL of THF at 0° C. is added in small portions 34 mg (0.899 mmol) of NaBH₄. The resulting solution is stirred at 0° C., and slowly warmed to room temperature. The reaction is quenched with aqueous NH₄ Cl, extracted with methylene chloride, dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl hydroxy imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of the biphenyl hydroxy imidazole (0.259 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 1455.

EXAMPLE 1456 ##STR76##

3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-trans -8-ol

Step 1: Preparation of biphenyl trans-hydroxy imidazole

A suspension of the crude biphenyl hydroxy imidazole (1.307 mmol, obtained from Step 2 of Example 1454) and 3.0 g of active MnO₂ in 5.0 mL of methylene chloride is stirred at room temperature. The reaction is worked up before its completion. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl protected biphenyl trans-hydroxy imidazole.

Alternatively, the biphenyl trans-hydroxy imidazole can be prepared using the Mitsunobu reaction conditions. To a solution of diethyl azodicarboxylate (2.0 mmol) and 3-nitrobenzoic acid (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of the biphenyl hydroxy imidazole (2.0 mmol, obtained from Step 1 of Example 1454), and triphenyl-phosphine (2.0 mmol) in 1.0 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate, and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo to give the biphenyl imidazolyl nitrobenzoate. The crude benzoate is hydrolyzed with LiOH in aqueous THF at room temperture and purified to give the biphenyl trans-hydroxy imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of the trityl protected biphenyl trans-hydroxy imidazole (0.079 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 1456.

EXAMPLE 1457 ##STR77## 1- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8-yl!-2,5-pyrrolidinedione

Step 1: Preparation of succinimidyl imidazole

To a solution of 2.00 g (3.13 mmol) of biphenyl bicyclic imidazole (Example 1451, Step 3) and 1.25 g (12.6 mmol) of succinimide in 20 mL of anhydrous acetonitrile is added 572 mg (3.21 mmol) of NBS in one portion. The resulting orange-red solution is stirred at room temperature for 30 min, then evaporated in vacuo. The residue is dissolved in ethyl acetate and washed with aqueous sodium bisulfite, water,and brine. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl imidazole.

Alternatively, the succinimide can be prepared from its corresponding hydroxy imidazole. To a solution of the biphenyl hydroxy imidazole (2.0 mmol, obtained from Step 1 of Example 1455 or 1456), succinimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of trityl protected succinimidyl imidazole (0.16 mmol, obtained from Step 1) in 0.2 mL of water and 1 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451 and purified to give the title compound of Example 1457.

EXAMPLE 1458 ##STR78## 4- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8-yl!amino!-4-oxobutanoic acid, hydrazide

A solution of succinimidyl imidazole (0.06 mmol, obtained from Example 1457) and 11 μL (5.6 mmol) of hydrazine in 0.5 mL of ethanol is stirred at room temperature until the reaction is complete and concentrated in vacuo to give the title compound of Example 1458.

EXAMPLE 1459 ##STR79## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-5H-imidazo 1,2-a!azepine

Step 1: Alkylation of biphenyl imidazole

To a solution of biphenyl imidazole (0.152 mmol, obtained from Step 2 of Example 1451) in 0.8 mL of DME cooled at -45° C. (acetonitrile-dry ice) is added 125 μL (0.2 mmol) of n-butyllithium (1.6M in hexane) over a 4-min period. The resulting dark red solution is stirred cold for another 15 min, followed by addition of 70 μL (0.37 mmol) of 2-(3-bromopropyl)-5,5-dimethyl-1,3-dioxane in one portion. The mixture is stirred cold for 40 min, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo. The crude product can be used directly in the subsequent Step 2 without purification.

Step 2: Preparation of the bicyclic imidazole

A solution of the crude mixture (0.152 mmol, obtained from Step 1) and 255 mg (3 mmol) of NaOAc in 0.6 mL of water and 2 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The mixture is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 130 mg (0.46 mmol) of trityl chloride and 0.22 mL (1.6 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl bicyclic imidazole.

Step 3: Detritylation of trityl tetrazole

A solution of the biphenyl bicyclic imidazole (0.035 mmol, obtained from Step 2) is stirred with 0.4 mL of water and 2 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451 to give the title compound of Example 1459.

EXAMPLE 1460 ##STR80## 1,1-Dimethylethyl 3-butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo1,2-a!pyridin-8(5H)-ylidene!acetate

Step 1: Preparation of tert-butyl ester

To a suspension of 64 mg (2.63 mmol) of magnesium in 3.0 mL of THF at 55° C. is added two 10-μL portions of 1,2-dibromoethane, 5 min apart. The resulting mixture is stirred at 45° C. for 10 min, followed by dropwise addition of a solution of biphenyl keto imidazole (0.306 mmol, obtained from Step 3 of Example 1453) and 242 μL (1.50 mmol) of tert-butyl bromoacetate in 2.0 mL of THF at 55° C. over a 1 h period. The resulting solution is stirred until the reaction is complete. The mixture is cooled and quenched with aqueous NH₄ Cl. The mixture is extracted with ether, dried (MgSO₄) and concentrated in vacuo. The crude mixture can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of unsaturated butyl ester

To a solution of the crude hydroxy butyl ester (0.306 mmol, obtained from Step 1) and 200 μL (2.47 mmol) of pyridine in 2 mL of methylene chloride at 0° C. is added dropwise 80 μL (1.1 mmol) of thionyl chloride. The resulting dark brown solution is stirred at 0° C. for 1 h, diluted with water and extracted with methylene chloride. The residue is purified to give the biphenyl imidazolyl unsaturated ester.

Step 3: Detritylation of trityl tetrazole

A solution of biphenyl imidazolyl unsaturated ester (0.133 mmol, obtained from Step 2) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451 to give the title compound of Example 1460.

EXAMPLE 1461 ##STR81## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8(5H)-ylidene!acetic acid

To a solution of unsaturated tert-butyl ester (0.0627 mmol, the title compound of Example 1460) in 2 mL of CDCl₃ at room temperature is added 0.5 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting yellow solution is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The crude product is purified to give the title compound of Example 1461.

EXAMPLE 1462 ##STR82## 1,1-Dimethylethyl 3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8-acetate

Step 1: Preparation of deconjugated ester

To a solution of ester (0.237 mmol, obtained from Step 2 of Example 1460) in 4 mL of THF at 0° C. is added 310 μL of 1.5M (0.467 mmol) LDA over a 2-min period, and the resulting solution is stirred at 0° C. for 10 min. The mixture is cooled to -78° C., stirred cold for 5 min, and quenched dropwise at -78° C. with 100 μL of acetic acid in 1 mL of hexane. The mixture is stirred cold, then warmed to room temperature and treated with aqueous NaHCO₃. The mixture is extracted with methylene chloride. The combined extracts are washed with water, dried (MgSO₄) and concentrated in vacuo to give a crude mixture. The crude product is purified to give the biphenyl imidazolyl deconjugated ester.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl imidazolyl deconjugated ester (0.165 mmol, obtained from Step 1) in 1 mL of water and 3 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture was concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1451. The crude product is purified to give the title compound of Example 1462.

EXAMPLE 1463 ##STR83## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8-acetic acid

To a solution of biphenyl imidazolyl tert-butyl ester (0.039 mmol, the title compound of Example in 0.5 mL of chloroform is added 0.25 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is stirred at room temperature until the reaction is complete. The mixture is quenched with methanol and concentrated in vacuo. The residue is purified to give the title compound of Example 1463.

EXAMPLE 1464 ##STR84## 1,1-Dimethylethyl 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-cis-8-acetate

A suspension of the biphenyl imidazolyl unsaturated ester (0.059 mmol, the title compound of Example 1462) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under an atmosphere of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite and concentrated in vacuo. The residue is purified to give the title compound of Example 1464.

EXAMPLE 1465 ##STR85## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-cis-8-acetic acid

To a solution of tert-butyl ester (0.0332 mmol, obtained from Example 1464) in 0.4 mL of CDCl₃ is added 0.2 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is allowed to stand at room temperature until the reaction is complete. The reaction mixture is diluted with methanol and concentrated. The residue is purified to give the title compound of Example 1465.

EXAMPLE 1466 ##STR86## 3-Butyl-5,6-dihydro-N-hydroxy-5- 2'-(1H-tetrazol-5-yl) 1.1'-biphenyl!-4-yl!imidazol 1,2-a!pyridin-8(7H)-imine

A mixture of biphenyl keto imidazole (0.094 mmol, the title compound of Example 1454), 20 mg (0.29 mmol) of N-hydroxyamine (hydrochloride salt) and 30 mg of NaOAc in 2 mL of methanol is stirred at 60° C. until the reaction is complete. The mixture is diluted with chloroform and filtered. The solid is washed with methanol. The filtrate is concentrated in vacuo and purified to give the title compound of Example 1466.

EXAMPLE 1467 ##STR87## 1- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridin-8-yl!phthalimide

Step 1: Preparation of biphenyl phthalimidyl imidazole

To a solution of the hydroxy imidazole (2.0 mmol, obtained from Step 1 of Example 1455 or 1456), phthalimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected phthalimidyl imidazole.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl phthalimidyl imidazole (2.0 mmol, obtained from Step 1) in 2 mL of water and 10 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 5 of Example 1 and purified give the title compound of Example 1467.

EXAMPLE 1468 ##STR88## 3-Butyl-5,6,7,8-tetrahydro-8-amino-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!imidazo 1,2-a!pyridine

A solution of phthalimidyl imidazole (0.6 mmol, the title compound of Example 1467) and 3 μL (1.5 mmol) of hydrazine in 1.0 mL of ethanol is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo, and purified to give the title compound of Example 1468.

Alternatively, the title compound of Example 1468 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, the title compound of Example 1466) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1468.

Examples 1469-1937, located in Tables XXV-XLVIII, are additional conformationally restricted angiotensin II antagonists embraced by Formula III above.

                  TABLE XXV                                                        ______________________________________                                          ##STR89##                                                                     EX. #       R.sup.82   R.sup.83                                                ______________________________________                                         1469        C.sub.3 H.sub.7 (n)                                                                       H                                                       1470        C.sub.3 H.sub.7 (n)                                                                       C.sub.2 H.sub.5                                         1471        C.sub.3 H.sub.7 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1472        C.sub.3 H.sub.7 (n)                                                                       (2-ethylphenyl)                                         1473        C.sub.3 H.sub.7 (n)                                                                       (2,6-dimethylphenyl)                                    1474        C.sub.3 H.sub.7 (n)                                                                       phenyl                                                  1475        C.sub.3 H.sub.7 (n)                                                                       benzyl                                                  1476        C.sub.3 H.sub.7 (n)                                                                       phenylethyl                                             1477        C.sub.3 H.sub.7 (n)                                                                       CH.sub.2 OH                                             1478        C.sub.3 H.sub.7 (n)                                                                       CO.sub.2 H                                              1479        C.sub.3 H.sub.7 (n)                                                                       CH.sub.2 CO.sub.2 H                                     1480        C.sub.4 H.sub.9 (n)                                                                       C.sub.2 H.sub.5                                         1481        C.sub.4 H.sub.9 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1482        C.sub.4 H.sub.9 (n)                                                                       (2-ethylphenyl)                                         1483        C.sub.4 H.sub.9 (n)                                                                       (2,6-dimethylphenyl)                                    1484        C.sub.4 H.sub.9 (n)                                                                       phenyl                                                  1485        C.sub.4 H.sub.9 (n)                                                                       benzyl                                                  1486        C.sub.4 H.sub.9 (n)                                                                       phenylethyl                                             1487        C.sub.4 H.sub.9 (n)                                                                       CH.sub.2 OH                                             1488        C.sub.4 H.sub.9 (n)                                                                       CO.sub.2 H                                              ______________________________________                                    

                  TABLE XXVI                                                       ______________________________________                                          ##STR90##                                                                     EX. #        R.sup.84    R.sup.85                                              ______________________________________                                         1489         C.sub.3 H.sub.7 (n)                                                                        O                                                     1490         C.sub.3 H.sub.7 (n)                                                                        S                                                     1491         C.sub.3 H.sub.7 (n)                                                                        NOH                                                   1492         C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                          1493         C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                          1494         C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                 1495         C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                     1496         C.sub.4 H.sub.9 (n)                                                                        S                                                     1497         C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                          1498         C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                 1499         C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                     ______________________________________                                    

                  TABLE XXVII                                                      ______________________________________                                          ##STR91##                                                                     EX. #          R.sup.86     R.sup.87                                           ______________________________________                                         1500           C.sub.3 H.sub.7 (n)                                                                         C.sub.2 H.sub.5                                    1501           C.sub.3 H.sub.7 (n)                                                                         C.sub.3 H.sub.7 (n)                                1502           C.sub.4 H.sub.9 (n)                                                                         C.sub.2 H.sub.5                                    1503           C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                ______________________________________                                    

                  TABLE XXVIII                                                     ______________________________________                                          ##STR92##                                                                     EX. #       R.sup.88   R.sup.89                                                ______________________________________                                         1504        C.sub.3 H.sub.7 (n)                                                                       H                                                       1505        C.sub.3 H.sub.7 (n)                                                                       C.sub.2 H.sub.5                                         1506        C.sub.3 H.sub.7 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1507        C.sub.3 H.sub.7 (n)                                                                       (2-ethylphenyl)                                         1508        C.sub.3 H.sub.7 (n)                                                                       (2,6-dimethylphenyl)                                    1509        C.sub.3 H.sub.7 (n)                                                                       phenyl                                                  1510        C.sub.3 H.sub.7 (n)                                                                       benzyl                                                  1511        C.sub.3 H.sub.7 (n)                                                                       phenylethyl                                             1512        C.sub.3 H.sub.7 (n)                                                                       NH.sub.2                                                1513        C.sub.3 H.sub.7 (n)                                                                       OH                                                      1514        C.sub.3 H.sub.7 (n)                                                                       CH.sub.2 OH                                             1515        C.sub.3 H.sub.7 (n)                                                                       CO.sub.2 H                                              1516        C.sub.3 H.sub.7 (n)                                                                       OCH.sub.2 C.sub.6 H                                     1517        C.sub.4 H.sub.9 (n)                                                                       C.sub.2 H.sub.5                                         1518        C.sub.4 H.sub.9 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1519        C.sub.4 H.sub.9 (n)                                                                       (2-ethylphenyl)                                         1520        C.sub.4 H.sub.9 (n)                                                                       (2,6-dimethylphenyl)                                    1521        C.sub.4 H.sub.9 (n)                                                                       phenyl                                                  1522        C.sub.4 H.sub.9 (n)                                                                       benzyl                                                  1523        C.sub.4 H.sub.9 (n)                                                                       phenylethyl                                             1524        C.sub.4 H.sub.9 (n)                                                                       OCH.sub.2 C.sub.6 H                                     1525        C.sub.4 H.sub.9 (n)                                                                       CH.sub.2 OH                                             1526        C.sub.4 H.sub.9 (n)                                                                       CO.sub.2 H                                              ______________________________________                                    

                  TABLE XXIX                                                       ______________________________________                                          ##STR93##                                                                     EX. #     R.sup.90  R.sup.91    R.sup.92                                       ______________________________________                                         1527      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.3                                       1528      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.2 H.sub.5                                1529      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.6 H.sub.5                                1530      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1531      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1532      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1533      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.3                                       1534      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1535      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1536      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1537      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1538      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1539      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1540      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1541      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1542      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1543      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1544      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1545      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1546      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1547      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1548      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1549      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1550      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1551      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1552      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1553      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1554      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1555      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   1556      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.3                                       1557      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.2 H.sub.5                                1558      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.6 H.sub.5                                1559      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1560      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1561      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1562      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.3                                       1563      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1564      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1565      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1566      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1567      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1568      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1569      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1570      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1571      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1572      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1573      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1574      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1575      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1576      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1577      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1578      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1579      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1580      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1581      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1582      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1583      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1584      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   ______________________________________                                    

                  TABLE XXX                                                        ______________________________________                                          ##STR94##                                                                     EX. #         R.sup.93    R.sup.94,R.sup.95                                    ______________________________________                                         1585          C.sub.3 H.sub.7 (n)                                                                        O                                                    1586          C.sub.3 H.sub.7 (n)                                                                        H,H                                                  1587          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.3                                           1588          C.sub.3 H.sub.7 (n)                                                                        H,C.sub.2 H.sub.5                                    1589          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.2 OH                                        1590          C.sub.3 H.sub.7 (n)                                                                        H,CO.sub.2 H                                         1591          C.sub.4 H.sub.9 (n)                                                                        H,H                                                  1592          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.3                                           1593          C.sub.4 H.sub.9 (n)                                                                        H,C.sub.2 H.sub.5                                    1594          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.2 OH                                        1595          C.sub.4 H.sub.9 (n)                                                                        H,CO.sub.2 H                                         ______________________________________                                    

                  TABLE XXXI                                                       ______________________________________                                          ##STR95##                                                                     EX. #         R.sup.96    R.sup.97,R.sup.98                                    ______________________________________                                         1596          C.sub.3 H.sub.7 (n)                                                                        O                                                    1597          C.sub.3 H.sub.7 (n)                                                                        H,H                                                  1598          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.3                                           1599          C.sub.3 H.sub.7 (n)                                                                        H,C.sub.2 H.sub.5                                    1600          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.2 OH                                        1601          C.sub.3 H.sub.7 (n)                                                                        H,CO.sub.2 H                                         1602          C.sub.4 H.sub.9 (n)                                                                        O                                                    1603          C.sub.4 H.sub.9 (n)                                                                        H,H                                                  1604          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.3                                           1605          C.sub.4 H.sub.9 (n)                                                                        H,C.sub.2 H.sub.5                                    1606          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.2 OH                                        1607          C.sub.4 H.sub.9 (n)                                                                        H,CO.sub.2 H                                         ______________________________________                                    

                  TABLE XXXII                                                      ______________________________________                                          ##STR96##                                                                     EX. #        R.sup.99    R.sup.100                                             ______________________________________                                         1608         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                              1609         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                   1610         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          1611         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                     1612         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           1613         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  1614         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                   1615         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          1616         C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                     1617         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           1618         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  ______________________________________                                    

                  TABLE XXXIII                                                     ______________________________________                                          ##STR97##                                                                     EX. #       R.sup.101   R.sup.102                                              ______________________________________                                         1619        C.sub.3 H.sub.7 (n)                                                                        H                                                      1620        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        1621        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1622        C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        1623        C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   1624        C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 1625        C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 1626        C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            1627        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            1628        C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             1629        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                                    1630        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        1631        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1632        C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        1633        C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   1634        C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 1635        C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 1636        C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            1637        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            1638        C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             1639        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CO.sub.2 H                                    ______________________________________                                    

                  TABLE XXXIV                                                      ______________________________________                                          ##STR98##                                                                     EX. #        R.sup.103   R.sup.104                                             ______________________________________                                         1640         C.sub.3 H.sub.7 (n)                                                                        O                                                     1641         C.sub.3 H.sub.7 (n)                                                                        S                                                     1642         C.sub.3 H.sub.7 (n)                                                                        NOH                                                   1643         C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                          1644         C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                          1645         C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                 1646         C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                     1647         C.sub.4 H.sub.9 (n)                                                                        O                                                     1648         C.sub.4 H.sub.9 (n)                                                                        S                                                     1649         C.sub.4 H.sub.9 (n)                                                                        NOH                                                   1650         C.sub.4 H.sub.9 (n)                                                                        CHCO.sub.2 H                                          1651         C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                          1652         C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                 1653         C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                     ______________________________________                                    

                  TABLE XXXV                                                       ______________________________________                                          ##STR99##                                                                     EX. #          R.sup.105    R.sup.106                                          ______________________________________                                         1654           C.sub.3 H.sub.7 (n)                                                                         C.sub.2 H.sub.5                                    1655           C.sub.3 H.sub.7 (n)                                                                         C.sub.3 H.sub.7 (n)                                1656           C.sub.4 H.sub.9 (n)                                                                         C.sub.2 H.sub.5                                    1657           C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                ______________________________________                                    

                  TABLE XXXVI                                                      ______________________________________                                          ##STR100##                                                                    EX. #       R.sup.107   R.sup.108                                              ______________________________________                                         1658        C.sub.3 H.sub.7 (n)                                                                        H                                                      1659        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        1660        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1661        C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        1662        C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   1663        C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 1664        C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 1665        C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            1666        C.sub.3 H.sub.7 (n)                                                                        NH.sub.2                                               1667        C.sub.3 H.sub.7 (n)                                                                        OH                                                     1668        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            1669        C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             1670        C.sub.3 H.sub.7 (n)                                                                        OCH.sub.2 C.sub.6 H                                    1671        C.sub.4 H.sub.9 (n)                                                                        H                                                      1672        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        1673        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1674        C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        1675        C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   1676        C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 1677        C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 1678        C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            1679        C.sub.4 H.sub.9 (n)                                                                        NH.sub.2                                               1680        C.sub.4 H.sub.9 (n)                                                                        OH                                                     1681        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            1682        C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             1683        C.sub.4 H.sub.9 (n)                                                                        OCH.sub.2 C.sub.6 H                                    ______________________________________                                    

                  TABLE XXXVII                                                     ______________________________________                                          ##STR101##                                                                    EX. #     R.sup.109 R.sup.110   R.sup.111                                      ______________________________________                                         1684      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.3                                       1685      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.2 H.sub.5                                1686      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.6 H.sub.5                                1687      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1688      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1689      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1690      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2                                       1691      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1692      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1693      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1694      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1695      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1696      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1697      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1698      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1699      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1700      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1701      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1702      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1703      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1704      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1705      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1706      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1707      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1708      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1709      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1710      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1711      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1712      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   1713      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.3                                       1714      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.2 H.sub.5                                1715      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.6 H.sub.5                                1716      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1717      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1718      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1719      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.3                                       1720      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1721      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1722      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1723      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1724      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1725      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1726      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1727      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1728      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1729      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1730      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1731      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1732      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1733      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1734      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1735      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1736      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1737      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1738      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1739      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1740      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1741      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   ______________________________________                                    

                  TABLE XXXVIII                                                    ______________________________________                                          ##STR102##                                                                    EX. #          R.sup.112    R.sup.113,R.sup.114                                ______________________________________                                         1742           C.sub.3 H.sub.7 (n)                                                                         O                                                  1743           C.sub.3 H.sub.7 (n)                                                                         H,H                                                1744           C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.3                                         1745           C.sub.3 H.sub.7 (n)                                                                         H,C.sub.2 H.sub.5                                  1746           C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.2 OH                                      1747           C.sub.3 H.sub.7 (n)                                                                         H,CO.sub.2 H                                       1748           C.sub.4 H.sub.9 (n)                                                                         O                                                  1749           C.sub.4 H.sub.9 (n)                                                                         H,H                                                1750           C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.3                                         1751           C.sub.4 H.sub.9 (n)                                                                         H,C.sub.2 H.sub.5                                  1752           C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.2 OH                                      1753           C.sub.4 H.sub.9 (n)                                                                         H,CO.sub.2 H                                       ______________________________________                                    

                  TABLE XXXIX                                                      ______________________________________                                          ##STR103##                                                                    EX. #          R.sup.115    R.sup.116,R.sup.117                                ______________________________________                                         1754           C.sub.3 H.sub.7 (n)                                                                         O                                                  1755           C.sub.3 H.sub.7 (n)                                                                         H,H                                                1756           C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.3                                         1757           C.sub.3 H.sub.7 (n)                                                                         H,C.sub.2 H.sub.5                                  1758           C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.2 OH                                      1759           C.sub.3 H.sub.7 (n)                                                                         H,CO.sub.2 H                                       1760           C.sub.4 H.sub.9 (n)                                                                         O                                                  1761           C.sub.4 H.sub.9 (n)                                                                         H,H                                                1762           C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.3                                         1763           C.sub.4 H.sub.9 (n)                                                                         H,C.sub.2 H.sub.5                                  1764           C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.2 OH                                      1765           C.sub.4 H.sub.9 (n)                                                                         H,CO.sub.2 H                                       ______________________________________                                    

                  TABLE XL                                                         ______________________________________                                          ##STR104##                                                                    EX. #        R.sup.118   R.sup.119                                             ______________________________________                                         1766         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                              1767         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                   1768         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          1769         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                     1770         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           1771         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  1772         C.sub.4 H.sub.9 (n)                                                                        CH.sub.2                                              1773         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                   1774         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          1775         C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                     1776         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           1777         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  ______________________________________                                    

                  TABLE XLI                                                        ______________________________________                                          ##STR105##                                                                    EX. #       R.sup.120   R.sup.121                                              ______________________________________                                         1778        C.sub.3 H.sub.7 (n)                                                                        H                                                      1779        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        1780        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1781        C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        1782        C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   1783        C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 1784        C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 1785        C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            1786        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            1787        C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             1788        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                                    1789        C.sub.4 H.sub.9 (n)                                                                        H                                                      1790        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        1791        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    1792        C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        1793        C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   1794        C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 1795        C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 1796        C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            1797        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            1798        C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             1799        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CO.sub.2 H                                    ______________________________________                                    

                  TABLE XLII                                                       ______________________________________                                          ##STR106##                                                                    EX. #       R.sup.122   R.sup.123                                              ______________________________________                                         1800        C.sub.3 H.sub.7 (n)                                                                        O                                                      1801        C.sub.3 H.sub.7 (n)                                                                        S                                                      1802        C.sub.3 H.sub.7 (n)                                                                        NOH                                                    1803        C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                           1804        C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           1805        C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  1806        C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                      1807        C.sub.4 H.sub.9 (n)                                                                        O                                                      1808        C.sub.4 H.sub.9 (n)                                                                        S                                                      1809        C.sub.4 H.sub.9 (n)                                                                        NOH                                                    1810        C.sub.4 H.sub.9 (n)                                                                        CHCO.sub.2 H                                           1811        C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           1812        C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  1813        C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                      ______________________________________                                    

                  TABLE XLIII                                                      ______________________________________                                          ##STR107##                                                                    EX. #          R.sup.124    R.sup.125                                          ______________________________________                                         1814           C.sub.3 H.sub.7 (n)                                                                         C.sub.2 H.sub.5                                    1815           C.sub.3 H.sub.7 (n)                                                                         C.sub.3 H.sub.7 (n)                                1816           C.sub.4 H.sub.9 (n)                                                                         C.sub.2 H.sub.5                                    1817           C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                ______________________________________                                    

                  TABLE XLIV                                                       ______________________________________                                          ##STR108##                                                                    EX. #       R.sup.126  R.sup.127                                               ______________________________________                                         1818        C.sub.3 H.sub.7 (n)                                                                       H                                                       1819        C.sub.3 H.sub.7 (n)                                                                       C.sub.2 H.sub.5                                         1820        C.sub.3 H.sub.7 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1821        C.sub.3 H.sub.7 (n)                                                                       (2-ethylphenyl)                                         1822        C.sub.3 H.sub.7 (n)                                                                       (2,6-dimethylphenyl)                                    1823        C.sub.3 H.sub.7 (n)                                                                       phenyl                                                  1824        C.sub.3 H.sub.7 (n)                                                                       benzyl                                                  1825        C.sub.3 H.sub.7 (n)                                                                       phenylethyl                                             1826        C.sub.3 H.sub.7 (n)                                                                       NH.sub.2                                                1827        C.sub.3 H.sub.7 (n)                                                                       OH                                                      1828        C.sub.3 H.sub.7 (n)                                                                       CH.sub.2 OH                                             1829        C.sub.3 H.sub.7 (n)                                                                       CO.sub.2 H                                              1830        C.sub.3 H.sub.7 (n)                                                                       OCH.sub.2 C.sub.6 H                                     1831        C.sub.4 H.sub.9 (n)                                                                       H                                                       1832        C.sub.4 H.sub.9 (n)                                                                       C.sub.2 H.sub.5                                         1833        C.sub.4 H.sub.9 (n)                                                                       C.sub.3 H.sub.7 (n)                                     1834        C.sub.4 H.sub.9 (n)                                                                       (2-ethylphenyl)                                         1835        C.sub.4 H.sub.9 (n)                                                                       (2,6-dimethylphenyl)                                    1836        C.sub.4 H.sub.9 (n)                                                                       phenyl                                                  1837        C.sub.4 H.sub.9 (n)                                                                       benzyl                                                  1838        C.sub.4 H.sub.9 (n)                                                                       phenylethyl                                             1839        C.sub.4 H.sub.9 (n)                                                                       NH.sub.2                                                1840        C.sub.4 H.sub.9 (n)                                                                       OH                                                      1841        C.sub.4 H.sub.9 (n)                                                                       CH.sub.2 OH                                             1842        C.sub.4 H.sub.9 (n)                                                                       CO.sub.2 H                                              1843        C.sub.4 H.sub.9 (n)                                                                       OCH.sub.2 C.sub.6 H                                     ______________________________________                                    

                  TABLE XLV                                                        ______________________________________                                          ##STR109##                                                                    EX. #     R.sup.128 R.sup.129   R.sup.130                                      ______________________________________                                         1844      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.3                                       1845      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.2 H.sub.5                                1846      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.6 H.sub.5                                1847      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1848      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1849      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1850      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.3                                       1851      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1852      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1853      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1854      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1855      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1856      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1857      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1858      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1859      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1860      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1861      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1862      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1863      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1864      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1865      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1866      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1867      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1868      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1869      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1870      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1871      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1872      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   1873      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.3                                       1874      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.2 H.sub.5                                1875      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.6 H.sub.5                                1876      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       1877      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            1878      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   1879      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.3                                       1880      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                1881      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                1882      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       1883      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            1884      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   1885      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       1886      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                1887      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                1888      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       1889      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            1890      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   1891      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       1892      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                1893      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                1894      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       1895      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            1896      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   1897      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       1898      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                1899      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                1900      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            1901      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   ______________________________________                                    

                  TABLE XLVI                                                       ______________________________________                                          ##STR110##                                                                    EX. #         R.sup.131    R.sup.132, R.sup.133                                ______________________________________                                         1902          C.sub.3 H.sub.7 (n)                                                                         O                                                   1903          C.sub.3 H.sub.7 (n)                                                                         H,H                                                 1904          C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.3                                          1905          C.sub.3 H.sub.7 (n)                                                                         H,C.sub.2 H.sub.5                                   1906          C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.2 OH                                       1907          C.sub.3 H.sub.7 (n)                                                                         H,CO.sub.2 H                                        1908          C.sub.4 H.sub.9 (n)                                                                         O                                                   1909          C.sub.4 H.sub.9 (n)                                                                         H,H                                                 1910          C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.3                                          1911          C.sub.4 H.sub.9 (n)                                                                         H,C.sub.2 H.sub.5                                   1912          C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.2 OH                                       1913          C.sub.4 H.sub.9 (n)                                                                         H,CO.sub.2 H                                        ______________________________________                                    

                  TABLE XLVII                                                      ______________________________________                                          ##STR111##                                                                    EX. #         R.sup.134    R.sup.135, R.sup.136                                ______________________________________                                         1914          C.sub.3 H.sub.7 (n)                                                                         O                                                   1915          C.sub.3 H.sub.7 (n)                                                                         H,H                                                 1916          C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.3                                          1917          C.sub.3 H.sub.7 (n)                                                                         H,C.sub.2 H.sub.5                                   1918          C.sub.3 H.sub.7 (n)                                                                         H,CH.sub.2 OH                                       1919          C.sub.3 H.sub.7 (n)                                                                         H,CO.sub.2 H                                        1920          C.sub.4 H.sub.9 (n)                                                                         O                                                   1921          C.sub.4 H.sub.9 (n)                                                                         H,H                                                 1922          C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.3                                          1923          C.sub.4 H.sub.9 (n)                                                                         H,C.sub.2 H.sub.5                                   1924          C.sub.4 H.sub.9 (n)                                                                         H,CH.sub.2 OH                                       1925          C.sub.4 H.sub.9 (n)                                                                         H,CO.sub.2 OH                                       ______________________________________                                    

                  TABLE XLVIII                                                     ______________________________________                                          ##STR112##                                                                    EX. #       R.sup.137   R.sup.136                                              ______________________________________                                         1926        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                               1927        C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                    1928        C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           1929        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                      1930        C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            1931        C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   1932        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2                                               1933        C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                    1934        C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           1935        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                      1936        C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            1937        C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   ______________________________________                                    

An appropriately substituted pyrrole 61, the heterocyclic starting material, may be prepared as described in the literature G. P. Bean and A. H. Jackson; M. Artico; H. J. Anderson; C. E. Loader, A. Gossauer, P. Nesvadba; and N. Dennis in "Pyrroles", Vol 48 of The Chemistry of Heterocyclic Compounds, E. C. Taylor, A. Weissberger Eds., Wiley-Interscience, New York, 1990, pp 105-497!. The pyrrole 1 in N,N-dimethylformamide (DMF) is treated with base, such as potassium tert-butoxide, followed by addition of appropriate alkylating agent 62 to give the coupled product 63 (Scheme IX). For compounds where X is a substituted phenyl group, several procedures have been published for the preparations of the alkylating agent 62 see references for compound 2!. ##STR113##

The coupled pyrrole 63 itself may be an angiotensin II receptor antagonist, but it may also be used as a key intermediate in the preparation of the compounds of the invention. Pyrrole 63 in THF (or DME) is treated with base (such as n-BuLi or LDA) at -78° C. (or -65° C.), followed by addition of an appropriate alkylating agent or other electrophiles 64 (the acetal shown in Scheme I may be other aldehyde masking group or equivalent, and LG is a leaving group such as halide, mesylate, triflate or tosylate). The resulting masked aldehyde 65 was stirred with NaOAc in aqueous acetic acid at reflux for a few days (1 to 5 days) to give one of the compounds of the invention, a cyclized pyrrole 66.

The pyrrole 66 may be used as an intermediate to prepare other substituted compounds with appropriate functional group transformations and preparations of some of those compounds are illustrated in Scheme X and XI (all of the intermediates shown in the sequences are also angiotensin II receptor antagonists). For example, The unsaturated pyrrole 66 and NBS in CCl₄ is stirred at reflux to give a bromide 67. The pyrrole 66 may be hydrogenated to give its saturated product 69. ##STR114##

Alternatively, as illustrated in Scheme XI, the unsaturated pyrrole 66 may be treated with NBS in wet DMSO to give a bromohydrin which may be reduced with nBu₃ SnH to an alcohol 70 and the oxidation of the alcohol with MnO₂ will afford a ketone 71. The ketone 71 may be condensed with appropriately substituted amine, then reduced to an amine 72 with an appropriate reducing agent (e.g. NaBH₄, or hydrogen over catalyst). The amine 72 may also be prepared directly from olefin 66 under bromination condition (NBS, CH₃ CN) in the presence of large excess of succinimide. The amine 72 may be used to prepare other derivatives. Alternatively, the alcohol 70 may be treated with triphenylphosphine, diethoxyazo dicarboxylate and an imide (e.g. phthalimide) to give an imide analogue which may be converted to an amine 72.

The ketone 71 may be treated with appropriate organometallic reagents (such as Grignard, organolithium, organocerium, organozinc reagents or related reagents) to give the addition product, a tertiary alcohol. The alcohol may be dehydrated to give an olefin 73 or an isomeric mixture of olefins 73. The olefin 73 may be treated with base, such as LDA and kinetically quenched at low temperature with either organic acid or appropriate electrophile at low temperature to give the isomerized olefin 74. The olefins 73 or 74may be hydrogenated to its saturated analogue 75. Alternatively, olefin 74 can be prepared from ketone 71 by treatment with an appropriate organometallic reagent, such as a Grignard reagent. ##STR115##

In Scheme XII, an alternative preparation for the compounds of the invention is described. An appropriately substituted pyrrole 61 may be treated with one equivalent of base, then protected as SEM or BOC derivative. The protected pyrrole then is treated with another equivalent of base followed by addition of electrophile 76 or 77. If necessary, the resulting lithium anion obtained from the two procedures described above may be converted to other organometallic reagents according to well-established procedures. Electrophiles 77 and 78 can be prepared from HC(═O)(CR⁴ R⁵)(CH₂)_(n) C(═O)LG and an appropriate organometallic reagent such as XC₆ H₄ MgBr.

If PLG is a hydroxyl group and Z is a proton, the resulting addition product 79, may be cyclized with triphenylphosphine and diethyl azodicarboxylate (Mitsunobu reaction or other modified conditions). If PLG is or is converted to a leaving group, such as halides, tosylate, and Z is a proton, the cyclization may be achieved with a weak base in DMF (e.g. K₂ CO₃, CsCO₃) to give a ketone 71. The ketone 71 may be reduced to an alcohol 70 with NaBH₄ in methanol. The alcohol 70 may be dehydrated to olefin 66 with acid (e.g. HOAc and heat) or thionyl chloride and pyridine. Other compounds may be prepared from compounds 66, 70, or 71 as described in Scheme X and XI. ##STR116##

EXAMPLE 1938 ##STR117## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizine

Step 1: Preparation of biphenyl pyrrole

To a solution of 2-butylpyrrole 2.65 mmol) in 5.3 mL of DMF is added 3.45 mL (3.45 mmol) of potassium tert-butoxide (1M in THF), and the resulting solution is stirred at room temperature for 30 min. To the dark brown mixture is added 2.75 g (3.45 mmol) of the bromomethyl biphenyl. The reaction mixture is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl pyrrole.

Step 2: Preparation of biphenyl dimethyl acetal pyrrole

To a solution of biphenyl pyrrole (3.18 mmol, obtained from Step 1) in 16 mL of THF cooled at -45° C. (acetonitrile-dry ice) is added 2.8 mL (4.06 mmol) of n-butyllithium (1.45M in hexane) over a 4-min period. The resulting dark purple solution is stirred cold for another 15 min, followed by addition of 1.0 mL (6.59 mmol) of 3-bromopropionaldehyde dimethyl acetal in one portion. The mixture is stirred cold for 40 min, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄), concentrated in vacuo and purified to give the biphenyl dimethyl acetal pyrrole intermediate.

Step 3: Preparation of biphenyl indolizine

A solution of the crude biphenyl dimethyl acetal pyrrole (3.18 mmol, obtained from Step 2) and 5.3 g (88 mmol) of NaOAc in 13 mL of water and 40 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The solution is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 2 g (7.2 mmol) of trityl chloride and 3 mL (21.5 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl indolizine.

Step 4: Detritylation of trityl tetrazole

A solution of the biphenyl indolizine (0.144 mmol, obtained from Step 3) is stirred with 1 mL of water and 6 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo, stirred in aqueous NaHCO₃ and washed with ether. The aqueous residue is acidified with 3N HCl to pH 4 and extracted with methylene chloride. The combined extracts are dried (MgSO₄), concentrated and purified to give the title compound of Example 1938.

EXAMPLE 1939 ##STR118## 7-Bromo-3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizine

Step 1: Preparation of bromo olefin indolizine

A solution of biphenyl indolizine (0.101 mmol, obtained from Step 3 of Example 1938), 20 mg (0.112 mmol) of NBS and 7 mg (catalytic) of AIBN in 2.8 mL of CCl₄ is stirred at reflux until the reaction is complete. The reaction mixture is diluted with CCl₄ and washed with water. The organic layer is dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl bromo olefin indolizine.

Step 2: Detritylation of the trityl tetrazole

A solution of bromo olefin indolizine (0.0427 mmol, obtained from Step 1) in 0.8 mL of water and 5 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938 and purified to give the title compound of Example 1939.

EXAMPLE 1940 ##STR119## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol -5-yl) 1,1'-biphenyl!-4-yl!indolizine

A suspension of olefin indolizine (0.1 mmol, the title compound of Example 1938) and 20 mg (0.019 mmol) of 10% palladium on charcoal in 2 mL of absolute ethanol is agitated on a Parr apparatus under 50 psi of hydrogen gas at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1940.

EXAMPLE 1941 ##STR120## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1,-biphenyl!-4-yl!indolizin-8(5H)-one

Step 1: Preparation of the bromohydrin intermediate

To a solution of biphenyl indolizine (3.13 mmol, obtained from Step 4 of Example 1938) in 2.2 mL (0.122 mmol) of water and 22 mL of DMSO at room temperature is added 587 mg (3.30 mmol) of NBS in one portion. The resulting orange solution is stirred at room temperature for 40 min, quenched with aqueous Na₂ SO₃, and extracted with chloroform. The combined extracts are washed with water, and the combined aqueous layers are extracted with chloroform. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo to give a crude bromohydrin intermediate which can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of the trityl-protected biphenyl hydroxy indolizine

To the crude bromohydrin (3.13 mmol, obtained from Step 1) in 42 mL of degassed dry benzene is added 4.3 mL (14.7 mmol) of n-Bu₃ SnH and 456 mg (2.7 mmol) of AIBN in one portion and the resulting solution is stirred at reflux until the reaction is complete. The mixture is concentrated in vacuo and partitioned between hexane and acetonitrile. The acetonitrile layer is washed with hexane, and the combined hexane layers are extracted with acetonitrile. The combined acetonitrile extracts are concentrated in vacuo to give an isomeric mixture of both cis- and trans-hydroxy indolizines (relative to the biphenyl moiety). The crude mixture can be used directly in subsequent Step 3 without further purification. The mixture may also be used to prepare the biphenyl trans-hydroxy indolizine (the title compound of Example 1943).

Step 3: Preparation of the keto indolizine

A suspension of the crude biphenyl hydroxy indolizine (2.72 mmol, obtained from Step 2) and 13 g of active MnO₂ in 15 mL of methylene chloride is stirred at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl keto indolizine.

Step 4: Detritylation of trityl tetrazole

A solution of trityl tetrazolyl keto indolizine (0.131 mmol, obtained from Step 3) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938 and purified to give the title compound of Example 1941.

EXAMPLE 1942 ##STR121## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol -5-yl) 1,1'-biphenyl!-4-yl!indolizin-cis-8-ol

Step 1: Preparation of biphenyl cis-hydroxy indolizine

To a solution of biphenyl keto indolizine (0.456 mmol, obtained from Step 3 of Example 1941) in 0.5 mL of methanol and 2.0 mL of THF at 0° C. is added in small portions 34 mg (0.899 mmol) of NaBH₄. The resulting solution is stirred at 0° C., and slowly warmed to room temperature. The reaction is quenched with aqueous NH₄ Cl, extracted with methylene chloride, dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl hydroxy indolizine.

Step 2: Detritylation of trityl tetrazole

A solution of the biphenyl hydroxy indolizine (0.259 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 1942.

EXAMPLE 1943 ##STR122## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-trans-8-ol

Step 1: Preparation of biphenyl trans-hydroxy indolizine

A suspension of the crude biphenyl hydroxy indolizine (1.307 mmol, obtained from Step 2 of Example 1941) and 3.0 g of active MnO₂ in 5.0 mL of methylene chloride is stirred at room temperature. The reaction is worked up before its completion. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl protected biphenyl trans-hydroxy indolizine.

Alternatively, the biphenyl trans-hydroxy indolizine can be prepared using the Mitsunobu reaction conditions. To a solution of diethyl azodicarboxylate (2.0 mmol) and 3-nitrobenzoic acid (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of the biphenyl hydroxy indolizine (2.0 mmol, obtained from Step 1 of Example 1942), and triphenylphosphine (2.0 mmol) in 1.0 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate, and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo to give the biphenyl indolizinyl nitrobenzoate. The crude benzoate is hydrolyzed with LiOH in aqueous THF at room temperture and purified to give the biphenyl trans-hydroxy indolizine.

Step 2: Detritylation of trityl tetrazole

A solution of the trityl protected biphenyl trans-hydroxy indolizine (0.079 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 1943.

EXAMPLE 1944 ##STR123## 1- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-8-yl!-2,5-pyrrolidinedione

Step 1: Preparation of succinimidyl indolizine

To a solution of biphenyl indolizine (3.13 mmol, Example 1938, Step 3) and 1.25 g (12.6 mmol) of succinimide in 20 mL of anhydrous acetonitrile is added 572 mg (3.21 mmol) of NBS in one portion. The resulting orange-red solution is stirred at room temperature for 30 min, then evaporated in vacuo. The residue is dissolved in ethyl acetate and washed with aqueous sodium bisulfite, water,and brine. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl indolizine.

Alternatively, the succinimide can be prepared from its corresponding hydroxy indolizine. To a solution of the biphenyl hydroxy indolizine (2.0 mmol, obtained from Step 1 of Example 1942 or 1943), succinimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl indolizine.

Step 2: Detritylation of trityl tetrazole

A solution of trityl protected succinimidyl indolizine (0.16 mmol, obtained from Step 1) in 0.2 mL of water and 1 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938 and purified to give the title compound of Example 1944.

EXAMPLE 1945 ##STR124## 4- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-8-yl!amino!-4-oxobutanoic acid, hydrazide

A solution of succinimidyl indolizine (0.06 mmol, obtained from Example 1944) and 11 μL (5.6 mmol) of hydrazine in 0.5 mL of ethanol is stirred at room temperature until the reaction is complete and concentrated in vacuo to give the title compound of Example 1945.

EXAMPLE 1946 ##STR125## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-5H-pyrrolo 1,5-a!azepine

Step 1: Alkylation of biphenyl pyrrole

To a solution of biphenyl pyrrole (0.152 mmol, obtained from Step 2 of Example 1938) in 0.8 mL of DME cooled at -45° C. (acetonitrile-dry ice) is added 125 μL (0.2 mmol) of n-butyllithium (1.6M in hexane) over a 4-min period. The resulting dark red solution is stirred cold for another 15 min, followed by addition of 70 μL (0.37 mmol) of 2-(3-bromopropyl)-5,5-dimethyl-1,3-dioxane in one portion. The mixture is stirred cold for 40 min, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo. The crude product can be used directly in the subsequent Step 2 without purification.

Step 2: Preparation of the indolizine

A solution of the crude mixture (0.152 mmol, obtained from Step 1) and 255 mg (3 mmol) of NaOAc in 0.6 mL of water and 2 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The mixture is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 130 mg (0.46 mmol) of trityl chloride and 0.22 mL (1.6 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl indolizine.

Step 3: Detritylation of trityl tetrazole

A solution of the biphenyl indolizine (0.035 mmol, obtained from Step 2) is stirred with 0.4 mL of water and 2 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938 and purified to give the title compound of Example 1946.

EXAMPLE 1947 ##STR126## 1,1-Dimethylethyl 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-8(5H)-indolizinylidene!acetate

Step 1: Preparation of tert-butyl ester

To a suspension of 64 mg (2.63 mmol) of magnesium in 3.0 mL of THF at 55° C. is added two 10-μL portions of 1,2-dibromoethane, 5 min apart. The resulting mixture is stirred at 45° C. for 10 min, followed by dropwise addition of a solution of biphenyl keto indolizine (0.306 mmol, obtained from Step 3 of Example 1940) and 242 μL (1.50 mmol) of tert-butyl bromoacetate in 2.0 mL of THF at 55° C. over a 1 h period. The resulting solution is stirred until the reaction is complete. The mixture is cooled and quenched with aqueous NH₄ Cl. The mixture is extracted with ether, dried (MgSO₄) and concentrated in vacuo. The crude mixture can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of unsaturated butyl ester

To a solution of the crude biphenyl tert-butyl ester intermediate (0.306 mmol, obtained from Step 1) and 200 μL (2.47 mmol) of pyridine in 2 mL of methylene chloride at 0° C. is added dropwise 80 μL (1.1 mmol) of thionyl chloride. The resulting dark brown solution is stirred at 0° C. for 1 h, diluted with water and extracted with methylene chloride. The residue is purified to give the biphenyl indolizinyl unsaturated ester.

Step 3: Detritylation of trityl tetrazole

A solution of biphenyl indolizinyl unsaturated ester (0.133 mmol, obtained from Step 2) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938 and purified to give the title compound of Example 1947.

EXAMPLE 1948 ##STR127## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-8(5H)-indolizinylidene!acetic acid

To a solution of unsaturated tert-butyl ester (0.0627 mmol, the title compound of Example 1947) in 2 mL of CDCl₃ at room temperature is added 0.5 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting yellow solution is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The crude product is purified to give the title compound of Example 1948.

EXAMPLE 1949 ##STR128## 1,1-Dimethylethyl 3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-8-acetate

Step 1: Preparation of deconjugated ester

To a solution of ester (0.237 mmol, obtained from Step 2 of Example 1947) in 4 mL of THF at 0° C. is added 310 μL of 1.5M (0.467 mmol) LDA over a 2-min period, and the resulting solution is stirred at 0° C. for 10 min. The mixture is cooled to -78° C., stirred cold for 5 min, and quenched dropwise at -78° C. with 100 μL of acetic acid in 1 mL of hexane. The mixture is stirred cold, then warmed to room temperature and treated with aqueous NaHCO₃. The mixture is extracted with methylene chloride. The combined extracts are washed with water, dried (MgSO₄) and concentrated in vacuo to give a crude mixture. The crude product is purified to give the biphenyl indolizinyl deconjugated ester.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl indolizinyl deconjugated ester (0.165 mmol, obtained from Step 1) in 1 mL of water and 3 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 1938. The crude product is purified to give the title compound of Example 1949.

EXAMPLE 1950 ##STR129## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-8-acetic acid

To a solution of biphenyl indolizinyl tert-butyl ester (0.039 mmol, the title compound of Example 1949) in 0.5 mL of chloroform is added 0.25 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is stirred at room temperature until the reaction is complete. The mixture is quenched with methanol and concentrated in vacuo. The residue is purified to give the title compound of Example 1950.

EXAMPLE 1951 ##STR130## 1,1-Dimethylethyl 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-cis-8-acetate

A suspension of the biphenyl indolizinyl unsaturated ester (0.059 mmol, the title compound of Example 1949) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under an atmosphere of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite and concentrated in vacuo. The residue is purified to give the title compound of Example 1951.

EXAMPLE 1952 ##STR131## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-cis-8-acetic acid

To a solution of tert-butyl ester (0.0332 mmol, obtained from Example 1951) in 0.4 mL of CDCl₃ is added 0.2 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is allowed to stand at room temperature until the reaction is complete. The reaction mixture is diluted with methanol and concentrated. The residue is purified to give the title compound of Example 1952.

EXAMPLE 1953 ##STR132## 3-Butyl-5,6-dihydro-N-hydroxy-5- 2'-(1H-tetrazol-5-yl) 1.1'-biphenyl!-4-yl!indolizin-8(7H)-imine

A mixture of biphenyl keto indolizine (0.094 mmol, the title compound of Example 1941), 20 mg (0.29 mmol) of N-hydroxyamine (hydrochloride salt) and 30 mg of NaOAc in 2 mL of methanol is stirred at 60° C. until the reaction is complete. The mixture is diluted with chloroform and filtered. The solid is washed with methanol. The filtrate is concentrated in vacuo and purified to give the title compound of Example 1953.

EXAMPLE 1954 ##STR133## 1- 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizin-8-yl!phthalimide

Step 1: Preparation of biphenyl phthalimidyl indolizine

To a solution of the biphenyl hydroxy indolizine (2.0 mmol, obtained from Step 1 of Example 1942 or 1943), phthalimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected phthalimidyl indolizine.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl phthalimidyl indolizine (2.0 mmol, obtained from Step 1) in 2 mL of water and 10 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 5 of Example 1938 and purified give the title compound of Example 1954.

EXAMPLE 1955 ##STR134## 3-Butyl-5,6,7,8-tetrahydro-8-amino-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!indolizine

A solution of phthalimidyl indolizine (0.6 mmol, the title compound of Example 1954) and 3 μL (1.5 mmol) of hydrazine in 1.0 mL of ethanol is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo, and purified to give the title compound of Example 1955.

Alternatively, the title compound of Example 1955 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, the title compound of Example 1953) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1955.

Examples 1956-3256 located in Tables XLIV-LXXII, are further examples of conformationally restricted angiotensin II antagonists embraced by Formula IV.

                  TABLE XLIX                                                       ______________________________________                                          ##STR135##                                                                    EX. #   R.sup.139   R.sup.140                                                                               R.sup.141                                         ______________________________________                                         1956    H           C.sub.3 H.sub.7 (n)                                                                     H                                                 1957    H           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   1958    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       1959    H           C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        1960    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               1961    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               1962    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     1963    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     1964    H           C.sub.3 H.sub.7 (n)                                                                     phenyl                                            1965    H           C.sub.3 H.sub.7 (n)                                                                     benzyl                                            1966    H           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   1967    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       1968    H           C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        1969    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     1970    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C                                                  (CH.sub.3).sub.3                                  1971    H           C.sub.4 H.sub.9 (n)                                                                     phenyl                                            1972    H           C.sub.4 H.sub.9 (n)                                                                     benzyl                                            1973    Cl          C.sub.3 H.sub.7 (n)                                                                     H                                                 1974    Cl          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   1975    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       1976    Cl          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        1977    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               1978    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               1979    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     1980    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     1981    Cl          C.sub.4 H.sub.9 (n)                                                                     H                                                 1982    Cl          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   1983    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       1984    Cl          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        1985    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               1986    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               1987    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     1988    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     1989    ethyl       C.sub.3 H.sub.7 (n)                                                                     H                                                 1990    ethyl       C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   1991    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       1992    ethyl       C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        1993    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               1994    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               1995    ethyl       C.sub.4 H.sub.9 (n)                                                                     H                                                 1996    ethyl       C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   1997    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       1998    ethyl       C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        1999    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2000    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2001    n-butyl     C.sub.3 H.sub.7 (n)                                                                     H                                                 2002    n-butyl     C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2003    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2004    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2005    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2006    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2007    n-butyl     C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2008    n-butyl     C.sub.4 H.sub.9 (n)                                                                     H                                                 2009    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2010    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2011    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2012    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2013    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H                                                 2014    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2015    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2016    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2017    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2018    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2019    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H                                                 2020    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2021    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2022    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2023    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2024    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               ______________________________________                                    

                  TABLE L                                                          ______________________________________                                          ##STR136##                                                                    EX. #   R.sup.142    R.sup.143 R.sup.144                                       ______________________________________                                         2025    H            C.sub.3 H.sub.7 (n)                                                                      O                                               2026    H            C.sub.3 H.sub.7 (n)                                                                      S                                               2027    H            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2028    H            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2029    H            C.sub.3 H.sub.7 (n)                                                                      NOH                                             2030    H            C.sub.4 H.sub.9 (n)                                                                      S                                               2031    Cl           C.sub.3 H.sub.7 (n)                                                                      O                                               2032    Cl           C.sub.3 H.sub.7 (n)                                                                      S                                               2033    Cl           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2034    Cl           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2035    Cl           C.sub.3 H.sub.7 (n)                                                                      NOH                                             2036    Cl           C.sub.4 H.sub.9 (n)                                                                      O                                               2037    Cl           C.sub.4 H.sub.9 (n)                                                                      S                                               2038    Cl           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2039    Cl           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2040    Cl           C.sub.4 H.sub.9 (n)                                                                      NOH                                             2041    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      O                                               2042    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      S                                               2043    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2044    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2045    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      NOH                                             2046    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      O                                               2047    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      S                                               2048    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2049    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2050    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      NOH                                             2051    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      O                                               2052    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      S                                               2053    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2054    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2055    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      NOH                                             2056    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      O                                               2057    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      S                                               2058    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2059    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2060    C.sub.4 H.sub.9 (n                                                                          C.sub.4 H.sub.9 (n)                                                                      NOH                                             2061    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      O                                               2062    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      S                                               2063    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2064    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      NOH                                             2065    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      O                                               2066    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      S                                               2067    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2068    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      NOH                                             ______________________________________                                    

                  TABLE LI                                                         ______________________________________                                          ##STR137##                                                                    EX. #     R.sup.145     R.sup.146 R.sup.147                                    ______________________________________                                         2069      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2070      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2071      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2072      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2073      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2074      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2075      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2076      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2077      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2078      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2079      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2080      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2081      C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2082      C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2083      (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2084      (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              ______________________________________                                    

                  TABLE LII                                                        ______________________________________                                          ##STR138##                                                                    EX. #    R.sup.148    R.sup.149 R.sup.150                                      ______________________________________                                         2085     H            C.sub.3 H.sub.7 (n)                                                                      H                                              2086     H            C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2087     H            C.sub.3 H.sub.7 (n)                                                                      OH                                             2088     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2089     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2090     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2091     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2092     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2093     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2094     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2095     H            C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2096     H            C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2097     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2098     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2099     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2100     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2101     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2102     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                2103     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2104     H            C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                2105     H            C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2106     Cl           C.sub.3 H.sub.7 (n)                                                                      H                                              2107     Cl           C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2108     Cl           C.sub.3 H.sub.7 (n)                                                                      OH                                             2109     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2110     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2111     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2112     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2113     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2114     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2115     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2116     Cl           C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2117     Cl           C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2118     Cl           C.sub.4 H.sub.9 (n)                                                                      H                                              2119     Cl           C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2120     Cl           C.sub.4 H.sub.9 (n)                                                                      OH                                             2121     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2122     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2123     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2124     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2125     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2126     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                2127     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2128     Cl           C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                2129     Cl           C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2130     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              2131     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2132     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             2133     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2134     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2135     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2136     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2137     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2138     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              2139     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2140     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             2141     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2142     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2143     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2144     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2145     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2146     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      H                                              2147     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2148     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      OH                                             2149     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2150     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2151     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2152     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2153     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2154     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      H                                              2155     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2156     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      OH                                             2157     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2158     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2159     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2160     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2161     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              2162     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2163     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             2164     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2165     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2166     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2167     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2168     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              2169     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2170     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             2171     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2172     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2173     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2174     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE LIII                                                       ______________________________________                                          ##STR139##                                                                    EX. # R.sup.151   R.sup.152                                                                               R.sup.153                                                                              R.sup.154                                   ______________________________________                                         2175  H           C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2176  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2177  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2178  H           C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2179  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2180  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2181  Cl          C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2182  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2183  Cl          C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5 CH.sub.2                                                               CH.sub.3                                    2184  Cl          C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2185  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2186  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2187  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2188  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2189  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2190  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2191  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2192  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2193  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2194  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2195  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2196  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2197  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2198  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2199  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2200  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2201  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2202  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2203  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2204  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2205  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2206  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2207  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2208  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2209  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2210  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2211  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2212  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2213  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2214  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2215  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2216  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2217  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2218  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2219  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2220  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2221  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2222  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2223  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2224  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2225  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2226  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2227  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2228  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2229  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2230  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                2231  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2232  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                2233  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2234  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                ______________________________________                                    

                  TABLE LIV                                                        ______________________________________                                          ##STR140##                                                                    EX. #     R.sup.155    R.sup.156  R.sup.157,R.sup.158                          ______________________________________                                         2235      H            C.sub.3 H.sub.7 (n)                                                                       O                                            2236      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          2237      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2238      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2239      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2240      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2241      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          2242      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2243      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2244      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2245      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2246      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            2247      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          2248      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2249      Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2250      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2251      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2252      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            2253      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          2254      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2255      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2256      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2257      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2258      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2259      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2260      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2261      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2262      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2263      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2264      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2265      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2266      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2267      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2268      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2269      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2270      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            2271      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          2272      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2273      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2274      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2275      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            2276      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          2277      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2278      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2279      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2280      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2281      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2282      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2283      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            2284      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2285      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2286      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2287      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2288      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2289      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            2290      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2291      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE LV                                                         ______________________________________                                          ##STR141##                                                                    EX. #     R.sup.159    R.sup.160  R.sup.161,R.sup.162                          ______________________________________                                         2292      H            C.sub.3 H.sub.7 (n)                                                                       O                                            2293      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          2294      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2295      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2296      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2297      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2298      H            C.sub.4 H.sub.9 (n)                                                                       O                                            2299      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          2300      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2301      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2302      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2303      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2304      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            2305      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          2306      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2307      Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2308      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2309      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2310      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            2311      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          2312      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2313      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2314      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2315      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2316      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2317      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2318      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2319      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2320      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2321      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2322      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2323      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2324      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2325      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2326      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2327      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2328      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            2329      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          2330      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2331      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2332      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2333      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            2334      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          2335      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2336      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2337      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2338      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2339      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2340      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2341      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            2342      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2343      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2344      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2345      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2346      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   ______________________________________                                    

                  TABLE LVI                                                        ______________________________________                                          ##STR142##                                                                    EX. #   R.sup.163    R.sup.164                                                                               R.sup.165                                        ______________________________________                                         2347    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.3,CH.sub.3                                2348    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     H,CH.sub.2 OH                                    2349    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     H,CO.sub.2 H                                     2350    H            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2351    H            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              2352    H            C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2353    H            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2354    H            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2355    H            C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2356    H            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              2357    H            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2358    H            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2359    H            C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2360    Cl           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2361    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              2362    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2363    Cl           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2364    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2365    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2366    Cl           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2367    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              2368    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2369    Cl           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2370    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2371    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2372    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2373    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2374    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2375    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2376    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2377    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2378    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2379    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2380    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2381    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2382    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2383    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                ______________________________________                                    

                  TABLE LVII                                                       ______________________________________                                          ##STR143##                                                                    EX. #   R.sup.166   R.sup.167                                                                               R.sup.168                                         ______________________________________                                         2384    H           C.sub.3 H.sub.7 (n)                                                                     H                                                 2385    H           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2386    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2387    H           C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2388    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2389    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2390    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2391    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2392    H           C.sub.3 H.sub.7 (n)                                                                     phenyl                                            2393    H           C.sub.3 H.sub.7 (n)                                                                     benzyl                                            2394    H           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2395    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2396    H           C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2397    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2398    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2399    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2400    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2401    H           C.sub.4 H.sub.9 (n)                                                                     phenyl                                            2402    H           C.sub.4 H.sub.9 (n)                                                                     benzyl                                            2403    Cl          C.sub.3 H.sub.7 (n)                                                                     H                                                 2404    Cl          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2405    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2406    Cl          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2407    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2408    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2409    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2410    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2411    Cl          C.sub.4 H.sub.9 (n)                                                                     H                                                 2412    Cl          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2413    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2414    Cl          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2415    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2416    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2417    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2418    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2419    ethyl       C.sub.3 H.sub.7 (n)                                                                     H                                                 2420    ethyl       C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2421    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2422    ethyl       C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2423    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2424    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2425    ethyl       C.sub.4 H.sub.9 (n)                                                                     H                                                 2426    ethyl       C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2427    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2428    ethyl       C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2429    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2430    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2431    n-butyl     C.sub.3 H.sub.7 (n)                                                                     H                                                 2432    n-butyl     C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2433    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2434    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2435    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2436    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2437    n-butyl     C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2438    n-butyl     C.sub.4 H.sub.9 (n)                                                                     H                                                 2439    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2440    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2441    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2442    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2443    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H                                                 2444    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2445    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2446    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2447    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2448    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2449    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H                                                 2450    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2451    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2452    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2453    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2454    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               ______________________________________                                    

                  TABLE LVIII                                                      ______________________________________                                          ##STR144##                                                                    EX. #   R.sup.169    R.sup.170 R.sup.171                                       ______________________________________                                         2455    H            C.sub.3 H.sub.7 (n)                                                                      O                                               2456    H            C.sub.3 H.sub.7 (n)                                                                      S                                               2457    H            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2458    H            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2459    H            C.sub.3 H.sub.7 (n)                                                                      NOH                                             2460    H            C.sub.4 H.sub.9 (n)                                                                      O                                               2461    H            C.sub.4 H.sub.9 (n)                                                                      S                                               2462    H            C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2463    H            C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2464    Cl           C.sub.3 H.sub.7 (n)                                                                      O                                               2465    Cl           C.sub.3 H.sub.7 (n)                                                                      S                                               2466    Cl           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2467    Cl           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2468    Cl           C.sub.3 H.sub.7 (n)                                                                      NOH                                             2469    Cl           C.sub.4 H.sub.9 (n)                                                                      O                                               2470    Cl           C.sub.4 H.sub.9 (n)                                                                      S                                               2471    Cl           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2472    Cl           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2473    Cl           C.sub.4 H.sub.9 (n)                                                                      NOH                                             2474    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      O                                               2475    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      S                                               2476    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2477    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2478    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      NOH                                             2479    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      O                                               2480    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      S                                               2481    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2482    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2483    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      NOH                                             2484    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      O                                               2485    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      S                                               2486    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2487    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2488    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      NOH                                             2489    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      O                                               2490    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      S                                               2491    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2492    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2493    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      NOH                                             2494    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      O                                               2495    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      S                                               2496    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2497    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      NOH                                             2498    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      O                                               2499    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      S                                               2500    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2501    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      NOH                                             ______________________________________                                    

                  TABLE LIX                                                        ______________________________________                                          ##STR145##                                                                    EX. #     R.sup.172     R.sup.173 R.sup.174                                    ______________________________________                                         2502      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2503      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2504      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2505      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2506      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2507      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2508      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2509      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2510      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2511      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2512      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2513      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2514      C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2515      C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                    2516      (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2517      (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              ______________________________________                                    

                  TABLE LX                                                         ______________________________________                                          ##STR146##                                                                    EX. #    R.sup.175    R.sup.176 R.sup.177                                      ______________________________________                                         2518     H            C.sub.3 H.sub.7 (n)                                                                      H                                              2519     H            C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2520     H            C.sub.3 H.sub.7 (n)                                                                      OH                                             2521     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2522     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2523     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2524     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2525     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2526     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2527     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2528     H            C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2529     H            C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2530     H            C.sub.3 H.sub.7 (n)                                                                      H                                              2531     H            C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2532     H            C.sub.3 H.sub.7 (n)                                                                      OH                                             2533     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2534     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2535     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2536     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2537     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2538     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                2539     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2540     H            C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                2541     H            C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2542     Cl           C.sub.4 H.sub.9 (n)                                                                      H                                              2543     Cl           C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2544     Cl           C.sub.3 H.sub.7 (n)                                                                      OH                                             2545     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2546     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2547     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2548     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2549     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2550     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2551     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2552     Cl           C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2553     Cl           C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2554     Cl           C.sub.4 H.sub.9 (n)                                                                      H                                              2555     Cl           C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2556     Cl           C.sub.4 H.sub.9 (n)                                                                      OH                                             2557     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2558     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2559     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2560     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2561     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2562     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                2563     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2564     Cl           C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                2565     Cl           C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2566     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              2567     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2568     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             2569     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2570     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2571     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2572     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2573     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              2574     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2575     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             2576     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2577     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2578     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2579     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2580     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      H                                              2581     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2582     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      OH                                             2583     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2584     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2585     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2586     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2587     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2588     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      H                                              2589     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2590     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      OH                                             2591     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2592     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2593     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2594     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2595     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              2596     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2597     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             2598     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2599     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2600     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2601     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2602     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              2603     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2604     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             2605     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2606     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2607     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2608     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE LXI                                                        ______________________________________                                          ##STR147##                                                                    EX. # R.sup.178   R.sup.179                                                                               R.sup.180                                                                              R.sup.181                                   ______________________________________                                         2609  H           C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2610  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2611  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2612  H           C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2613  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2614  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2615  Cl          C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2616  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2617  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2618  Cl          C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2619  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2620  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    2621  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2622  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2623  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2624  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2625  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2626  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2627  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2628  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2629  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    2630  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2631  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    2632  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    2633  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2634  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2635  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2636  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2637  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2638  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2639  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2640  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2641  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2642  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2643  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2644  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             2645  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             2646  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             2647  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2648  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2649  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2650  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2651  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2652  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2653  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2654  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2655  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2656  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2657  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2658  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2659  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             2660  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2661  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             2662  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             2663  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2664  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                2665  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2666  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                2667  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                2668  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                ______________________________________                                    

                  TABLE LXII                                                       ______________________________________                                          ##STR148##                                                                    EX. #     R.sup.182    R.sup.183  R.sup.184,R.sup.185                          ______________________________________                                         2669      H            C.sub.3 H.sub.7 (n)                                                                       O                                            2670      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          2671      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2672      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2673      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2674      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2675      H            C.sub.4 H.sub.9 (n)                                                                       O                                            2676      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          2677      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2678      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2679      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2680      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2681      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            2682      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          2683      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2684      Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2685      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2686      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2687      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            2688      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          2689      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2690      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2691      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2692      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2693      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2694      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2695      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2696      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2697      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2698      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2699      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2700      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2701      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2702      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2703      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2704      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2705      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            2706      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          2707      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2708      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2709      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2710      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            2711      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          2712      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2713      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2714      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2715      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2716      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2717      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2718      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            2719      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2720      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2721      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2722      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2723      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2724      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            2725      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2726      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE LXIII                                                      ______________________________________                                          ##STR149##                                                                    EX. #     R.sup.186    R.sup.187  R.sup.188,R.sup.189                          ______________________________________                                         2727      H            C.sub.3 H.sub.7 (n)                                                                       O                                            2728      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          2729      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2730      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2731      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2732      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2733      H            C.sub.4 H.sub.9 (n)                                                                       O                                            2734      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          2735      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2736      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2737      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2738      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2739      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            2740      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          2741      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2742      Cl           C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            2743      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2744      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2745      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            2746      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          2747      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2748      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2749      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2750      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2751      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2752      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2753      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2754      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            2755      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2756      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2757      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2758      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2759      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2760      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            2761      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2762      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2763      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            2764      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          2765      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2766      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2767      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2768      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            2769      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          2770      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2771      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2772      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 2773      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            2774      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          2775      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   2776      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            2777      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                2778      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 2779      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            2780      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          2781      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   2782      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            2783      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                2784      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE LXIV                                                       ______________________________________                                          ##STR150##                                                                    EX. #   R.sup.190    R.sup.191                                                                               R.sup.192                                        ______________________________________                                         2785    H            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2786    H            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              2787    H            C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2788    H            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2789    H            C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2790    H            C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2791    H            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2792    H            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              2793    H            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2794    H            C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2795    H            C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2796    Cl           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2797    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              2798    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2799    Cl           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2800    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2801    Cl           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2802    Cl           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2803    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              2804    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     2805    Cl           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2806    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      2807    Cl           C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             2808    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2809    C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2810    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2811    C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2812    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2813    C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2814    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2815    C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                2816    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         2817    (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                2818    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         2819    (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                ______________________________________                                    

                  TABLE LXV                                                        ______________________________________                                          ##STR151##                                                                    EX. #   R.sup.193   R.sup.194                                                                               R.sup.195                                         ______________________________________                                         2820    H           C.sub.3 H.sub.7 (n)                                                                     H                                                 2821    H           C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2822    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2823    H           C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2824    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2825    H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2826    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2827    H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2828    H           C.sub.3 H.sub.7 (n)                                                                     phenyl                                            2829    H           C.sub.3 H.sub.7 (n)                                                                     benzyl                                            2830    H           C.sub.4 H.sub.9 (n)                                                                     H                                                 2831    H           C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2832    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2833    H           C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2834    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2835    H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2836    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2837    H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2838    H           C.sub.4 H.sub.9 (n)                                                                     phenyl                                            2839    H           C.sub.4 H.sub.9 (n)                                                                     benzyl                                            2840    Cl          C.sub.3 H.sub.7 (n)                                                                     H                                                 2841    Cl          C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2842    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2843    Cl          C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2844    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2845    Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2846    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2847    Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2848    Cl          C.sub.4 H.sub.9 (n)                                                                     H                                                 2849    Cl          C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2850    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2851    Cl          C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2852    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2853    Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2854    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 H                     2855    Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CO.sub.2 C(CH.sub.3).sub.3     2856    ethyl       C.sub.3 H.sub.7 (n)                                                                     H                                                 2857    ethyl       C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2858    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2859    ethyl       C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2860    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2861    ethyl       C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2862    ethyl       C.sub.4 H.sub.9 (n)                                                                     H                                                 2863    ethyl       C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2864    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2865    ethyl       C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2866    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2867    ethyl       C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2868    n-butyl     C.sub.3 H.sub.7 (n)                                                                     H                                                 2869    n-butyl     C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2870    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2871    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2872    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2873    n-butyl     C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2874    n-butyl     C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2875    n-butyl     C.sub.4 H.sub.9 (n)                                                                     H                                                 2876    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2877    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2878    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2879    n-butyl     C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2880    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H                                                 2881    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                   2882    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 OH                                       2883    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CO.sub.2 H                                        2884    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                               2885    (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               2886    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H                                                 2887    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     C.sub.2 H.sub.5                                   2888    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 OH                                       2889    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CO.sub.2 H                                        2890    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 H                               2891    (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3               ______________________________________                                    

                  TABLE LXVI                                                       ______________________________________                                          ##STR152##                                                                    EX. #    R.sup.196   R.sup.197 R.sup.198                                       ______________________________________                                         2892     H           C.sub.3 H.sub.7 (n)                                                                      O                                               2893     H           C.sub.3 H.sub.7 (n)                                                                      S                                               2894     H           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2895     H           C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2896     H           C.sub.3 H.sub.7 (n)                                                                      NOH                                             2897     H           C.sub.4 H.sub.9 (n)                                                                      O                                               2898     H           C.sub.4 H.sub.9 (n)                                                                      S                                               2899     H           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2900     H           C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2901     Cl          C.sub.3 H.sub.7 (n)                                                                      O                                               2902     Cl          C.sub.3 H.sub.7 (n)                                                                      S                                               2903     Cl          C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2904     Cl          C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2905     Cl          C.sub.3 H.sub.7 (n)                                                                      NOH                                             2906     Cl          C.sub.4 H.sub.9 (n)                                                                      O                                               2907     Cl          C.sub.4 H.sub.9 (n)                                                                      S                                               2908     Cl          C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2909     Cl          C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2910     Cl          C.sub.4 H.sub.9 (n)                                                                      NOH                                             2911     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                      O                                               2912     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                      S                                               2913     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2914     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2915     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                      NOH                                             2916     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                      O                                               2917     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                      S                                               2918     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2919     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2920     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                      NOH                                             2921     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                      O                                               2922     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                      S                                               2923     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2924     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2925     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                      NOH                                             2926     C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                      O                                               2927     C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                      S                                               2928     C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2929     C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 C(CH.sub.3).sub.3                    2930     C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                      NOH                                             2931     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                      O                                               2932     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                      S                                               2933     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                      CHCO.sub.2 H                                    2934     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                      NOH                                             2935     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                      O                                               2936     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                      S                                               2937     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                      CHCO.sub.2 H                                    2938     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                      NOH                                             ______________________________________                                    

                  TABLE LXVII                                                      ______________________________________                                          ##STR153##                                                                    EX. #     R.sup.199     R.sup.200 R.sup.201                                    ______________________________________                                         2939      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2940      H             C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2941      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2942      H             C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2943      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2944      Cl            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2945      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2946      Cl            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2947      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2948      C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                          2949      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2950      C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                          2951      C.sub.4 H.sub.9 (n)                                                                          C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2952      C.sub.4 H.sub.9 (n)                                                                          C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              2953      (2-ethylphenyl)                                                                              C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                              2954      (2-ethylphenyl)                                                                              C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                              ______________________________________                                    

                  TABLE LXVIII                                                     ______________________________________                                          ##STR154##                                                                    EX. #    R.sup.202    R.sup.203 R.sup.204                                      ______________________________________                                         2955     H            C.sub.3 H.sub.7 (n)                                                                      H                                              2956     H            C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2957     H            C.sub.3 H.sub.7 (n)                                                                      OH                                             2958     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2959     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2960     H            C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2961     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2962     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2963     H            C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2964     H            C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2965     H            C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2966     H            C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2967     H            C.sub.3 H.sub.7 (n)                                                                      H                                              2968     H            C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       2969     H            C.sub.3 H.sub.7 (n)                                                                      OH                                             2970     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2971     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2972     H            C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2973     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2974     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2975     H            C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                2976     H            C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2977     H            C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                2978     H            C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            2979     Cl           C.sub.4 H.sub.9 (n)                                                                      H                                              2980     Cl           C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2981     Cl           C.sub.3 H.sub.7 (n)                                                                      OH                                             2982     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    2983     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     2984     Cl           C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2985     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                2986     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                            2987     Cl           C.sub.3 H.sub.7 (n)                                                                      C.sub.6 H.sub.5                                2988     Cl           C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       2989     Cl           C.sub.3 H.sub.7 (n)                                                                      (2-ethylphenyl)                                2990     Cl           C.sub.3 H.sub.7 (n)                                                                      OCH.sub.2 C.sub.6 H                            2991     Cl           C.sub.4 H.sub.9 (n)                                                                      H                                              2992     Cl           C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       2993     Cl           C.sub.4 H.sub.9 (n)                                                                      OH                                             2994     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    2995     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     2996     Cl           C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     2997     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                2998     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                            2999     Cl           C.sub.4 H.sub.9 (n)                                                                      C.sub.6 H.sub.5                                3000     Cl           C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       3001     Cl           C.sub.4 H.sub.9 (n)                                                                      (2-ethylphenyl)                                3002     Cl           C.sub.4 H.sub.9 (n)                                                                      OCH.sub.2 C.sub.6 H                            3003     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              3004     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       3005     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             3006     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    3007     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     3008     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3009     C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                3010     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              3011     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       3012     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             3013     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    3014     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     3015     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3016     C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                3017     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      H                                              3018     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       3019     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      OH                                             3020     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    3021     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     3022     C.sub.4 H.sub.9                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3023     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                3024     C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                       3025     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      H                                              3026     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       3027     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      OH                                             3028     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    3029     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     3030     C.sub.4 H.sub.9                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3031     C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                3032     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      H                                              3033     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      NH.sub.2                                       3034     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      OH                                             3035     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 OH                                    3036     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 H                                     3037     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3038     (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                3039     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      H                                              3040     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      NH.sub.2                                       3041     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      OH                                             3042     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 OH                                    3043     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 H                                     3044     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      CO.sub.2 C(CH.sub.3).sub.3                     3045     (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                ______________________________________                                    

                  TABLE LXIX                                                       ______________________________________                                          ##STR155##                                                                    EX. # R.sup.205   R.sup.206                                                                               R.sup.207                                                                              R.sup.208                                   ______________________________________                                         3046  H           C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    3047  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3048  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    3049  H           C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    3050  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3051  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    3052  Cl          C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    3053  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3054  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    3055  Cl          C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    3056  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3057  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                                                               CH.sub.3                                    3058  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    3059  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3060  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    3061  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3062  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    3063  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3064  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    3065  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3066  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.3                                    3067  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3068  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.3                                    3069  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.3                                    3070  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             3071  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3072  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             3073  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3074  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             3075  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3076  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             3077  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3078  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             3079  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3080  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             3081  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.2 H.sub.5                             3082  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.2 H.sub.5                             3083  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.2 H.sub.5                             3084  H           C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             3085  H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3086  H           C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             3087  H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3088  Cl          C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             3089  Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3090  Cl          C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             3091  Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3092  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             3093  C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3094  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             3095  C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3096  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     H       C.sub.6 H.sub.5                             3097  C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3098  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       C.sub.6 H.sub.5                             3099  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               C.sub.6 H.sub.5                             3100  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                3101  C.sub.4 H.sub.9 (n)                                                                        C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                3102  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                3103  (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                3104  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     H       CH.sub.2 CH.sub.2 CO.sub.2 H                3105  (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 H                ______________________________________                                    

                  TABLE LXX                                                        ______________________________________                                          ##STR156##                                                                    EX. #     R.sup.209    R.sup.210  R.sup.211,R.sup.212                          ______________________________________                                         3106      H            C.sub.3 H.sub.7 (n)                                                                       O                                            3107      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          3108      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3109      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            3110      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3111      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3112      H            C.sub.4 H.sub.9 (n)                                                                       O                                            3113      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          3114      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3115      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3116      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3117      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3118      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            3119      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          3120      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3121      Cl           C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            3122      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3123      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3124      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            3125      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          3126      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3127      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3128      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3129      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3130      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            3131      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          3132      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3133      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            3134      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3135      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3136      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            3137      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          3138      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3139      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3140      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3141      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3142      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            3143      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          3144      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3145      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3146      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3147      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            3148      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          3149      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3150      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3151      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3152      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            3153      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          3154      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3155      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            3156      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3157      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3158      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            3159      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          3160      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3161      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            3162      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3163      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE LXXI                                                       ______________________________________                                          ##STR157##                                                                    EX. #     R.sup.213    R.sup.214  R.sup.215,R.sup.216                          ______________________________________                                         3164      H            C.sub.3 H.sub.7 (n)                                                                       O                                            3165      H            C.sub.3 H.sub.7 (n)                                                                       H,H                                          3166      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3167      H            C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            3168      H            C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3169      H            C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3170      H            C.sub.4 H.sub.9 (n)                                                                       O                                            3171      H            C.sub.4 H.sub.9 (n)                                                                       H,H                                          3172      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3173      H            C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3174      H            C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3175      H            C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3176      Cl           C.sub.3 H.sub.7 (n)                                                                       O                                            3177      Cl           C.sub.3 H.sub.7 (n)                                                                       H,H                                          3178      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3179      Cl           C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            3180      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3181      Cl           C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3182      Cl           C.sub.4 H.sub.9 (n)                                                                       O                                            3183      Cl           C.sub.4 H.sub.9 (n)                                                                       H,H                                          3184      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3185      Cl           C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3186      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3187      Cl           C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3188      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            3189      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          3190      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3191      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,C.sub.2 H.sub.5                            3192      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3193      C.sub.2 H.sub.5                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3194      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            3195      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          3196      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3197      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,C.sub.2 H.sub.5                            3198      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3199      C.sub.2 H.sub.5                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3200      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       O                                            3201      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,H                                          3202      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3203      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3204      C.sub.4 H.sub.9 (n)                                                                         C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3205      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       O                                            3206      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,H                                          3207      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3208      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3209      C.sub.4 H.sub.9 (n)                                                                         C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 3210      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       O                                            3211      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,H                                          3212      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.3                                   3213      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       CH.sub.3,CH.sub.3                            3214      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CH.sub.2 OH                                3215      (2-ethylphenyl)                                                                             C.sub.3 H.sub.7 (n)                                                                       H,CO.sub.2 H                                 3216      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       O                                            3217      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,H                                          3218      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.3                                   3219      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       CH.sub.3,CH.sub.3                            3220      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CH.sub.2 OH                                3221      (2-ethylphenyl)                                                                             C.sub.4 H.sub.9 (n)                                                                       H,CO.sub.2 H                                 ______________________________________                                    

                  TABLE LXXII                                                      ______________________________________                                          ##STR158##                                                                    EX. #    R.sup.217   R.sup.218                                                                               R.sup.219                                        ______________________________________                                         3222     H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         3223     H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              3224     H           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     3225     H           C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                3226     H           C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      3227     H           C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             3228     H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         3229     H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)                              3230     H           C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                3231     H           C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      3232     H           C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             3233     Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         3234     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)                              3235     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     3236     Cl          C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                3237     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      3238     Cl          C.sub.3 H.sub.7 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             3239     Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         3240     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2l H.sub.5)                             3241     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)                     3242     Cl          C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                3243     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(C.sub.2 H.sub.5)CH.sub.2                      3244     Cl          C.sub.4 H.sub.9 (n)                                                                     CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2             3245     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         3246     C.sub.2 H.sub.5                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                3247     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         3248     C.sub.2 H.sub.5                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                3249     C.sub.4 H.sub.9                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         3250     C.sub.4 H.sub.9                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                3251     C.sub.4 H.sub.9                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         3252     C.sub.4 H.sub.9                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                3253     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2                                         3254     (2-ethylphenyl)                                                                            C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2                                3255     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2                                         3256     (2-ethylphenyl)                                                                            C.sub.4 H.sub.9 (n)                                                                     CH.sub.2 CH.sub.2                                ______________________________________                                    

An appropriately substituted triazole 91, the heterocyclic starting material, may be prepared as described in the literature E. C. Taylor in "Triazoles: 1,2,4" Vol. 37 of the Chemistry of Heterocyclic Compounds. A. Weissberger Eds., Wiley-Interscience, New York, 1981!. The triazole 1 in N,N-dimethylformamide (DMF) is treated with base, such as potassium tert-butoxide, followed by addition of appropriate alkylating agent 92 to give the coupled product 93 (Scheme XIII). For compounds where X is a substituted phenyl group, several procedures have been published for the preparations of the alkylating agent 92 see references for compound 2!. ##STR159##

The coupled triazole 93 itself may be an angiotensin II receptor antagonist, but it may also be used as a key intermediate in the preparation of the compounds of the invention. Triazole 93 in THF (or DME) is treated with base (such as n-BuLi or LDA) at -78° C. (or -65° C.), followed by addition of an appropriate alkylating agent or other electrophiles 94 (the acetal shown in Scheme I may be other aldehyde masking group or equivalent, and LG is a leaving group such as halide, mesylate, triflate or tosylate). The resulting masked aldehyde 95 was stirred with NaOAc in aqueous acetic acid at reflux for a few days (1 to 5 days) to give one of the compounds of the invention, a cyclized triazole 96.

The triazole 96 may be used as an intermediate to prepare other substituted compounds with appropriate functional group transformations and preparations of some of those compounds are illustrated in Scheme XIV and XV (all of the intermediates shown in the sequences are also angiotensin II receptor antagonists). For example, The unsaturated triazole 96, NaHCO₃ and NBS in CCl₄ is stirred at reflux to give a bromide 97. The triazole 96 may be hydrogenated to give its saturated product 99. ##STR160##

Alternatively, as illustrated in Scheme XV, the unsaturated triazole 96 may be treated with NBS in wet DMSO to give a bromohydrin which may be reduced with nBu₃ SnH to an alcohol 100 and the oxidation of the alcohol with MnO₂ will afford a ketone 101. The ketone 101 may be condensed with appropriately substituted amine, then reduced to an amine 102 with an appropriate reducing agent (e.g. NaBH₄, or hydrogen over catalyst). The amine 102 may also be prepared directly from olefin 96 under bromination condition (NBS, CH₃ CN) with a large excess of succinimide. The amine 102 may be used to prepare other derivatives. Alternatively, the alcohol 100 may be treated with triphenylphosphine, diethoxyazo dicarboxylate and an imide (e.g. phthalimide) to give an imide analogue which may be converted to an amine 102.

The ketone 101 may be treated with appropriate organometallic reagents (such as Grignard, organolithium, organocerium, organozinc reagents or related reagents) to give the addition product, a tertiary alcohol a) T. Imamoto; T. Kusumoto; Y. Tawarayama; Y. Sugiura; T. Mita; Y. Hatanaka; M. Yokoyama, J. Org. Chem., 49, 3904-3912 (1984). b) D. Bonneville, J. Org. Chem., 462 (1941). c) T. Hirao; D. Misu; K. Yao; T. Agawa, Tetrahedron Letter, 27, 929-932 (1986)!. The alcohol may be dehydrated to give an olefin 13 or an isomeric mixture of olefins 103. The olefin 103 may be treated with base, such as LDA and kinetically quenched at low temperature with either organic acid or appropriate electrophile at low temperature to give the isomerized olefin 104. The olefins 103 or 104 may be hydrogenated to its saturated analogue 105. Alternatively, olefin 104 can be prepared from ketone 101 by treatment with an appropriate organometallic reagent, such as a Grignard reagent. ##STR161##

In Scheme XVI, an alternative preparation for the compounds of the invention is described. An appropriately substituted triazole 91 may be treated with one equivalent of base, then protected as SEM or BOC derivative. The protected triazole then is treated with another equivalent of base followed by addition of electrophile 107 or 108. Electrophiles 107 and 108 can be prepared from HC(═O)(CR⁴ R⁵)(CH₂)_(n) C(═O)LG and an appropriate organometallic reagent such as XC₆ H₄ MgBr. If necessary, the resulting lithium anion obtained from the procedure described above may be converted to other organometallic reagents according to well-established procedures.

If PLG is a hydroxyl group and Z is a proton, the resulting addition product 109, may be cyclized with triphenylphosphine and diethyl azodicarboxylate Mitsunobu, O. Synthesis, 1981, 1-27; or other modified conditions!. If PLG is or is converted to a leaving group, such as halides, tosylate, and Z is a proton, the cyclization may be achieved with a weak base in DMF (e.g. K₂ CO₃, Cs₂ CO₃) to give a ketone 101. The ketone 101 may be reduced to an alcohol 100 with NaBH₄ in methanol. The alcohol 100 may be dehydrated to olefin 96 with acid (e.g. HOAc and heat or thionyl chloride and pyridine. Other compounds may be prepared from compounds 96, 100, or 101 as described in Scheme XIV and XV. ##STR162##

EXAMPLE 3257 ##STR163## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridine

Step 1: Preparation of biphenyl triazole

To a solution of 2-butylpyrrole (2.65 mmol) in 5.3 mL of DMF is added 3.45 mL (3.45 mmol) of potassium tert-butoxide (1M in THF), and the resulting solution is stirred at room temperature for 30 min. To the dark brown mixture is added 2.75 g (3.45 mmol) of the bromomethyl biphenyl. The reaction mixture is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl triazole.

Step 2: Preparation of dimethyl acetal triazole

To a solution of biphenyl triazole (3.18 mmol, obtained from Step 1) in 16 mL of THF cooled at -45° C. (acetonitrile-dry ice) is added 2.8 mL (4.06 mmol) of n-butyllithium (1.45M in hexane) over a 4-min period. The resulting dark purple solution is stirred cold for another 15 min, followed by addition of 1.0 mL (6.59 mmol) of 3-bromopropionaldehyde dimethyl acetal in one portion. The mixture is stirred cold for 40 min, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄), concentrated in vacuo and purified to give the biphenyl dimethyl acetal triazole intermediate.

Step 3: Preparation of biphenyl bicyclic triazole

A solution of the crude biphenyl dimethyl acetal triazole (3.18 mmol, obtained from Step 2) and 5.3 g (88 mmol) of NaOAc in 13 mL of water and 40 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The solution is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 2 g (7.2 mmol) of trityl chloride and 3 mL (21.5 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl bicyclic triazole.

Step 4: Detritylation of trityl tetrazole

A solution of the biphenyl bicyclic triazole (0.144 mmol, obtained from Step 3) is stirred with 1 mL of water and 6 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo, stirred in aqueous NaHCO₃ and washed with ether. The aqueous residue is acidified with 3N HCl to pH 4 and extracted with methylene chloride. The combined extracts are dried (MgSO₄), concentrated and purified to give the title compound of Example 3236.

EXAMPLE 3258 ##STR164## 7-Bromo-3-butyl -5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo4,3-a!pyridine

Step 1: Preparation of bromo olefin triazole

A solution of trityl-protected bicyclic triazole (0.101 mmol, obtained from Step 3 of Example 3257), 20 mg (0.112 mmol) of NBS and 7 mg (catalytic) of AIBN in 2.8 mL of CCl₄ is stirred at reflux until the reaction is complete. The reaction mixture is diluted with CCl₄ and washed with water. The organic layer is dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl bromo olefin triazole.

Step 2: Detritylation of the trityl tetrazole

A solution of bromo olefin triazole (0.0427 mmol, obtained from Step 1) in 0.8 mL of water and 5 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257 and purified to give the title compound of Example 3258.

EXAMPLE 3259 ##STR165## 3-Butyl -5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridine

A suspension of bicyclic olefin triazole 0.1 mmol, the title compound of Example 3257) and 20 mg (0.019 mmol) of 10% palladium on charcoal in 2 mL of absolute ethanol is agitated on a Parr apparatus under 50 psi of hydrogen gas at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 3259.

EXAMPLE 3260 ##STR166## 3-Butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8(5H)-one

Step 1: Preparation of the bromohydrin intermediate

To a solution of biphenyl olefin triazole (3.13 mmol, obtained from Step 4 of Example 3257) in 2.2 mL (0.122 mmol) of water and 22 mL of DMSO at room temperature is added 587 mg (3.30 mmol) of NBS in one portion. The resulting orange solution is stirred at room temperature for 40 min, quenched with aqueous Na₂ SO₃, and extracted with chloroform. The combined extracts are washed with water, and the combined aqueous layers are extracted with chloroform. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo to give a crude bromohydrin intermediate which can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of the trityl-protected biphenyl hydroxy triazole

To the crude bromohydrin (3.13 mmol, obtained from Step 1) in 42 mL of degassed dry benzene is added 4.3 mL (14.7 mmol) of n-Bu₃ SnH and 456 mg (2.7 mmol) of AIBN in one portion and the resulting solution is stirred at reflux until the reaction is complete. The mixture is concentrated in vacuo and partitioned between hexane and acetonitrile. The acetonitrile layer is washed with hexane, and the combined hexane layers are extracted with acetonitrile. The combined acetonitrile extracts are concentrated in vacuo to give an isomeric mixture of both cis- and trans-hydroxy triazoles (relative to the biphenyl moiety). The crude mixture can be used directly in subsequent Step 3 without further purification. The mixture may also be used to prepare the biphenyl trans-hydroxy triazole (the title compound of Example 3262).

Step 3: Preparation of the keto triazole

A suspension of the crude biphenyl hydroxy triazole (2.72 mmol, obtained from Step 2) and 13 g of active MnO₂ in 15 mL of methylene chloride is stirred at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl-protected biphenyl keto triazole.

Step 4: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl keto triazole (0.131 mmol, obtained from Step 3) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257 and purified to give the title compound of Example 3260.

EXAMPLE 3261 ##STR167## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-cis-8-ol

Step 1: Preparation of biphenyl cis-hydroxy triazole

To a solution of biphenyl keto triazole (0.456 mmol, obtained from Step 3 of Example 3260) in 0.5 mL of methanol and 2.0 mL of THF at 0° C. is added in small portions 34 mg (0.899 mmol) of NaBH₄. The resulting solution is stirred at 0° C., and slowly warmed to room temperature. The reaction is quenched with aqueous NH₄ Cl, extracted with methylene chloride, dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the biphenyl hydroxy triazole.

Step 2: Detritylation of trityl tetrazole

A solution of the biphenyl hydroxy triazole (0.259 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 3261.

EXAMPLE 3262 ##STR168## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-trans-8-ol

Step 1: Preparation of biphenyl trans-hydroxy triazole

A suspension of the crude biphenyl hydroxy triazole (1.307 mmol, obtained from Step 2 of Example 3260) and 3.0 g of active MnO₂ in 5.0 mL of methylene chloride is stirred at room temperature. The reaction is worked up before its completion. The mixture is filtered through a pad of celite, rinsed with IPA-methylene chloride, and concentrated in vacuo. The residue is purified to give the trityl protected biphenyl trans-hydroxy triazole.

Alternatively, the biphenyl trans-hydroxy triazole can be prepared using the Mitsunobu reaction conditions. To a solution of diethyl azodicarboxylate (2.0 mmol) and 3-nitrobenzoic acid (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of the biphenyl hydroxy triazole (2.0 mmol, obtained from Step 1 of Example 3261), and triphenylphosphine (2.0 mmol) in 1.0 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate, and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo to give the biphenyl indolizinyl nitrobenzoate. The crude benzoate is hydrolyzed with LiOH in aqueous THF at room temperture and purified to give the biphenyl trans-hydroxy triazole.

Step 2: Detritylation of trityl tetrazole

A solution of the trityl protected biphenyl trans-hydroxy triazole (0.079 mmol, obtained from Step 1) in 0.4 mL of water and 2.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the title compound of Example 3262.

EXAMPLE 3263 ##STR169## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8-yl!-2,5-pyrrolidinedione

Step 1: Preparation of succinimidyl triazole

To a solution of biphenyl triazole (3.13 mmol, Example 3257, Step 3) and 1.25 g (12.6 mmol) of succinimide in 20 mL of anhydrous acetonitrile is added 572 mg (3.21 mmol) of NBS in one portion. The resulting orange-red solution is stirred at room temperature for 30 min, then evaporated in vacuo. The residue is dissolved in ethyl acetate and washed with aqueous sodium bisulfite, water,and brine. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl triazole.

Alternatively, the succinimide can be prepared from its corresponding hydroxy triazole. To a solution of the biphenyl hydroxy triazole (2.0 mmol, obtained from Step 1 of Example 3261 or 3262), succinimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected succinimidyl triazole.

Step 2: Detritylation of trityl tetrazole

A solution of trityl protected succinimidyl triazole (0.16 mmol, obtained from Step 1) in 0.2 mL of water and 1 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257 and purified to give the title compound of Example 3263.

EXAMPLE 3264 ##STR170## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8-yl!amino!-4-oxobutanoic acid, hydrazide

A solution of succinimidyl triazole (0.06 mmol, obtained from Example 3263) and 11 μL (5.6 mmol) of hydrazine in 0.5 mL of ethanol is stirred at room temperature until the reaction is complete and concentrated in vacuo to give the title compound of Example 3264.

EXAMPLE 3265 ##STR171## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-5H, 2,4-triazolo 4,3-a!azepine

Step 1: Alkylation of biphenyl triazole

To a solution of biphenyl triazole (0.152 mmol, obtained from Step 2 of Example 3257) in 0.8 mL of DME cooled at -45° C. (acetonitrile-dry ice) is added 125 μL (0.2 mmol) of n-butyllithium (1.6M in hexane) over a 4-min period. The resulting dark red solution is stirred cold for another 15 min, followed by addition of 70 μL (0.37 mmol) of 2-(3-bromopropyl)-5,5-dimethyl-1,3-dioxane in one portion. The mixture is stirred cold for 40 min, then is slowly warmed to -10° C. The reaction is quenched with aqueous NH₄ Cl, extracted with diethyl ether. The combined extracts are washed with brine, dried (MgSO₄) and concentrated in vacuo. The crude product can be used directly in the subsequent Step 2 without purification.

Step 2: Preparation of the bicyclic triazole

A solution of the crude mixture (0.152 mmol, obtained from Step 1) and 255 mg (3 mmol) of NaOAc in 0.6 mL of water and 2 mL of glacial acetic acid is stirred at reflux until the reaction is complete. The mixture is cooled and concentrated in vacuo. The residue is dissolved in methylene chloride and filtered. The filtrate is stirred with 130 mg (0.46 mmol) of trityl chloride and 0.22 mL (1.6 mmol) of TEA at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is purified to give the biphenyl bicyclic triazole.

Step 3: Detritylation of trityl tetrazole

A solution of the biphenyl bicyclic triazole (0.035 mmol, obtained from Step 2) is stirred with 0.4 mL of water and 2 mL of acetic acid at room temperature until the reaction is complete. The solution is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257 and purified to give the title compound of Example 3265.

EXAMPLE 3266 ##STR172## 1,1-Dimethylethyl 3-butyl-6,7-dihydro-5- 2° -(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8(5H)-ylidene!acetate

Step 1: Preparation of tert-butyl ester

To a suspension of 64 mg (2.63 mmol) of magnesium in 3.0 mL of THF at 55° C. is added two 10-μL portions of 1,2-dibromoethane, 5 min apart. The resulting mixture is stirred at 45° C. for 10 min, followed by dropwise addition of a solution of biphenyl keto triazole (0.306 mmol, obtained from Step 3 of Example 3260) and 242 μL (1.50 mmol) of tert-butyl bromoacetate in 2.0 mL of THF at 55° C. over a 1-h period. The resulting solution is stirred until the reaction is complete. The mixture is cooled and quenched with aqueous NH₄ Cl. The mixture is extracted with ether, dried (MgSO₄) and concentrated in vacuo. The crude mixture can be used directly in the subsequent Step 2 without further purification.

Step 2: Preparation of unsaturated butyl ester

To a solution of the crude biphenyl tert-butyl ester intermediate (0.306 mmol, obtained from Step 1) and 200 μL (2.47 mmol) of pyridine in 2 mL of methylene chloride at 0° C. is added dropwise 80 μL (1.1 mmol) of thionyl chloride. The resulting dark brown solution is stirred at 0° C. for 1 h, diluted with water and extracted with methylene chloride. The residue is purified to give the biphenyl indolizinyl unsaturated ester.

Step 3: Detritylation of trityl tetrazole

A solution of biphenyl indolizinyl unsaturated ester (0.133 mmol, obtained from Step 2) in 1.0 mL of water and 5.0 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257 and purified to give the title compound of Example 3266.

EXAMPLE 3267 ##STR173## 3-Butyl-6,7-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8(5H)-ylidene!acetic acid

To a solution of unsaturated tert-butyl ester (0.0627 mmol, the title compound of Example 3266) in 2 mL of CDCl₃ at room temperature is added 0.5 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting yellow solution is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The crude product is purified to give the title compound of Example 32367.

EXAMPLE 3268 ##STR174## 1,1-Dimethylethyl 3-butyl-5,6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8-acetate

Step 1: Preparation of deconjugated ester

To a solution of ester (0.237 mmol, obtained from Step 2 of Example 3266) in 4 mL of THF at 0° C. is added 310 μL of 1.5M (0.467 mmol) LDA over a 2-min period, and the resulting solution is stirred at 0° C. for 10 min. The mixture is cooled to -78° C., stirred cold for 5 min, and quenched dropwise at -78° C. with 100 μL of acetic acid in 1 mL of hexane. The mixture is stirred cold, then warmed to room temperature and treated with aqueous NaHCO₃. The mixture is extracted with methylene chloride. The combined extracts are washed with water, dried (MgSO₄) and concentrated in vacuo to give a crude mixture. The crude product is purified to give the biphenyl indolizinyl deconjugated ester.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl indolizinyl deconjugated ester (0.165 mmol, obtained from Step 1) in 1 mL of water and 3 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 4 of Example 3257. The crude product is purified to give the title compound of Example 3268.

EXAMPLE 3269 ##STR175## 3-Butyl-5, 6-dihydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8-acetic acid

To a solution of biphenyl indolizinyl tert-butyl ester (0.039 mmol, the title compound of Example in 0.5 mL of chloroform is added 0.25 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is stirred at room temperature until the reaction is complete. The mixture is quenched with methanol and concentrated in vacuo. The residue is purified to give the title compound of Example 3269.

EXAMPLE 3270 ##STR176## 1,1-Dimethylethyl 3-butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-cis-8-acetate

A suspension of the biphenyl indolizinyl unsaturated ester (0.059 mmol, the title compound of Example 3268) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under an atmosphere of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite and concentrated in vacuo. The residue is purified to give the title compound of Example 3270.

EXAMPLE 3271 ##STR177## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-cis-8-acetic acid

To a solution of tert-butyl ester (0.0332 mmol, obtained from Example 3270) in 0.4 mL of CDCl₃ is added 0.2 mL of TFA, and the progress of the reaction is monitored by ¹ H NMR. The resulting solution is allowed to stand at room temperature until the reaction is complete. The reaction mixture is diluted with methanol and concentrated. The residue is purified to give the title compound of Example 3271.

EXAMPLE 3272 ##STR178## 3-Butyl-5,6-dihydro-N-hydroxy-5- 2'-(1H-tetrazol-5-yl) 1.1'-biphenyl!-4-yl!triazolo 4,3-a!pyridin-8(7H)-imine

A mixture of biphenyl keto imidazole (0.094 mmol, the title compound of Example 3260), 20 mg (0.29 mmol) of N-hydroxyamine (hydrochloride salt) and 30 mg of NaOAc in 2 mL of methanol is stirred at 60° C. until the reaction is complete. The mixture is diluted with chloroform and filtered. The solid is washed with methanol. The filtrate is concentrated in vacuo and purified to give the title compound of Example 3272.

EXAMPLE 3273 ##STR179## 3-Butyl-5,6,7,8-tetrahydro-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!-1,2,4-triazolo 4,3-a!pyridin-8-yl!phthalimide

Step 1: Preparation of biphenyl phthalimidyl triazole

To a solution of the biphenyl hydroxy triazole (2.0 mmol, obtained from Step 1 of Example 3261 or 3262), phthalimide (2.0 mmol), and triphenylphosphine (2.0 mmol) in 2.0 mL of THF is added dropwise a solution of diethyl azodicarboxylate (2.0 mmol) in 1 mL of THF at room temperature. The resulting solution is stirred at room temperature until the reaction is complete. The resulting mixture is diluted with ether or ethyl acetate and washed with water. The extracts are dried (MgSO₄) and concentrated in vacuo. The residue is purified to give the the trityl protected phthalimidyl triazole.

Step 2: Detritylation of trityl tetrazole

A solution of trityl-protected biphenyl phthalimidyl triazole (2.0 mmol, obtained from Step 1) in 2 mL of water and 10 mL of acetic acid is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The residue is worked up as described in Step 5 of Example 3257 and purified give the title compound of Example 3273.

EXAMPLE 3274 ##STR180## 3-Butyl-5,6,7,8-tetrahydro-8-amino-5- 2'-(1H-tetrazol-5-yl) 1,1'-biphenyl!-4-yl!triazole

A solution of phthalimidyl triazole (0.6 mmol, the title compound of Example 3273) and 3 μL (1.5 mmol) of hydrazine in 1.0 mL of ethanol is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo, and purified to give the title compound of Example 3274.

Alternatively, the title compound of Example 3274 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, the title compound of Example 3273) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 3274.

Further examples of conformationally restricted angiotensin II antagonists (3275-3739) embraced by Formula V above are located in Tables LXXIII-XCVI.

                  TABLE LXXIII                                                     ______________________________________                                          ##STR181##                                                                    EX. #       R.sup.220   R.sup.221                                              ______________________________________                                         3275.       C.sub.3 H.sub.7 (n)                                                                        H                                                      3276.       C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3277.       C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3278.       C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        3279.       C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   3280.       C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 3281.       C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 3282.       C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            3283.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            3284.       C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             3285.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                                    3286.       C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3287.       C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3288.       C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        3289.       C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   3290.       C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 3291.       C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 3292.       C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            3293.       C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            3294.       C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             ______________________________________                                    

                  TABLE LXXIV                                                      ______________________________________                                          ##STR182##                                                                    EX. #       R.sup.222   R.sup.223                                              ______________________________________                                         3295.       C.sub.3 H.sub.7 (n)                                                                        O                                                      3296.       C.sub.3 H.sub.7 (n)                                                                        S                                                      3297.       C.sub.3 H.sub.7 (n)                                                                        NOH                                                    3298.       C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                           3299.       C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3300.       C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3301.       C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                      3302.       C.sub.4 H.sub.9 (n)                                                                        S                                                      3303.       C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3304.       C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3305.       C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                      ______________________________________                                    

                  TABLE LXXV                                                       ______________________________________                                          ##STR183##                                                                    EX. #       R.sup.224   R.sup.225                                              ______________________________________                                         3306.       C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3307.       C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3308.       C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3309.       C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    ______________________________________                                    

                  TABLE LXXVI                                                      ______________________________________                                          ##STR184##                                                                    EX. #       R.sup.226   R.sup.227                                              ______________________________________                                         3310.       C.sub.3 H.sub.7 (n)                                                                        H                                                      3311.       C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3312.       C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3313.       C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        3314.       C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   3315.       C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 3316.       C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 3317.       C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            3318.       C.sub.3 H.sub.7 (n)                                                                        NH.sub.2                                               3319.       C.sub.3 H.sub.7 (n)                                                                        OH                                                     3320.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            3321.       C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             3322.       C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3323.       C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3324.       C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        3325.       C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   3326.       C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 3327.       C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 3328.       C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            3329.       C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            3330.       C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             ______________________________________                                    

                  TABLE LXXVII                                                     ______________________________________                                          ##STR185##                                                                    EX. #    R.sup.228   R.sup.229                                                                               R.sup.230                                        ______________________________________                                         3331.    CH.sub.3 H.sub.7 (n)                                                                       H        CH.sub.3                                         3332.    C.sub.3 H.sub.7 (n)                                                                        H        C.sub.2 H.sub.5                                  3333.    C.sub.3 H.sub.7 (n)                                                                        H        C.sub.6 H.sub.5                                  3334.    C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 C.sub.6 H.sub.5                         3335.    C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 CO.sub.2 H                              3336.    C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 CH.sub.2 CO.sub.2 H                     3337.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.3                                         3338.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 C.sub.2 H.sub.5                                  3339.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 C.sub.6 H.sub.5                                  3340.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 C.sub.6 H.sub.5                         3341.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 CO.sub.2 H                              3342.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 H                     3343.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.3                                         3344.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                  3345.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.6 H.sub.5                                  3346.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 C.sub.6 H.sub.5                         3347.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CO.sub.2 H                              3348.    C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CH.sub.2 CO.sub.2 H                     3349.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                         3350.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  3351.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                  3352.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                         3353.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              3354.    C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2 CO.sub.2 H                     3355.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                         3356.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.2 H.sub.5                                  3357.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.6 H.sub.5                                  3358.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CO.sub.2 H                              3359.    C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CH.sub.2 CO.sub.2 H                     3360.    C.sub.4 H.sub.9 (n)                                                                        H        C.sub.3                                          3361.    C.sub.4 H.sub.9 (n)                                                                        H        C.sub.2 H.sub.5                                  3362.    C.sub.4 H.sub.9 (n)                                                                        H        C.sub.6 H.sub.5                                  3363.    C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 C.sub.6 H.sub.5                         3364.    C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 CO.sub.2 H                              3365.    C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 CH.sub.2 CO.sub.2 H                     3366.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.3                                         3367.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 C.sub.2 H.sub.5                                  3368.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 C.sub.6 H.sub.5                                  3369.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 C.sub.6 H.sub.5                         3370.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 CO.sub.2 H                              3371.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 H                     3372.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.3                                         3373.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                  3374.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.6 H.sub.5                                  3375.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 C.sub.6 H.sub.5                         3376.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CO.sub.2 H                              3377.    C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CH.sub.2 CO.sub.2 H                     3378.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                         3379.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  3380.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                  3381.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                         3382.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              3383.    C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2 CO.sub.2 H                     3384.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                         3385.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.2 H.sub.5                                  3386.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.6 H.sub.5                                  3387.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CO.sub.2 H                              3388.    C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CH.sub.2 CO.sub.2 H                     ______________________________________                                    

                  TABLE LXXVIII                                                    ______________________________________                                          ##STR186##                                                                    EX. #       R.sup.231   R.sup.232, R.sup.233                                   ______________________________________                                         3389.       C.sub.3 H.sub.7 (n)                                                                        O                                                      3390.       C.sub.3 H.sub.7 (n)                                                                        H, H                                                   3391.       C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.3                                            3392.       C.sub.3 H.sub.7 (n)                                                                        H, C.sub.2 H.sub.5                                     3393.       C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.2 OH                                         3394.       C.sub.3 H.sub.7 (n)                                                                        H, CO.sub.2 H                                          3395.       C.sub.4 H.sub.9 (n)                                                                        H, H                                                   3396.       C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.3                                            3397.       C.sub.4 H.sub.9 (n)                                                                        H, C.sub.2 H.sub.5                                     3398.       C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.2 OH                                         3399.       C.sub.4 H.sub.9 (n)                                                                        H, CO.sub.2 H                                          ______________________________________                                    

                  TABLE LXXVIX                                                     ______________________________________                                          ##STR187##                                                                    EX. #       R.sup.234   R.sup.235, R.sup.236                                   ______________________________________                                         3400.       C.sub.3 H.sub.7 (n)                                                                        O                                                      3401.       C.sub.3 H.sub.7 (n)                                                                        H, H                                                   3402.       C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.3                                            3403.       C.sub.3 H.sub.7 (n)                                                                        H, C.sub.2 H.sub.5                                     3404.       C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.2 OH                                         3405.       C.sub.3 H.sub.7 (n)                                                                        H, CO.sub.2 H                                          3406.       C.sub.4 H.sub.9 (n)                                                                        O                                                      3407.       C.sub.4 H.sub.9 (n)                                                                        H, H                                                   3408.       C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.3                                            3409.       C.sub.4 H.sub.9 (n)                                                                        H, C.sub.2 H.sub.5                                     3410.       C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.2 OH                                         3411.       C.sub.4 H.sub.9 (n)                                                                        H, CO.sub.2 H                                          ______________________________________                                    

                  TABLE LXXX                                                       ______________________________________                                          ##STR188##                                                                    EX. #       R.sup.237   R.sup.238                                              ______________________________________                                         3412.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                               3413.       C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                    3414.       C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           3415.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                      3416.       C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            3417.       C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   3418.       C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                    3419.       C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           3420.       C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                      3421.       C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            3422.       C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   ______________________________________                                    

                  TABLE LXXXI                                                      ______________________________________                                          ##STR189##                                                                    EX. #       R.sup.239   R.sup.240                                              ______________________________________                                         3423.       C.sub.3 H.sub.7 (n)                                                                        H                                                      3424.       C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3425.       C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3426.       C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        3427.       C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   3428.       C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 3429.       C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 3430.       C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            3431.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            3432.       C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             3433.       C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                                    3434.       C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3435.       C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3436.       C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        3437.       C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   3438.       C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 3439.       C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 3440.       C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            3441.       C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            3442.       C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             3443.       C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CO.sub.2 H                                    ______________________________________                                    

                  TABLE LXXXII                                                     ______________________________________                                          ##STR190##                                                                    EX. #       R.sup.241   R.sup.242                                              ______________________________________                                         3444.       C.sub.3 H.sub.7 (n)                                                                        O                                                      3445.       C.sub.3 H.sub.7 (n)                                                                        S                                                      3446.       C.sub.3 H.sub.7 (n)                                                                        NOH                                                    3447.       C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                           3448.       C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3449.       C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3450.       C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                      3451.       C.sub.4 H.sub.9 (n)                                                                        O                                                      3452.       C.sub.4 H.sub.9 (n)                                                                        S                                                      3453.       C.sub.4 H.sub.9 (n)                                                                        NOH                                                    3454.       C.sub.4 H.sub.9 (n)                                                                        CHCO.sub.2 H                                           3455.       C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3456.       C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3457.       C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                      ______________________________________                                    

                  TABLE LXXXIII                                                    ______________________________________                                          ##STR191##                                                                    EX. #       R.sup.243   R.sup.244                                              ______________________________________                                         3458.       C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3459.       C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3460.       C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3461.       C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    ______________________________________                                    

                  TABLE LXXXIV                                                     ______________________________________                                          ##STR192##                                                                    EX. #       R.sup.245   R.sup.246                                              ______________________________________                                         3462        C.sub.3 H.sub.7 (n)                                                                        H                                                      3463        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3464        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3465        C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        3466        C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   3467        C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 3468        C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 3469        C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            3470        C.sub.3 H.sub.7 (n)                                                                        NH.sub.2                                               3471        C.sub.3 H.sub.7 (n)                                                                        OH                                                     3472        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            3473        C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             3474        C.sub.4 H.sub.9 (n)                                                                        H                                                      3475        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3476        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3477        C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        3478        C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   3479        C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 3480        C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 3481        C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            3482        C.sub.4 H.sub.9 (n)                                                                        NH.sub.2                                               3483        C.sub.4 H.sub.9 (n)                                                                        OH                                                     3484        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            3485        C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             ______________________________________                                    

                  TABLE LXXXV                                                      ______________________________________                                          ##STR193##                                                                    EX. #    R.sup.247   R.sup.248                                                                               R.sup.249                                        ______________________________________                                         3486     CH.sub.3 H.sub.7 (n)                                                                       H        CH.sub.3                                         3487     C.sub.3 H.sub.7 (n)                                                                        H        C.sub.2 H.sub.5                                  3488     C.sub.3 H.sub.7 (n)                                                                        H        C.sub.6 H.sub.5                                  3489     C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 C.sub.6 H.sub.5                         3490     C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 CO.sub.2 H                              3491     C.sub.3 H.sub.7 (n)                                                                        H        CH.sub.2 CH.sub.2 CO.sub.2 H                     3492     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.3                                         3493     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 C.sub.2 H.sub.5                                  3494     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 C.sub.6 H.sub.5                                  3495     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 C.sub.6 H.sub.5                         3496     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 CO.sub.2 H                              3497     C.sub.3 H.sub.7 (n)                                                                        CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 H                     3498     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.3                                         3499     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                  3500     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.6 H.sub.5                                  3501     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 C.sub.6 H.sub.5                         3502     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CO.sub.2 H                              3503     C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CH.sub.2 CO.sub.2 H                     3504     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                         3505     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  3506     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                  3507     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                         3508     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              3509     C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2 CO.sub.2 H                     3510     C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                         3511     C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.2 H.sub.5                                  3512     C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.6 H.sub.5                                  3513     C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CO.sub.2 H                              3514     C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CH.sub.2 CO.sub.2 H                     3515     C.sub.4 H.sub.9 (n)                                                                        H        C.sub.3                                          3516     C.sub.4 H.sub.9 (n)                                                                        H        C.sub.2 H.sub.5                                  3517     C.sub.4 H.sub.9 (n)                                                                        H        C.sub.6 H.sub.5                                  3518     C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 C.sub.6 H.sub.5                         3519     C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 CO.sub.2 H                              3520     C.sub.4 H.sub.9 (n)                                                                        H        CH.sub.2 CH.sub.2 CO.sub.2 H                     3521     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.3                                         3522     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 C.sub.2 H.sub.5                                  3523     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 C.sub.6 H.sub.5                                  3524     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 C.sub.6 H.sub.5                         3525     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 CO.sub.2 H                              3526     C.sub.4 H.sub.9 (n)                                                                        CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 H                     3527     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.3                                         3528     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                  3529     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         C.sub.6 H.sub.5                                  3530     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 C.sub.6 H.sub.5                         3531     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CO.sub.2 H                              3532     C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                                                         CH.sub.2 CH.sub.2 CO.sub.2 H                     3533     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.3                                         3534     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.2 H.sub.5                                  3535     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     C.sub.6 H.sub.5                                  3536     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 C.sub.6 H.sub.5                         3537     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CO.sub.2 H                              3538     C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                                                     CH.sub.2 CH.sub.2 CO.sub.2 H                     3539     C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                         3540     C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.2 H.sub.5                                  3541     C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                C.sub.6 H.sub.5                                  3542     C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CO.sub.2 H                              3543     C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.2 CH.sub.2 CO.sub.2 H                     ______________________________________                                    

                  TABLE LXXXVI                                                     ______________________________________                                          ##STR194##                                                                    EX. #       R.sup.250   R.sup.251, R.sup.252                                   ______________________________________                                         3544.       C.sub.3 H.sub.7 (n)                                                                        O                                                      3545        C.sub.3 H.sub.7 (n)                                                                        H, H                                                   3546        C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.3                                            3547        C.sub.3 H.sub.7 (n)                                                                        H, C.sub.2 H.sub.5                                     3548        C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.2 OH                                         3549        C.sub.3 H.sub.7 (n)                                                                        H, CO.sub.2 H                                          3550        C.sub.4 H.sub.9 (n)                                                                        O                                                      3551        C.sub.4 H.sub.9 (n)                                                                        H, H                                                   3552        C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.3                                            3553        C.sub.4 H.sub.9 (n)                                                                        H, C.sub.2 H.sub.5                                     3554        C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.2 OH                                         3555        C.sub.4 H.sub.9 (n)                                                                        H, CO.sub.2 H                                          ______________________________________                                    

                  TABLE LXXXVII                                                    ______________________________________                                          ##STR195##                                                                    EX. #       R.sup.253   R.sup.254, R.sup.255                                   ______________________________________                                         3556        C.sub.3 H.sub.7 (n)                                                                        O                                                      3557        C.sub.3 H.sub.7 (n)                                                                        H, H                                                   3558        C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.3                                            3559        C.sub.3 H.sub.7 (n)                                                                        H, C.sub.2 H.sub.5                                     3560        C.sub.3 H.sub.7 (n)                                                                        H, CH.sub.2 OH                                         3561        C.sub.3 H.sub.7 (n)                                                                        H, CO.sub.2 H                                          3562        C.sub.4 H.sub.9 (n)                                                                        O                                                      3563        C.sub.4 H.sub.9 (n)                                                                        H, H                                                   3564        C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.3                                            3565        C.sub.4 H.sub.9 (n)                                                                        H, C.sub.2 H.sub.5                                     3566        C.sub.4 H.sub.9 (n)                                                                        H, CH.sub.2 OH                                         3567        C.sub.4 H.sub.9 (n)                                                                        H, CO.sub.2 H                                          ______________________________________                                    

                  TABLE LXXXVIII                                                   ______________________________________                                          ##STR196##                                                                    EX. #       R.sup.256   R.sup.257                                              ______________________________________                                         3568        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                               3569        C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                    3570        C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           3571        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                      3572        C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            3573        C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   3574        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2                                               3575        C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                    3576        C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                           3577        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                      3578        C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                            3579        C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                   ______________________________________                                    

                  TABLE LXXXIX                                                     ______________________________________                                          ##STR197##                                                                    EX. #       R.sup.258   R.sup.259                                              ______________________________________                                         3580        C.sub.3 H.sub.7 (n)                                                                        H                                                      3581        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3582        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3583        C.sub.3 H.sub.7 (n)                                                                        (2-ethylphenyl)                                        3584        C.sub.3 H.sub.7 (n)                                                                        (2,6-dimethylphenyl)                                   3585        C.sub.3 H.sub.7 (n)                                                                        phenyl                                                 3586        C.sub.3 H.sub.7 (n)                                                                        benzyl                                                 3587        C.sub.3 H.sub.7 (n)                                                                        phenylethyl                                            3588        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 OH                                            3589        C.sub.3 H.sub.7 (n)                                                                        CO.sub.2 H                                             3590        C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                                    3591        C.sub.4 H.sub.9 (n)                                                                        H                                                      3592        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3593        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3594        C.sub.4 H.sub.9 (n)                                                                        (2-ethylphenyl)                                        3595        C.sub.4 H.sub.9 (n)                                                                        (2,6-dimethylphenyl)                                   3596        C.sub.4 H.sub.9 (n)                                                                        phenyl                                                 3597        C.sub.4 H.sub.9 (n)                                                                        benzyl                                                 3598        C.sub.4 H.sub.9 (n)                                                                        phenylethyl                                            3599        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 OH                                            3600        C.sub.4 H.sub.9 (n)                                                                        CO.sub.2 H                                             3601        C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CO.sub.2 H                                    ______________________________________                                    

                  TABLE XC                                                         ______________________________________                                          ##STR198##                                                                    EX. #       R.sup.260   R.sup.261                                              ______________________________________                                         3602        C.sub.3 H.sub.7 (n)                                                                        O                                                      3603        C.sub.3 H.sub.7 (n)                                                                        S                                                      3604        C.sub.3 H.sub.7 (n)                                                                        NOH                                                    3605        C.sub.3 H.sub.7 (n)                                                                        CHCO.sub.2 H                                           3606        C.sub.3 H.sub.7 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3607        C.sub.3 H.sub.7 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3608        C.sub.3 H.sub.7 (n)                                                                        CHC.sub.2 H.sub.5                                      3609        C.sub.4 H.sub.9 (n)                                                                        O                                                      3610        C.sub.4 H.sub.9 (n)                                                                        S                                                      3611        C.sub.4 H.sub.9 (n)                                                                        NOH                                                    3612        C.sub.4 H.sub.9 (n)                                                                        CHCO.sub.2 H                                           3613        C.sub.4 H.sub.9 (n)                                                                        C(C.sub.2 H.sub.5)CO.sub.2 H                           3614        C.sub.4 H.sub.9 (n)                                                                        C(CH.sub.2 C.sub.6 H.sub.5)CO.sub.2 H                  3615        C.sub.4 H.sub.9 (n)                                                                        CHC.sub.2 H.sub.5                                      ______________________________________                                    

                  TABLE XCI                                                        ______________________________________                                          ##STR199##                                                                    EX. #       R.sup.262   R.sup.263                                              ______________________________________                                         3616        C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                        3617        C.sub.3 H.sub.7 (n)                                                                        C.sub.3 H.sub.7 (n)                                    3618        C.sub.4 H.sub.9 (n)                                                                        C.sub.2 H.sub.5                                        3619        C.sub.4 H.sub.9 (n)                                                                        C.sub.3 H.sub.7 (n)                                    ______________________________________                                    

                  TABLE XCII                                                       ______________________________________                                          ##STR200##                                                                    EX. #       R.sup.264  R.sup.265                                               ______________________________________                                         3620        C.sub.3 H.sub.7 (n)                                                                       H                                                       3621        C.sub.3 H.sub.7 (n)                                                                       C.sub.2 H.sub.5                                         3622        C.sub.3 H.sub.7 (n)                                                                       C.sub.3 H.sub.7 (n)                                     3623        C.sub.3 H.sub.7 (n)                                                                       (2-ethylphenyl)                                         3624        C.sub.3 H.sub.7 (n)                                                                       (2,6-dimethylphenyl)                                    3625        C.sub.3 H.sub.7 (n)                                                                       phenyl                                                  3626        C.sub.3 H.sub.7 (n)                                                                       benzyl                                                  3627        C.sub.3 H.sub.7 (n)                                                                       phenylethyl                                             3628        C.sub.3 H.sub.7 (n)                                                                       NH.sub.2                                                3629        C.sub.3 H.sub.7 (n)                                                                       OH                                                      3630        C.sub.3 H.sub.7 (n)                                                                       CH.sub.2 OH                                             3631        C.sub.3 H.sub.7 (n)                                                                       CO.sub.2 H                                              3632        C.sub.3 H.sub.7 (n)                                                                       OCH.sub.2 C.sub.6 H                                     3633        C.sub.4 H.sub.9 (n)                                                                       H                                                       3634        C.sub.4 H.sub.9 (n)                                                                       C.sub.2 H.sub.5                                         3635        C.sub.4 H.sub.9 (n)                                                                       C.sub.3 H.sub.7 (n)                                     3636        C.sub.4 H.sub.9 (n)                                                                       (2-ethylphenyl)                                         3637        C.sub.4 H.sub.9 (n)                                                                       (2,6-dimethylphenyl)                                    3638        C.sub.4 H.sub.9 (n)                                                                       phenyl                                                  3639        C.sub.4 H.sub.9 (n)                                                                       benzyl                                                  3640        C.sub.4 H.sub.9 (n)                                                                       phenylethyl                                             3641        C.sub.4 H.sub.9 (n)                                                                       NH.sub.2                                                3642        C.sub.4 H.sub.9 (n)                                                                       OH                                                      3643        C.sub.4 H.sub.9 (n)                                                                       CH.sub.2 OH                                             3644        C.sub.4 H.sub.9 (n)                                                                       CO.sub.2 H                                              3645        C.sub.4 H.sub.9 (n)                                                                       OCH.sub.2 C.sub.6 H                                     ______________________________________                                    

                  TABLE XCIII                                                      ______________________________________                                          ##STR201##                                                                    EX. #     R.sup.266 R.sup.267   R.sup.268                                      ______________________________________                                         3646      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.3                                       3647      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.2 H.sub.5                                3648      C.sub.3 H.sub.7 (n)                                                                      H           C.sub.6 H.sub.5                                3649      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       3650      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            3651      C.sub.3 H.sub.7 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   3652      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.3                                       3653      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                3654      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                3655      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       3656      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            3657      C.sub.3 H.sub.7 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   3658      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       3659      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                3660      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                3661      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       3662      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            3663      C.sub.3 H.sub.7 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   3664      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       3665      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                3666      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                3667      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       3668      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            3669      C.sub.3 H.sub.7 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   3670      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       3671      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                3672      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                3673      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            3674      C.sub.3 H.sub.7 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   3675      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.3                                       3676      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.2 H.sub.5                                3677      C.sub.4 H.sub.9 (n)                                                                      H           C.sub.6 H.sub.5                                3678      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 C.sub.6 H.sub.5                       3679      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CO.sub.2 H                            3680      C.sub.4 H.sub.9 (n)                                                                      H           CH.sub.2 CH.sub.2 CO.sub.2 H                   3681      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.3                                       3682      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.2 H.sub.5                                3683      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    C.sub.6 H.sub.5                                3684      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 C.sub.6 H.sub.5                       3685      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CO.sub.2 H                            3686      C.sub.4 H.sub.9 (n)                                                                      CH.sub.3    CH.sub.2 CH.sub.2 CO.sub.2 H                   3687      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.3                                       3688      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                3689      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            C.sub.6 H.sub.5                                3690      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 C.sub.6 H.sub.5                       3691      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CO.sub.2 H                            3692      C.sub.4 H.sub.9 (n)                                                                      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2 CO.sub.2 H                   3693      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.3                                       3694      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.2 H.sub.5                                3695      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        C.sub.6 H.sub.5                                3696      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 C.sub.6 H.sub.5                       3697      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CO.sub.2 H                            3698      C.sub.4 H.sub.9 (n)                                                                      C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2 CO.sub.2 H                   3699      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                       3700      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.2 H.sub.5                                3701      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   C.sub.6 H.sub.5                                3702      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CO.sub.2 H                            3703      C.sub.4 H.sub.9 (n)                                                                      CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.2 CH.sub.2 CO.sub.2 H                   ______________________________________                                    

                  TABLE XCIV                                                       ______________________________________                                          ##STR202##                                                                    EX. #         R.sup.269   R.sup.270,R.sup.271                                  ______________________________________                                         3704          C.sub.3 H.sub.7 (n)                                                                        O                                                    3705          C.sub.3 H.sub.7 (n)                                                                        H,H                                                  3706          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.3                                           3707          C.sub.3 H.sub.7 (n)                                                                        H,C.sub.2 H.sub.5                                    3708          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.2 OH                                        3709          C.sub.3 H.sub.7 (n)                                                                        H,CO.sub.2 H                                         3710          C.sub.4 H.sub.9 (n)                                                                        O                                                    3711          C.sub.4 H.sub.9 (n)                                                                        H,H                                                  3712          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.3                                           3713          C.sub.4 H.sub.9 (n)                                                                        H,C.sub.2 H.sub.5                                    3714          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.2 OH                                        3715          C.sub.4 H.sub.9 (n)                                                                        H,CO.sub.2 H                                         ______________________________________                                    

                  TABLE XCV                                                        ______________________________________                                          ##STR203##                                                                    EX. #         R.sup.272   R.sup.273,R.sup.274                                  ______________________________________                                         3716          C.sub.3 H.sub.7 (n)                                                                        O                                                    3717          C.sub.3 H.sub.7 (n)                                                                        H,H                                                  3718          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.3                                           3719          C.sub.3 H.sub.7 (n)                                                                        H,C.sub.2 H.sub.5                                    3720          C.sub.3 H.sub.7 (n)                                                                        H,CH.sub.2 OH                                        3721          C.sub.3 H.sub.7 (n)                                                                        H,CO.sub.2 H                                         3722          C.sub.4 H.sub.9 (n)                                                                        O                                                    3723          C.sub.4 H.sub.9 (n)                                                                        H,H                                                  3724          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.3                                           3725          C.sub.4 H.sub.9 (n)                                                                        H,C.sub.2 H.sub.5                                    3726          C.sub.4 H.sub.9 (n)                                                                        H,CH.sub.2 OH                                        3727          C.sub.4 H.sub.9 (n)                                                                        H,CO.sub.2 H                                         ______________________________________                                    

                  TABLE XCVI                                                       ______________________________________                                          ##STR204##                                                                    EX. #        R.sup.275   R.sup.276                                             ______________________________________                                         3728         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2                                              3729         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)                                   3730         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          3731         C.sub.3 H.sub.7 (n)                                                                        CH.sub.2 CH.sub.2                                     3732         C.sub.3 H.sub.7 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           3733         C.sub.3 H.sub.7 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  3734         C.sub.4 H.sub.9 (n)                                                                        CH.sub.2                                              3735         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)                                   3736         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)                          3737         C.sub.4 H.sub.9 (n)                                                                        CH.sub.2 CH.sub.2                                     3738         C.sub.4 H.sub.9 (n)                                                                        CH(C.sub.2 H.sub.5)CH.sub.2                           3739         C.sub.4 H.sub.9 (n)                                                                        CH(CH.sub.2 C.sub.6 H.sub.5)CH.sub.2                  ______________________________________                                    

BIOLOGICAL EVALUATION

Assay A: Angiotensin II Binding Activity

Compounds of the invention were tested for ability to bind to the smooth muscle angiotensin II receptor using a rat uterine membrane preparation. Angiotensin II (AII) was purchased from Peninsula Labs. ¹²⁵ I-angiotensin II (specific activity of 2200 Ci/mmol) was purchased from Du Pont-New England Nuclear. Other chemicals were obtained from Sigma Chemical Co. This assay was carried out according to the method of Douglas et al Endocrinology, 106, 120-124 (1980)!. Rat uterine membranes were prepared from fresh tissue. All procedures were carried out at 4° C. Uteri were stripped of fat and homogenized in phosphate-buffered saline at pH 7.4 containing 5 mM EDTA. The homogenate was centrifuged at 1500×g for 20 min., and the supernatant was recentrifuged at 100,000×g for 60 min. The pellet was resuspended in buffer consisting of 2 mM EDTA and 50 mM Tris-HCl (pH 7.5) to a final protein concentration of 4 mg/ml. Assay tubes were charged with 0.25 ml of a solution containing 5 mM MgCl₂, 2 mM EDTA, 0.5% bovine serum albumin, 50 mM Tris-HCl, pH 7.5 and ¹²⁵ I-AII (approximately 10⁵ cpm) in the absence or in the presence of unlabelled ligand. The reaction was initiated by the addition of membrane protein and the mixture was incubated at 25° C. for 60 min. The incubation was terminated with ice-cold 50 mM Tris-HCl (pH 7.5) and the mixture was filtered to separate membrane-bound labeled peptide from the free ligand. The incubation tube and filter were washed with ice-cold buffer. Filters were assayed for radioactivity in a Micromedic gamma counter. Nonspecific binding was defined as binding in the presence of 10 μM of unlabelled AII. Specific binding was calculated as total binding minus nonspecific binding. The receptor binding affinity of an AII antagonist compound was indicated by the concentration (IC₅₀) of the tested AII antagonist which gives 50% displacement of the total specifically bound ¹²⁵ I-AII from the high affinity AII receptor. Binding data were analyzed by a nonlinear least-squares curve fitting program. Results are reported in Table XCVII.

Assay B: In Vitro Vascular Smooth Muscle-Response for AII

The compounds of the invention were tested for antagonist activity in rabbit aortic rings. Male New Zealand white rabbits (2-2.5 kg) were sacrificed using an overdose of pentobarbital and exsanguinated via the carotid arteries. The thoracic aorta was removed, cleaned of adherent fat and connective tissue and then cut into 3-mm ring segments. The endothelium was removed from the rings by gently sliding a rolled-up piece of filter paper into the vessel lumen. The rings were then mounted in a water-jacketed tissue bath, maintained at 37° C., between moveable and fixed ends of a stainless steel wire with the moveable end attached to an FT03 Grass transducer coupled to a Model 7D Grass Polygraph for recording isometric force responses. The bath was filled with 20 ml of oxygenated (95% oxygen/5% carbon dioxide) Krebs solution of the following composition (mM): 130 NaCl, 15 NaHCO₃, 15 KCl, 1.2 NaH₂ PO₄, 1.2 MgSO₄, 2.5 CaCl₂, and 11.4 glucose. The preparations were equilibrated for one hour before approximately one gram of passive tension was placed on the rings. Angiotensin II concentration-response curves were then recorded (3×10⁻¹⁰ to 1×10⁻⁵ M). Each concentration of AII was allowed to elicit its maximal contraction, and then AII was washed out repeatedly for 30 minutes before rechallenging with a higher concentration of AII. Aorta rings were exposed to the test antagonist at 10⁻⁵ M for 5 minutes before challenging with AII. Adjacent segments of the same aorta ring were used for all concentration-response curves in the presence or absence of the test antagonist. The effectiveness of the test compound was expressed in terms of pA₂ values and were calculated according to H. O. Schild Br. J. Pharmacol. Chemother., 2, 189-206 (1947)!. The pA₂ value is the concentration of the antagonist which increases the IC₅₀ value for AII by a factor of two. Each test antagonist was evaluated in aorta rings from two rabbits. Results are reported in Table XCVII.

                  TABLE XCVII                                                      ______________________________________                                         In Vitro Angiotensin II                                                        Activity of Compounds of the Invention                                         Test Compound                                                                               .sup.1 Assay A .sup.2 Assay B                                     Example #    IC.sub.50 (nM) pA.sub.2                                           ______________________________________                                          1           190            6.40/6.27                                           2           2100           5.84/6.58                                           3           270            7.27/6.65                                           4           51             7.65/7.84                                           5           60             7.86/8.15                                           6           2800           NA                                                  7           15000          NA                                                  8           27             NA                                                  9           44             7.15/7.24                                           10          330            NA                                                  11          120            NA                                                  12          110            6.66/7.05                                           13          23             7.00/6.86                                           14          120            6.48/6.26                                           15          160            6.46/6.73                                           16          440            8.11/7.79                                           17          41             7.79/7.27                                           18          200            NA                                                  19          67             7.15/6.85                                           20          240            6.89/6.85                                           21          66             6.98/6.13                                           24          36             NA                                                 351 (cis)    15             8.63/8.43                                          351 (trans)  110            7.11/7.06                                          363 (cis)    11             8.77/-                                             363 (trans)  41             7.19/7.73                                          ______________________________________                                          .sup.1 Assay A: Angiotensin II Binding Activity                                .sup.2 Assay B: In Vitro Vascular Smooth Muscle Response                       NA = Not Assayed                                                         

Also embraced within this invention is a class of pharmaceutical compositions comprising one or more compounds of Formula I in association with one or more non-toxic, pharmaceutically acceptable carriers and/or diluents and/or adjuvants (collectively referred to herein as "carrier" materials) and, if desired, other active ingredients. The compounds of the present invention may be administered by any suitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a dose effective for the treatment intended. The compounds and composition may, for example, be administered intravascularly, intraperitoneally, subcutaneously, intramuscularly or topically.

For oral administration, the pharmaceutical composition may be in the form of, for example, a tablet, capsule, suspension or liquid. The pharmaceutical composition is preferably made in the form of a dosage unit containing a particular amount of the active ingredient. Examples of such dosage units are tablets or capsules. These may with advantage contain an amount of active ingredient from about 1 to 250 mg, preferably from about 25 to 150 MG. A suitable daily dose for a mammal may vary widely depending on the condition of the patient and other factors. However, a dose of from about 0.1 to 3000 mg/kg body weight, particularly from about 1 to 100 mg/kg body weight, may be appropriate.

The active ingredient may also be administered by injection as a composition wherein, for example, saline, dextrose or water may be used as a suitable carrier. A suitable daily dose is from about 0.1 to 100 mg/kg body weight injected per day in multiple doses depending on the disease being treated. A preferred daily dose would be from about 1 to 30 mg/kg body weight. Compounds indicated for prophylactic therapy will preferably be administered in a daily dose generally in a range from about 0.1 mg to about 100 mg per kilogram of body weight per day. A more preferred dosage will be a range from about 1 mg to about 100 mg per kilogram of body weight. Most preferred is a dosage in a range from about 1 to about 50 mg per kilogram of body weight per day. A suitable dose can be administered, in multiple sub-doses per day. These sub-doses may be administered in unit dosage forms. Typically, a dose or sub-dose may contain from about 1 mg to about 100 mg of active compound per unit dosage form. A more preferred dosage will contain from about 2 mg to about 50 mg of active compound per unit dosage form. Most preferred is a dosage form containing from about 3 mg to about 25 mg of active compound per unit dose.

The dosage regimen for treating a disease condition with the compounds and/or compositions of this invention is selected in accordance with a variety of factors, including the type, age, weight, sex and medical condition of the patient, the severity of the disease, the route of administration, and the particular compound employed, and thus may vary widely.

For therapeutic purposes, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate to the indicated route of administration. If administered per os, the compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, cellulose alkyl esters, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, gelatin, acacia gum, sodium alginate, polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted or encapsulated for convenient administration. Such capsules or tablets may contain a controlled-release formulation as may be provided in a dispersion of active compound in hydroxypropylmethyl cellulose. Formulations for parenteral administration may be in the form of aqueous or non-aqueous isotonic sterile injection solutions or suspensions. These solutions and suspensions may be prepared from sterile powders or granules having one or more of the carriers or diluents mentioned for use in the formulations for oral administration. The compounds may be dissolved in water, polyethylene glycol, propylene glycol, ethanol, corn oil, cottonseed oil, peanut oil, sesame oil, benzyl alcohol, sodium chloride, and/or various buffers. Other adjuvants and modes of administration are well and widely known in the pharmaceutical art.

Although this invention has been described with respect to specific embodiments, the details of these embodiments are not to be construed as limitations. 

What is claimed is:
 1. An angiotensin II antagonist wherein a tetrazole-substituted biphenyl methylene radical is attached in a conformationally restricted manner to a monocyclic heterocyclic ring wherein said methylene is incorporated in a ring fused to said heterocyclic ring.
 2. A pharmaceutical composition comprising a therapeutically-effective amount of an angiotensin II antagonist compound and a pharmaceutically-acceptable carrier or diluent, said antagonist compound selected from a family of compounds of Formula III ##STR205## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene; wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, alkylcarboxyalkyl, hydroxyl, amino, phthalimidyl, aralkoxy, ##STR206## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl and aralkyl; wherein R⁷ is hydrido or halo; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹² and R¹³ taken together is ═O;or a pharmaceutically suitable salt thereof.
 3. The pharmaceutical composition of claim 2 wherein R⁴ is alkyl when R⁵ is hydroxyl, and wherein R⁸ and R⁹ are not both aralkyl; and wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; or a pharmaceutically suitable salt thereof.
 4. The pharmaceutical composition of claim 3 wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, CHC₂ H₅ and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, benzyl, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, amino, phenethyl, phenyl, ##STR207## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, chloro, fluoro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 5. A pharmaceutical composition comprising a therapeutically-effective amount of an angiotensin II antagonist compound and a pharmaceutically-acceptable carrier or diluent, said antagonist compound selected from a family of compounds of Formula IV ##STR208## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene; wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, phthalimidyl, alkylcarboxyalkyl, aryl, aralkyl, hydroxyl, amino, aralkoxy, ##STR209## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl and aralkyl; wherein R⁷ is hydrido or halo; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹² and R¹³ taken together is ═O;or a pharmaceutically suitable salt thereof.
 6. The pharmaceutical composition of claim 5 wherein R⁴ is alkyl when R⁵ is hydroxyl and wherein R⁸ and R⁹ are not both aralkyl; wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; and wherein R³ is selected from C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, CHCO₂ H and CHC₂ H₅ ; or a pharmaceutically suitable salt thereof.
 7. The pharmaceutical composition of claim 6 wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl, phenethyl, benzyl, ##STR210## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, chloro, iodo and fluoro; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 8. A pharmaceutical composition comprising a therapeutically-effective amount of an angiotensin II antagonist compound and a pharmaceutically-acceptable carrier or diluent, said antagonist compound selected from a family of compounds of Formula V ##STR211## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ --or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R² is selected from hydrido, halo, alkyl and aryl; wherein R³ is selected from oxygen, sulfur, alkylidene, alkylcarboxyalkylidene, carboxyalkylidene and hydroxyamino; wherein R⁴ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, hydroxyl, amino, phthalimidyl, aralkoxy, ##STR212## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, aryl, and aralkyl; wherein R⁷ is halo or hydrido; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹⁰ and R¹¹ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 9. The pharmaceutical composition of claim 8 wherein R⁴ is aryl or aralkyl only when R² is hydrido or halo; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ C(CH₃) and CHCO₂ H; wherein R⁴ is alkyl where R⁵ is hydroxyl; wherein R⁸ is aralkyl where R² is hydrido or halo; wherein R⁸ and R⁹ are not both aralkyl; wherein R¹¹ is alkyl when R² is aryl or halo; and wherein R¹³ is alkyl when R² is aryl or halo; or a pharmaceutically suitable salt thereof.
 10. The pharmaceutical composition of claim 9 wherein R⁶ is selected from hydrido, ethyl, hydroxymethyl, --CH₂ CO₂ H and --(CH₂)₃ CO₂ H; or is aryl or aralkyl provided R² is hydrido; or a pharmaceutically suitable salt thereof.
 11. The pharmaceutical composition of claim 10 wherein R¹ is n-propyl or n-butyl; wherein R² is selected from hydrido, chloro, methyl, ethyl, n-propyl, n-butyl, 2-ethylphenyl and 2,6-dimethylphenyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl phenethyl, benzyl, ##STR213## provided R⁴ is selected from phenyl, benzyl and phenethyl only when R² is hydrido or chloro; wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --(C₂ H₅)CH₂ CO₂ H, --(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, chloro, bromo, fluoro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 12. A therapeutic method for treating a circulatory disorder, said method comprising administering to a subject having such disorder a therapeutically-effective amount of a compound of Formula III ##STR214## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene; wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, alkylcarboxyalkyl, hydroxyl, amino, phthalimidyl, aralkoxy, ##STR215## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl and aralkyl; wherein R⁷ is hydrido or halo; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹² and R¹³ taken together is ═O;or a pharmaceutically suitable salt thereof.
 13. The method of claim 12 wherein R⁴ is alkyl when R⁵ is hydroxyl, and wherein R⁸ and R⁹ are not both aralkyl; and wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; or a pharmaceutically suitable salt thereof.
 14. The method of claim 13 wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHC₂ H₅, CHCO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, benzyl, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, amino, phenethyl, phenyl, ##STR216## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; where R⁷ is selected from hydrido, bromo, chloro, fluoro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 15. A therapeutic method for treating a circulatory disorder, said method comprising administering to a subject having such disorder a therapeutically-effective amount of a compound of Formula IV ##STR217## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, alkylidene, alkylcarboxyalkylidene and carboxyalkylidene; wherein R⁴ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, carboxyaralkyl, phthalimidyl, alkylcarboxyalkyl, aryl, aralkyl, hydroxyl, amino, aralkoxy, ##STR218## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, carboxyl, hydroxyalkyl, carboxyalkyl, alkylcarboxyalkyl, aryl, and aralkyl; wherein R⁷ is hydrido or halo; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹² and R¹³ taken together is ═O;or a pharmaceutically suitable salt thereof.
 16. The method of claim 15 wherein R⁴ is alkyl when R⁵ is hydroxyl and wherein R⁸ and R⁹ are not both aralkyl; wherein R⁶ is selected from hydrido, alkyl of C₁ to C₆, aryl, aralkyl, hydroxyalkyl and carboxyalkyl; and wherein R³ is selected from C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CH₂ CO₂ H, C(CH₂ C₆ H₅)CH₂ CO₂ H, CHCO₂ H and CHC₂ H₅ ; or a pharmaceutically suitable salt thereof.
 17. The method of claim 16 wherein R¹ is n-propyl or n-butyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H, C(CH₂ C₆ H₅)CO₂ H, C(C₂ H₅)CO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl, phenethyl, benzyl, ##STR219## wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, bromo, chloro, iodo and fluoro; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 18. A therapeutic method for treating a circulatory disorder, said method comprising administering to a subject having such disorder a therapeutically-effective amount of a compound of Formula V ##STR220## wherein Y is (CH₂)_(n) and n is 1 to 3; wherein Z is C═R³ or CR⁴ R⁵, orwherein Y and Z together forms --CR⁷ ═CR⁶ --, --CH₂ --CR⁷ ═CR⁶ -- or --CH₂ --CH₂ --CR⁷ ═CR⁶ --; wherein R¹ is alkyl; wherein R² is selected from hydrido, halo, alkyl and aryl; wherein R³ is selected from oxygen, sulfur, alkylidene, alkylcarboxyalkylidene, carboxyalkylidene and hydroxyamino; wherein R⁴ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, carboxyaralkyl, aryl, aralkyl, hydroxyl, amino, phthalimidyl, aralkoxy, ##STR221## wherein R⁵ is hydrido or hydroxyl; wherein R⁶ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl, alkylcarboxyalkyl, carboxyalkyl, aryl, and aralkyl; wherein R⁷ is halo or hydrido; wherein R⁸ is selected from hydrido, alkyl and aralkyl; wherein R⁹ is selected from alkyl, aryl, aralkyl, hydrazidylcarboalkyl, carboxyl and carboxyalkyl; wherein R¹⁰ is hydrido or alkyl; wherein R¹¹ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹⁰ and R¹¹ taken together is ═O; wherein R¹² is hydrido or alkyl; and wherein R¹³ is selected from hydrido, alkyl, hydroxyalkyl, carboxyl and carboxyalkyl, or wherein R¹³ and R¹² taken together is ═O;or a pharmaceutically suitable salt thereof.
 19. The method of claim 18 wherein R⁴ is aryl or aralkyl only when R² is hydrido or halo; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ C(CH₃) and CHCO₂ H; wherein R⁴ is alkyl where R⁵ is hydroxyl; wherein R⁸ is aralkyl where R² is hydrido or halo; wherein R⁸ and R⁹ are not both aralkyl; wherein R¹¹ is alkyl when R² is aryl or halo; and wherein R¹³ is alkyl when R² is aryl or halo; or a pharmaceutically suitable salt thereof.
 20. The method of claim 19 wherein R⁶ is selected from hydrido, ethyl, hydroxymethyl, --CH₂ CO₂ H and --(CH₂)₃ CO₂ H; or is aryl or aralkyl provided R² is hydrido; or a pharmaceutically suitable salt thereof.
 21. The method of claim 20 wherein R¹ is n-propyl or n-butyl; wherein R² is selected from hydrido, chloro, methyl, ethyl, n-propyl, n-butyl, 2-ethylphenyl and 2,6-dimethylphenyl; wherein R³ is selected from oxygen, sulfur, hydroxyamino, CHCO₂ H and CHCO₂ C(CH₃)₃ ; wherein R⁴ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, t-butoxycarbonylmethyl, hydroxyl, amino, t-butoxycarbonylpropyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenylmethoxy, 2-ethylphenyl, 2,6-dimethylphenyl, phenyl phenethyl, benzyl, ##STR222## provided R⁴ is selected from phenyl, benzyl and phenethyl only when R² is hydrido or chloro; wherein R⁵ is hydrido or hydroxyl, provided that when R⁵ is hydroxyl, R⁴ is ethyl or n-propyl; wherein R⁶ is selected from hydrido, ethyl, n-propyl, hydroxymethyl, --(CH₂)₃ CO₂ H, --CH₂ CO₂ H, --(CH₂)₂ CO₂ H, t-butoxycarbonylmethyl, t-butoxycarbonylpropyl, --CH(CH₂ C₆ H₅)CO₂ H, --CH(C₂ H₅)CH₂ CO₂ H, --CH(CH₂ C₆ H₅)CH₂ CO₂ H, phenyl, 2-ethylphenyl, 2,6-dimethylphenyl, phenethyl and benzyl; wherein R⁷ is selected from hydrido, chloro, bromo, fluoro and iodo; wherein R⁸ is selected from hydrido, methyl, ethyl, propyl and benzyl, provided that R⁸ is benzyl where R², if present, is hydrido or chloro; wherein R⁹ is selected from methyl, ethyl, phenyl, benzyl, --(CH₂)₂ CONHNH₂, --CH₂ CO₂ H and --(CH₂)₂ CO₂ H, provided that R⁹ and R⁸ are not both benzyl; wherein R¹⁰ is hydrido or methyl; wherein R¹¹ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹¹ and R¹⁰ taken together is ═O; wherein R¹² is hydrido or methyl; and wherein R¹³ is selected from hydrido, methyl, ethyl, hydroxymethyl and carboxyl, or wherein R¹³ and R¹² taken together is ═O; or a pharmaceutically suitable salt thereof.
 22. The method of claim 12, 15 or 18 wherein said circulatory disorder is a cardiovascular disease.
 23. The method of claim 12, 15 or 18 wherein said circulatory disorder is hypertension.
 24. The method of claim 12, 15 or 18 wherein said circulatory disorder is congestive heart failure. 